European Journal of Chemistry 2012, 3(2), 214-219 | doi: https://doi.org/10.5155/eurjchem.3.2.214-219.588 | Get rights and content






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Novel indole-2-carboxylic acid analogues: Synthesis and a new light in to their antioxidant potentials


Nagaraja Naik (1,*) , Vishwanath Sharath (2) , Honnaiah Vijay Kumar (3)

(1) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570006, Karnataka, India
(2) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570006, Karnataka, India
(3) Department of Organic Chemistry, Indian Institute of Science, Bangalore, 560012, India
(*) Corresponding Author

Received: 14 Jan 2012 | Revised: 20 Feb 2012 | Accepted: 21 Feb 2012 | Published: 30 Jun 2012 | Issue Date: June 2012

Abstract


Two series of novel indole-2-carboxylic acid derivatives is reported. In the first series, N-substituted derivatives (3a-h) were synthesized via acylation of indole-2-carboxylic acid followed by aldol condensation reaction. Whereas, in the second series, indole-2-carboxamides (5a-g) were synthesized through conversion of acid to its acid chloride followed by coupling of substituted anilines. Structures of the newly synthesized compounds were confirmed by elemental analysis and spectral IR, 1H NMR and mass data and were screened for antioxidant activity. Among the first series, compound 3g showed higher antioxidant activity and whereas, in the second series compounds 5b and 5c exhibited potential antioxidant activity. Compounds 3g, 5b and 5c exhibited for its enhanced antioxidant activity.

3_2_214_219_800


Keywords


DPPH; Antioxidant activity; Substituted anilines; Indole-2-carboxylic acid; Indole-2-carboxamide; Butylated hydroxy anisole

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DOI: 10.5155/eurjchem.3.2.214-219.588

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Funding information


Indian Institute of Science, Bangalore, India

Citations

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How to cite


Naik, N.; Sharath, V.; Kumar, H. Eur. J. Chem. 2012, 3(2), 214-219. doi:10.5155/eurjchem.3.2.214-219.588
Naik, N.; Sharath, V.; Kumar, H. Novel indole-2-carboxylic acid analogues: Synthesis and a new light in to their antioxidant potentials. Eur. J. Chem. 2012, 3(2), 214-219. doi:10.5155/eurjchem.3.2.214-219.588
Naik, N., Sharath, V., & Kumar, H. (2012). Novel indole-2-carboxylic acid analogues: Synthesis and a new light in to their antioxidant potentials. European Journal of Chemistry, 3(2), 214-219. doi:10.5155/eurjchem.3.2.214-219.588
Naik, Nagaraja, Vishwanath Sharath, & Honnaiah Vijay Kumar. "Novel indole-2-carboxylic acid analogues: Synthesis and a new light in to their antioxidant potentials." European Journal of Chemistry [Online], 3.2 (2012): 214-219. Web. 28 Feb. 2020
Naik, Nagaraja, Sharath, Vishwanath, AND Kumar, Honnaiah. "Novel indole-2-carboxylic acid analogues: Synthesis and a new light in to their antioxidant potentials" European Journal of Chemistry [Online], Volume 3 Number 2 (30 June 2012)

DOI Link: https://doi.org/10.5155/eurjchem.3.2.214-219.588

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