European Journal of Chemistry

Novel indole-2-carboxylic acid analogues: Synthesis and a new light in to their antioxidant potentials

Main Article Content

Nagaraja Naik
Vishwanath Sharath
Honnaiah Vijay Kumar


Two series of novel indole-2-carboxylic acid derivatives is reported. In the first series, N-substituted derivatives (3a-h) were synthesized via acylation of indole-2-carboxylic acid followed by aldol condensation reaction. Whereas, in the second series, indole-2-carboxamides (5a-g) were synthesized through conversion of acid to its acid chloride followed by coupling of substituted anilines. Structures of the newly synthesized compounds were confirmed by elemental analysis and spectral IR, 1H NMR and mass data and were screened for antioxidant activity. Among the first series, compound 3g showed higher antioxidant activity and whereas, in the second series compounds 5b and 5c exhibited potential antioxidant activity. Compounds 3g, 5b and 5c exhibited for its enhanced antioxidant activity.


icon graph This Abstract was viewed 2716 times | icon graph Article PDF downloaded 1624 times

How to Cite
Naik, N.; Sharath, V.; Kumar, H. V. Novel Indole-2-Carboxylic Acid Analogues: Synthesis and a New Light in to Their Antioxidant Potentials. Eur. J. Chem. 2012, 3, 214-219.

Article Details

Crossref - Scopus - Google - European PMC

[1]. Yen, G. C.; Chen, H. Y. J. Agric. Food. Chem. 1995, 43, 27-32.

[2]. Halliwell, B.; Gutteridge, J. M. C. Free Radicals in Biology and Medicine, 3rd edition, Oxford, London, 1999, 246-350.

[3]. Block, G. Nutr. Rev. 1992, 50, 207-213.

[4]. Rice-Evans, A. C.; Miller, N. J.; Paganga, G. Free Radical Biol. Med. 1996, 20, 933-956.

[5]. Sudha, K.; Rao, A.; Rao, S.; Rao, A. Neurol. India 2003, 51, 60-62.

[6]. Halliwell, B. Drugs Aging 2001, 18, 685-716.

[7]. Sundberg, R. J. Indoles, Academic Press, San Diego, 1996.

[8]. Faulkner, D. J. Nat. Prod. Rep. 2001, 18, 1-49.

[9]. Ninomiya, I. J. Nat. Prod. 1992, 55, 541-564.

[10]. Denhart, D. J.; Deskus, J. A.; Ditta, J. L.; Gao, Q.; King, H. D.; Kozlowski, E. S.; Meng, Z.; Lapaglia, M. A.; Mattson, G. K.; Molski, T. F.; Taber, M. T.; Lodge, N. J.; Mattson, R. J.; Macor, J. E. Bioorg. Med. Chem. Lett. 2009, 4031-4033.

[11]. Bandini, M.; Melloni, A.; Umani-Ronchi. Angew. Chem., Int. Ed. 2004, 43, 550-556.

[12]. Austin, J. F.; MacMillan, D. W. C. J. Am. Chem. Soc. 2002, 124, 1172-1173.

[13]. Jensen, K. B.; Thorhange, J.; Hazel, R. G.; Jorgenson, K. A. Angew. Chem., Int. Ed. 2001, 40, 160-163.<160::AID-ANIE160>3.0.CO;2-S

[14]. Srivastava, N.; Banik, B. K. J. Org. Chem. 2003, 68, 2109-2114.

[15]. Bartoli, G.; Bartolacci, M.; Bosco, M.; Foglia, G.; Giuliani, A.; Marcantoni, E.; Sambri, L.; Torregiani, E. J. Org. Chem. 2003, 68, 4594-4597.

[16]. Yoshiaki, N.; Masato, Y.; Youichi, I.; Masnobu, H.; Sakae, U. J. Am. Chem. Soc. 2002, 124, 11846-11847.

[17]. Wenkert, E.; Angell, E. C.; Ferreira, V. F.; Michelotti, E. L.; Piettre, S. R.; Sheu, J. H.; Swindell, C. S. J. Org. Chem. 1986, 51, 2343-2351.

[18]. Vijay, K. H.; Kishor, K. C.; Naik, N. Med. Chem. Res. 2011, 20, 101-108.

[19]. Vijay, K. H.; Nagaraja, N. Eur. J. Med. Chem. 2010, 45(1), 2-10.

[20]. Nagaraja, N.; Vijay, K. H.; Harini, S. T. Eur. J. Chem. 2011, 2(3), 337-341.

[21]. Blois, M. S. Nature 1958, 26, 1199-1200.

[22]. Re, R.; Pellergini, N.; Proteggenete, A.; Pannala, A.; Yang, M.; Rice Evans, C. Free Radic. Biol. Med. 1999, 26, 1231-1237.

[23]. Oyaizu, M. Jpn. J. Nut. 1986, 44, 307-315.

[24]. Apak, R.; Guclu, K.; Ozyurek, M.; Celik, S. E. Microchim Acta. 2008, 160, 413-419.

Supporting Agencies

Indian Institute of Science, Bangalore, India
Most read articles by the same author(s)

Dimensions - Altmetric - scite_ - PlumX

Downloads and views


Download data is not yet available.


Metrics Loading ...
License Terms

License Terms


Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License ( By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License ( are administered by Atlanta Publishing House LLC (European Journal of Chemistry).