European Journal of Chemistry 2010, 1(1), 44-46. doi:10.5155/eurjchem.1.1.44-46.13

Effect of calcitonin on lipid peroxidation in ovariectomized rats


Mehmet Berkoz (1) , Serap Yalin (2,*) , Ulku Comelekoglu (3) , Selda Bagis (4)

(1) Mersin University
(2) Mersin University Pharmacy Faculty, Department of Biochemistry, Mersin
(3) Mersin University, Medical Faculty
(4) Baskent University, Medical Faculty, Adana
(*) Corresponding Author

Received: 24 Mar 2010, Accepted: 24 Mar 2010, Published: 31 Mar 2010

Abstract


Calcitonin is one of the active substances which is recently used effectively in osteoporosis treatment. In literature there is no information whether calcitonin cause oxidative stress or not. In this study, subcutaneous calcitonin is applied to rats having experimental postmenopausal osteoporosis and the effects of calcitonin on lipid peroxidation and antioxidant system were investigated. Forty-five healthy adult female Swiss albino Wistar rats were used in this study. The rats were divided into three equal groups as control, ovariectomized (Ovx) and ovariectomized+calcitonin (Ovx-CAL). The rats in Ovx and Ovx-CAL were anaesthetized and underwent a bilateral ovariectomy via ventral incision. Ten weeks after ovariectomy, salmon calcitonin (2 IU/kg body weight) was administered via s.c. at a volume of 1 mL per week for 12 weeks to the Ovx-CAL group. At the end of the drug treatment, livers and kidneys of rats were removed and malondialdehyde (MDA) levels and catalase (CAT) activities were determined by biochemical analysis methods. Data were analyzed by one-way ANOVA followed by the post-hoc LSD multiple test. The liver and kidney MDA levels were increased whereas the activity of CAT enzyme was decreased as a result of ovariectomy compared to values in the control group. Similar results were observed in Ovx-CAL group; however, the decline in the CAT activity in the kidney was not significant. In conclusion, we may suggest that calcitonin treatment increases the oxidative stress in osteoporotic rats.

1_1_44_46_800


Keywords


Osteoporosis; oxidative stress; antioxidant; ovariectomy; calcitonin

Full Text:

PDF /    /


DOI: 10.5155/eurjchem.1.1.44-46.13

Article Metrics


This Abstract was viewed 529 times | PDF Article downloaded 191 times

Citations

/


[1]. Wale Johnson Adeyemi, Luqman Aribidesi Olayaki
Synergistic and non-synergistic effects of salmon calcitonin and omega - 3 fatty acids on antioxidant, anti-inflammatory, and haematological indices in diabetic rats
Biomedicine & Pharmacotherapy  99, 867, 2018
DOI: 10.1016/j.biopha.2018.01.085
/


[2]. Wale Johnson Adeyemi, Luqman Aribidesi Olayaki
Calcitonin and Omega–3 Fatty Acids Exhibit Antagonistic and Non-Additive Effects in Experimental Diabetes
Pathophysiology  25(2), 117, 2018
DOI: 10.1016/j.pathophys.2018.02.003
/


[3]. Wale Johnson Adeyemi, Luqman Aribidesi Olayaki
Effects of salmon calcitonin and omega – 3 fatty acids on selected biomarkers in experimental diabetic – osteoarthritic rats
Synergy  8, 100045, 2019
DOI: 10.1016/j.synres.2018.100045
/


References

[1]. Song, Y.; Liebschner, M. A.; Gunaratne, G. H. Biophys. J. 2004, 87, 3642-3647.
doi:10.1529/biophysj.104.044511
PMid:15377523    PMCid:1304878

[2]. Grynpas, M. D.; Huckell, B.; Pritzker, K. P.; Hancock, R. G.; Kessler, M. J. P. R. Health Sci. J. 1989, 8, 197-204.

[3]. Recker, R. R. Proc. Soc. Exp. Biol. Med. 1989, 191, 272-274.
PMid:2740358

[4]. Khosla, S. J. Clin. Endocrinol. Metab. 2010, 95, 3-10.
doi:10.1210/jc.2009-1740

[5]. Davidson, M. R. J. Midwifery Wom. Heal. 2003, 48, 39-52.
doi:10.1016/S1526-9523(02)00359-8
PMid:17571623

[6]. Theodorou, D. J.; Theodorou, S. J.; Sartoris, D. J. Compr. Ther. 2002, 28, 109-122.
doi:10.1007/s12019-002-0048-2
PMid:12085458

[7]. Pazzaglia, U. E.; Zatti, G.; Di Nucci, A.; Coci, A. Calcif. Tissue Int. 1993, 52, 125-129.
doi:10.1007/BF00308321
PMid:8443688

[8]. Plosker, G. L.; McTavish, D. Drugs Aging. 1996, 8, 378-400.
doi:10.2165/00002512-199608050-00006

[9]. Mehta, N. M.; Malootian, A.; Gilligan, J. P. Curr. Pharm. Des. 2003, 9, 2659-2676.
doi:10.2174/1381612033453622
PMid:14529539

[10]. El-Hajj Fuleihan, G. J. Med. Liban. 1998, 46, 23-28.
PMid:9795519

[11]. Rizer, M. K. Prim. Care. 2006, 33, 943-951.
doi:10.1016/j.pop.2006.09.004
PMid:17169675

[12]. Hawker, G. A. J. Rheumatol. Suppl. 1996, 45, 2-5.

[13]. Kulak, C. A.; Bilezikian, J. P. Int. J. Fertil. Womens Med. 1998, 43, 56-64.
PMid:9609204

[14]. Rao, L. G. Endocrinology Rounds. 2005, 5, 7-12.

[15]. Rao, L. G.; Guns, E.; Rao, A. V. Agro. Food Ind. Hi Tec. 2003, 14, 25-30,

[16]. Yalin, S.; Bagis, S.; Polat, G.; Dogruer, N.; Cenk, Aksit, S.; Hatungil, R.; Erdogan, C. Clin. Exp. Rheumatol. 2005, 23, 689-692.
PMid:16173248

[17]. Yagi, K. Methods Mol. Biol. 1998, 108, 101-106.
PMid:9921519

[18]. Aebi, H. Methods Enzymol. 1984, 105, 121-126.
doi:10.1016/S0076-6879(84)05016-3

[19]. Lowry, O. H.; Rosebrough, N. J.; Farr, A. L.; Randall, R. J. J. Biol. Chem. 1951, 193, 265-275.

[20]. Yalin, S.; Comelekoglu, U.; Bagis, S.; Sahin, N. O.; Ogenler, O.; Hatungil, R. Ecotoxicol. Environ. Saf. 2006, 65, 140-144.
doi:10.1016/j.ecoenv.2005.06.006
PMid:16095692

[21]. Kume-Kick, J.; Ferris, D. C.; Russo-Menna, I.; Rice, M. E. Brain Res. 1996, 738, 8-14.
doi:10.1016/0006-8993(96)00744-5

[22]. Borrás, C.; Sastre, J.; García-Sala, D.; Lloret, A.; Pallardó, F. V.; Viña, J. Free Radic. Biol. Med. 2003, 34, 546-552.
doi:10.1016/S0891-5849(02)01356-4

[23]. Muthusami, S.; Ramachandran, I.; Muthusami, B.; Vasudevan, G.; Prabhu, V.; Subramaniam, V.; Jagadeesan, A.; Narasimhan, S. Clin. Chim. Acta. 2005, 360, 81-86.
doi:10.1016/j.cccn.2005.04.014
PMid:15970279

[24]. Sreelathakumari, K. T., Menon, V. P.; Leelamma, S. Indian J. Med. Res. 1993, 98, 305-308.
PMid:8132235

[25]. Dombrecht, E. J.; Cos, P.; Vanden, Berghe, D.; Van Offel, J. F.; Schuerwegh, A. J.; Bridts, C. H.; Stevens, W. J.; De Clerck, L.S. Biochem. Biophys. Res. Commun. 2004, 314, 675-680.
doi:10.1016/j.bbrc.2003.12.149
PMid:14741688

[26]. Dombrecht, E. J.; De Tollenaere, C. B.; Aerts, K.; Cos, P.; Schuerwegh, A. J.; Bridts, C. H.; Van Offel, J. F.; Ebo, D. G.; Stevens, W. J.; De Clerck, L. S. Biochem. Biophys. Res. Commun. 2006, 348, 459-464.
doi:10.1016/j.bbrc.2006.07.075
PMid:16884693

[27]. Ozgocmen, S.; Kaya, H.; Fadillioglu, E.; Yilmaz, Z. Arch. Med. Res. 2007, 38, 196-205.
doi:10.1016/j.arcmed.2006.09.010
PMid:17227729

[28]. Ozgonul, M.; Oge, A.; Sezer, E. D.; Bayraktar, F.; Sozmen, E. Y. Endocr. Res. 2003, 29, 183-189.
doi:10.1081/ERC-120022299

[29]. Karsdal, M. A.; Henriksen, K.; Arnold, M.; Christiansen, C. BioDrugs. 2008, 22, 137-144.
doi:10.2165/00063030-200822030-00001
PMid:18481897

[30]. Chesnut, C. H.; Azria, M.; Silverman, S.; Engelhardt, M.; Olson, M.; Mindeholm, L. Osteoporos. Int. 2008, 19, 479-491.
doi:10.1007/s00198-007-0490-1
PMid:18071651


How to cite


Berkoz, M.; Yalin, S.; Comelekoglu, U.; Bagis, S. Eur. J. Chem. 2010, 1(1), 44-46. doi:10.5155/eurjchem.1.1.44-46.13
Berkoz, M.; Yalin, S.; Comelekoglu, U.; Bagis, S. Effect of calcitonin on lipid peroxidation in ovariectomized rats. Eur. J. Chem. 2010, 1(1), 44-46. doi:10.5155/eurjchem.1.1.44-46.13
Berkoz, M., Yalin, S., Comelekoglu, U., & Bagis, S. (2010). Effect of calcitonin on lipid peroxidation in ovariectomized rats. European Journal of Chemistry, 1(1), 44-46. doi:10.5155/eurjchem.1.1.44-46.13
Berkoz, Mehmet, Serap Yalin, Ulku Comelekoglu, & Selda Bagis. "Effect of calcitonin on lipid peroxidation in ovariectomized rats." European Journal of Chemistry [Online], 1.1 (2010): 44-46. Web. 21 Sep. 2019
Berkoz, Mehmet, Yalin, Serap, Comelekoglu, Ulku, AND Bagis, Selda. "Effect of calcitonin on lipid peroxidation in ovariectomized rats" European Journal of Chemistry [Online], Volume 1 Number 1 (31 March 2010)

DOI Link: https://doi.org/10.5155/eurjchem.1.1.44-46.13

Refbacks

  • There are currently no refbacks.




Copyright (c)




© Copyright 2019  Atlanta Publishing House LLC All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2019 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 4614 Lavista road, Tucker, GA, 30084, USA. Registered in USA.