European Journal of Chemistry 2010, 1(1), 44-46 | doi: https://doi.org/10.5155/eurjchem.1.1.44-46.13 | Get rights and content

Issue cover





  Open Access OPEN ACCESS | Open Access PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS

Effect of calcitonin on lipid peroxidation in ovariectomized rats


Mehmet Berkoz (1) , Serap Yalin (2,*) , Ulku Comelekoglu (3) , Selda Bagis (4)

(1) Department of Pharmaceutical Technology, Faculty of Pharmacy, Mersin University, Mersin, TR­33343, Turkey
(2) Department of Biochemistry, Faculty of Pharmacy, Mersin University, Mersin, TR­33343, Turkey
(3) Department of Biophysics, Medical School, Mersin University Mersin, TR­33343, Turkey
(4) Department of Physical Medicine and Rehabilitation, Medical School, Baskent University, Adana, TR­01150, Turkey
(*) Corresponding Author

Received: 24 Mar 2010 | Accepted: 24 Mar 2010 | Published: 31 Mar 2010 | Issue Date: March 2010

Abstract


Calcitonin is one of the active substances which is recently used effectively in osteoporosis treatment. In literature there is no information whether calcitonin cause oxidative stress or not. In this study, subcutaneous calcitonin is applied to rats having experimental postmenopausal osteoporosis and the effects of calcitonin on lipid peroxidation and antioxidant system were investigated. Forty-five healthy adult female Swiss albino Wistar rats were used in this study. The rats were divided into three equal groups as control, ovariectomized (Ovx) and ovariectomized+calcitonin (Ovx-CAL). The rats in Ovx and Ovx-CAL were anaesthetized and underwent a bilateral ovariectomy via ventral incision. Ten weeks after ovariectomy, salmon calcitonin (2 IU/kg body weight) was administered via s.c. at a volume of 1 mL per week for 12 weeks to the Ovx-CAL group. At the end of the drug treatment, livers and kidneys of rats were removed and malondialdehyde (MDA) levels and catalase (CAT) activities were determined by biochemical analysis methods. Data were analyzed by one-way ANOVA followed by the post-hoc LSD multiple test. The liver and kidney MDA levels were increased whereas the activity of CAT enzyme was decreased as a result of ovariectomy compared to values in the control group. Similar results were observed in Ovx-CAL group; however, the decline in the CAT activity in the kidney was not significant. In conclusion, we may suggest that calcitonin treatment increases the oxidative stress in osteoporotic rats.

1_1_44_46_800


Announcements


One of our sponsors will cover the article processing fee for all submissions made between May 17, 2023 and June 16, 2023 (Voucher code: SPONSOR2023).

Editor-in-Chief
European Journal of Chemistry

Keywords


Osteoporosis; oxidative stress; antioxidant; ovariectomy; calcitonin

Full Text:

PDF
PDF    Open Access

DOI: 10.5155/eurjchem.1.1.44-46.13

Links for Article


| | | | | | |

| | | | | | |

| | | |

Related Articles




Article Metrics

icon graph This Abstract was viewed 1171 times | icon graph PDF Article downloaded 523 times


Citations

/


[1]. Wale Johnson Adeyemi, Luqman Aribidesi Olayaki
Synergistic and non-synergistic effects of salmon calcitonin and omega - 3 fatty acids on antioxidant, anti-inflammatory, and haematological indices in diabetic rats
Biomedicine & Pharmacotherapy  99, 867, 2018
DOI: 10.1016/j.biopha.2018.01.085
/


[2]. Wale Johnson Adeyemi, Luqman Aribidesi Olayaki
Calcitonin and Omega–3 Fatty Acids Exhibit Antagonistic and Non-Additive Effects in Experimental Diabetes
Pathophysiology  25(2), 117, 2018
DOI: 10.1016/j.pathophys.2018.02.003
/


[3]. Wale Johnson Adeyemi, Luqman Aribidesi Olayaki
Effects of salmon calcitonin and omega – 3 fatty acids on selected biomarkers in experimental diabetic – osteoarthritic rats
Synergy  8, 100045, 2019
DOI: 10.1016/j.synres.2018.100045
/


References


[1]. Song, Y.; Liebschner, M. A.; Gunaratne, G. H. Biophys. J. 2004, 87, 3642-3647.
doi:10.1529/biophysj.104.044511
PMid:15377523    PMCid:1304878

[2]. Grynpas, M. D.; Huckell, B.; Pritzker, K. P.; Hancock, R. G.; Kessler, M. J. P. R. Health Sci. J. 1989, 8, 197-204.

[3]. Recker, R. R. Proc. Soc. Exp. Biol. Med. 1989, 191, 272-274.
PMid:2740358

[4]. Khosla, S. J. Clin. Endocrinol. Metab. 2010, 95, 3-10.
doi:10.1210/jc.2009-1740

[5]. Davidson, M. R. J. Midwifery Wom. Heal. 2003, 48, 39-52.
doi:10.1016/S1526-9523(02)00359-8
PMid:17571623

[6]. Theodorou, D. J.; Theodorou, S. J.; Sartoris, D. J. Compr. Ther. 2002, 28, 109-122.
doi:10.1007/s12019-002-0048-2
PMid:12085458

[7]. Pazzaglia, U. E.; Zatti, G.; Di Nucci, A.; Coci, A. Calcif. Tissue Int. 1993, 52, 125-129.
doi:10.1007/BF00308321
PMid:8443688

[8]. Plosker, G. L.; McTavish, D. Drugs Aging. 1996, 8, 378-400.
doi:10.2165/00002512-199608050-00006

[9]. Mehta, N. M.; Malootian, A.; Gilligan, J. P. Curr. Pharm. Des. 2003, 9, 2659-2676.
doi:10.2174/1381612033453622
PMid:14529539

[10]. El-Hajj Fuleihan, G. J. Med. Liban. 1998, 46, 23-28.
PMid:9795519

[11]. Rizer, M. K. Prim. Care. 2006, 33, 943-951.
doi:10.1016/j.pop.2006.09.004
PMid:17169675

[12]. Hawker, G. A. J. Rheumatol. Suppl. 1996, 45, 2-5.

[13]. Kulak, C. A.; Bilezikian, J. P. Int. J. Fertil. Womens Med. 1998, 43, 56-64.
PMid:9609204

[14]. Rao, L. G. Endocrinology Rounds. 2005, 5, 7-12.

[15]. Rao, L. G.; Guns, E.; Rao, A. V. Agro. Food Ind. Hi Tec. 2003, 14, 25-30,

[16]. Yalin, S.; Bagis, S.; Polat, G.; Dogruer, N.; Cenk, Aksit, S.; Hatungil, R.; Erdogan, C. Clin. Exp. Rheumatol. 2005, 23, 689-692.
PMid:16173248

[17]. Yagi, K. Methods Mol. Biol. 1998, 108, 101-106.
PMid:9921519

[18]. Aebi, H. Methods Enzymol. 1984, 105, 121-126.
doi:10.1016/S0076-6879(84)05016-3

[19]. Lowry, O. H.; Rosebrough, N. J.; Farr, A. L.; Randall, R. J. J. Biol. Chem. 1951, 193, 265-275.

[20]. Yalin, S.; Comelekoglu, U.; Bagis, S.; Sahin, N. O.; Ogenler, O.; Hatungil, R. Ecotoxicol. Environ. Saf. 2006, 65, 140-144.
doi:10.1016/j.ecoenv.2005.06.006
PMid:16095692

[21]. Kume-Kick, J.; Ferris, D. C.; Russo-Menna, I.; Rice, M. E. Brain Res. 1996, 738, 8-14.
doi:10.1016/0006-8993(96)00744-5

[22]. Borrás, C.; Sastre, J.; García-Sala, D.; Lloret, A.; Pallardó, F. V.; Viña, J. Free Radic. Biol. Med. 2003, 34, 546-552.
doi:10.1016/S0891-5849(02)01356-4

[23]. Muthusami, S.; Ramachandran, I.; Muthusami, B.; Vasudevan, G.; Prabhu, V.; Subramaniam, V.; Jagadeesan, A.; Narasimhan, S. Clin. Chim. Acta. 2005, 360, 81-86.
doi:10.1016/j.cccn.2005.04.014
PMid:15970279

[24]. Sreelathakumari, K. T., Menon, V. P.; Leelamma, S. Indian J. Med. Res. 1993, 98, 305-308.
PMid:8132235

[25]. Dombrecht, E. J.; Cos, P.; Vanden, Berghe, D.; Van Offel, J. F.; Schuerwegh, A. J.; Bridts, C. H.; Stevens, W. J.; De Clerck, L.S. Biochem. Biophys. Res. Commun. 2004, 314, 675-680.
doi:10.1016/j.bbrc.2003.12.149
PMid:14741688

[26]. Dombrecht, E. J.; De Tollenaere, C. B.; Aerts, K.; Cos, P.; Schuerwegh, A. J.; Bridts, C. H.; Van Offel, J. F.; Ebo, D. G.; Stevens, W. J.; De Clerck, L. S. Biochem. Biophys. Res. Commun. 2006, 348, 459-464.
doi:10.1016/j.bbrc.2006.07.075
PMid:16884693

[27]. Ozgocmen, S.; Kaya, H.; Fadillioglu, E.; Yilmaz, Z. Arch. Med. Res. 2007, 38, 196-205.
doi:10.1016/j.arcmed.2006.09.010
PMid:17227729

[28]. Ozgonul, M.; Oge, A.; Sezer, E. D.; Bayraktar, F.; Sozmen, E. Y. Endocr. Res. 2003, 29, 183-189.
doi:10.1081/ERC-120022299

[29]. Karsdal, M. A.; Henriksen, K.; Arnold, M.; Christiansen, C. BioDrugs. 2008, 22, 137-144.
doi:10.2165/00063030-200822030-00001
PMid:18481897

[30]. Chesnut, C. H.; Azria, M.; Silverman, S.; Engelhardt, M.; Olson, M.; Mindeholm, L. Osteoporos. Int. 2008, 19, 479-491.
doi:10.1007/s00198-007-0490-1
PMid:18071651


How to cite


Berkoz, M.; Yalin, S.; Comelekoglu, U.; Bagis, S. Eur. J. Chem. 2010, 1(1), 44-46. doi:10.5155/eurjchem.1.1.44-46.13
Berkoz, M.; Yalin, S.; Comelekoglu, U.; Bagis, S. Effect of calcitonin on lipid peroxidation in ovariectomized rats. Eur. J. Chem. 2010, 1(1), 44-46. doi:10.5155/eurjchem.1.1.44-46.13
Berkoz, M., Yalin, S., Comelekoglu, U., & Bagis, S. (2010). Effect of calcitonin on lipid peroxidation in ovariectomized rats. European Journal of Chemistry, 1(1), 44-46. doi:10.5155/eurjchem.1.1.44-46.13
Berkoz, Mehmet, Serap Yalin, Ulku Comelekoglu, & Selda Bagis. "Effect of calcitonin on lipid peroxidation in ovariectomized rats." European Journal of Chemistry [Online], 1.1 (2010): 44-46. Web. 3 Jun. 2023
Berkoz, Mehmet, Yalin, Serap, Comelekoglu, Ulku, AND Bagis, Selda. "Effect of calcitonin on lipid peroxidation in ovariectomized rats" European Journal of Chemistry [Online], Volume 1 Number 1 (31 March 2010)

The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item



DOI Link: https://doi.org/10.5155/eurjchem.1.1.44-46.13


CrossRef | Scilit | GrowKudos | Researchgate | Publons | ScienceGate | Scite | Lens | OUCI

WorldCat Paperbuzz | LibKey Citeas | Dimensions | Semanticscholar | Plumx | Kopernio | Zotero | Mendeley

ZoteroSave to Zotero MendeleySave to Mendeley



European Journal of Chemistry 2010, 1(1), 44-46 | doi: https://doi.org/10.5155/eurjchem.1.1.44-46.13 | Get rights and content

Refbacks

  • There are currently no refbacks.




Copyright (c)





© Copyright 2010 - 2023  Atlanta Publishing House LLC All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2010-2023 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.