European Journal of Chemistry 2010, 1(1), 44-46 | doi: https://doi.org/10.5155/eurjchem.1.1.44-46.13 | Get rights and content






  OPEN ACCESS | PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS

Effect of calcitonin on lipid peroxidation in ovariectomized rats


Mehmet Berkoz (1) , Serap Yalin (2,*) , Ulku Comelekoglu (3) , Selda Bagis (4)

(1) Department of Pharmaceutical Technology, Faculty of Pharmacy, Mersin University, Mersin, TR­33343, Turkey
(2) Department of Biochemistry, Faculty of Pharmacy, Mersin University, Mersin, TR­33343, Turkey
(3) Department of Biophysics, Medical School, Mersin University Mersin, TR­33343, Turkey
(4) Department of Physical Medicine and Rehabilitation, Medical School, Baskent University, Adana, TR­01150, Turkey
(*) Corresponding Author

Received: 24 Mar 2010 | Accepted: 24 Mar 2010 | Published: 31 Mar 2010 | Issue Date: March 2010

Abstract


Calcitonin is one of the active substances which is recently used effectively in osteoporosis treatment. In literature there is no information whether calcitonin cause oxidative stress or not. In this study, subcutaneous calcitonin is applied to rats having experimental postmenopausal osteoporosis and the effects of calcitonin on lipid peroxidation and antioxidant system were investigated. Forty-five healthy adult female Swiss albino Wistar rats were used in this study. The rats were divided into three equal groups as control, ovariectomized (Ovx) and ovariectomized+calcitonin (Ovx-CAL). The rats in Ovx and Ovx-CAL were anaesthetized and underwent a bilateral ovariectomy via ventral incision. Ten weeks after ovariectomy, salmon calcitonin (2 IU/kg body weight) was administered via s.c. at a volume of 1 mL per week for 12 weeks to the Ovx-CAL group. At the end of the drug treatment, livers and kidneys of rats were removed and malondialdehyde (MDA) levels and catalase (CAT) activities were determined by biochemical analysis methods. Data were analyzed by one-way ANOVA followed by the post-hoc LSD multiple test. The liver and kidney MDA levels were increased whereas the activity of CAT enzyme was decreased as a result of ovariectomy compared to values in the control group. Similar results were observed in Ovx-CAL group; however, the decline in the CAT activity in the kidney was not significant. In conclusion, we may suggest that calcitonin treatment increases the oxidative stress in osteoporotic rats.

1_1_44_46_800


Keywords


Osteoporosis; oxidative stress; antioxidant; ovariectomy; calcitonin

Full Text:

PDF /    /


DOI: 10.5155/eurjchem.1.1.44-46.13

Links for Article


| | | | |

| | | | | | |

Related Articles




Article Metrics

This Abstract was viewed 652 times | PDF Article downloaded 243 times


Citations

/


[1]. Wale Johnson Adeyemi, Luqman Aribidesi Olayaki
Synergistic and non-synergistic effects of salmon calcitonin and omega - 3 fatty acids on antioxidant, anti-inflammatory, and haematological indices in diabetic rats
Biomedicine & Pharmacotherapy  99, 867, 2018
DOI: 10.1016/j.biopha.2018.01.085
/


[2]. Wale Johnson Adeyemi, Luqman Aribidesi Olayaki
Calcitonin and Omega–3 Fatty Acids Exhibit Antagonistic and Non-Additive Effects in Experimental Diabetes
Pathophysiology  25(2), 117, 2018
DOI: 10.1016/j.pathophys.2018.02.003
/


[3]. Wale Johnson Adeyemi, Luqman Aribidesi Olayaki
Effects of salmon calcitonin and omega – 3 fatty acids on selected biomarkers in experimental diabetic – osteoarthritic rats
Synergy  8, 100045, 2019
DOI: 10.1016/j.synres.2018.100045
/


References

[1]. Song, Y.; Liebschner, M. A.; Gunaratne, G. H. Biophys. J. 2004, 87, 3642-3647.
doi:10.1529/biophysj.104.044511
PMid:15377523    PMCid:1304878

[2]. Grynpas, M. D.; Huckell, B.; Pritzker, K. P.; Hancock, R. G.; Kessler, M. J. P. R. Health Sci. J. 1989, 8, 197-204.

[3]. Recker, R. R. Proc. Soc. Exp. Biol. Med. 1989, 191, 272-274.
PMid:2740358

[4]. Khosla, S. J. Clin. Endocrinol. Metab. 2010, 95, 3-10.
doi:10.1210/jc.2009-1740

[5]. Davidson, M. R. J. Midwifery Wom. Heal. 2003, 48, 39-52.
doi:10.1016/S1526-9523(02)00359-8
PMid:17571623

[6]. Theodorou, D. J.; Theodorou, S. J.; Sartoris, D. J. Compr. Ther. 2002, 28, 109-122.
doi:10.1007/s12019-002-0048-2
PMid:12085458

[7]. Pazzaglia, U. E.; Zatti, G.; Di Nucci, A.; Coci, A. Calcif. Tissue Int. 1993, 52, 125-129.
doi:10.1007/BF00308321
PMid:8443688

[8]. Plosker, G. L.; McTavish, D. Drugs Aging. 1996, 8, 378-400.
doi:10.2165/00002512-199608050-00006

[9]. Mehta, N. M.; Malootian, A.; Gilligan, J. P. Curr. Pharm. Des. 2003, 9, 2659-2676.
doi:10.2174/1381612033453622
PMid:14529539

[10]. El-Hajj Fuleihan, G. J. Med. Liban. 1998, 46, 23-28.
PMid:9795519

[11]. Rizer, M. K. Prim. Care. 2006, 33, 943-951.
doi:10.1016/j.pop.2006.09.004
PMid:17169675

[12]. Hawker, G. A. J. Rheumatol. Suppl. 1996, 45, 2-5.

[13]. Kulak, C. A.; Bilezikian, J. P. Int. J. Fertil. Womens Med. 1998, 43, 56-64.
PMid:9609204

[14]. Rao, L. G. Endocrinology Rounds. 2005, 5, 7-12.

[15]. Rao, L. G.; Guns, E.; Rao, A. V. Agro. Food Ind. Hi Tec. 2003, 14, 25-30,

[16]. Yalin, S.; Bagis, S.; Polat, G.; Dogruer, N.; Cenk, Aksit, S.; Hatungil, R.; Erdogan, C. Clin. Exp. Rheumatol. 2005, 23, 689-692.
PMid:16173248

[17]. Yagi, K. Methods Mol. Biol. 1998, 108, 101-106.
PMid:9921519

[18]. Aebi, H. Methods Enzymol. 1984, 105, 121-126.
doi:10.1016/S0076-6879(84)05016-3

[19]. Lowry, O. H.; Rosebrough, N. J.; Farr, A. L.; Randall, R. J. J. Biol. Chem. 1951, 193, 265-275.

[20]. Yalin, S.; Comelekoglu, U.; Bagis, S.; Sahin, N. O.; Ogenler, O.; Hatungil, R. Ecotoxicol. Environ. Saf. 2006, 65, 140-144.
doi:10.1016/j.ecoenv.2005.06.006
PMid:16095692

[21]. Kume-Kick, J.; Ferris, D. C.; Russo-Menna, I.; Rice, M. E. Brain Res. 1996, 738, 8-14.
doi:10.1016/0006-8993(96)00744-5

[22]. Borrás, C.; Sastre, J.; García-Sala, D.; Lloret, A.; Pallardó, F. V.; Viña, J. Free Radic. Biol. Med. 2003, 34, 546-552.
doi:10.1016/S0891-5849(02)01356-4

[23]. Muthusami, S.; Ramachandran, I.; Muthusami, B.; Vasudevan, G.; Prabhu, V.; Subramaniam, V.; Jagadeesan, A.; Narasimhan, S. Clin. Chim. Acta. 2005, 360, 81-86.
doi:10.1016/j.cccn.2005.04.014
PMid:15970279

[24]. Sreelathakumari, K. T., Menon, V. P.; Leelamma, S. Indian J. Med. Res. 1993, 98, 305-308.
PMid:8132235

[25]. Dombrecht, E. J.; Cos, P.; Vanden, Berghe, D.; Van Offel, J. F.; Schuerwegh, A. J.; Bridts, C. H.; Stevens, W. J.; De Clerck, L.S. Biochem. Biophys. Res. Commun. 2004, 314, 675-680.
doi:10.1016/j.bbrc.2003.12.149
PMid:14741688

[26]. Dombrecht, E. J.; De Tollenaere, C. B.; Aerts, K.; Cos, P.; Schuerwegh, A. J.; Bridts, C. H.; Van Offel, J. F.; Ebo, D. G.; Stevens, W. J.; De Clerck, L. S. Biochem. Biophys. Res. Commun. 2006, 348, 459-464.
doi:10.1016/j.bbrc.2006.07.075
PMid:16884693

[27]. Ozgocmen, S.; Kaya, H.; Fadillioglu, E.; Yilmaz, Z. Arch. Med. Res. 2007, 38, 196-205.
doi:10.1016/j.arcmed.2006.09.010
PMid:17227729

[28]. Ozgonul, M.; Oge, A.; Sezer, E. D.; Bayraktar, F.; Sozmen, E. Y. Endocr. Res. 2003, 29, 183-189.
doi:10.1081/ERC-120022299

[29]. Karsdal, M. A.; Henriksen, K.; Arnold, M.; Christiansen, C. BioDrugs. 2008, 22, 137-144.
doi:10.2165/00063030-200822030-00001
PMid:18481897

[30]. Chesnut, C. H.; Azria, M.; Silverman, S.; Engelhardt, M.; Olson, M.; Mindeholm, L. Osteoporos. Int. 2008, 19, 479-491.
doi:10.1007/s00198-007-0490-1
PMid:18071651

How to cite


Berkoz, M.; Yalin, S.; Comelekoglu, U.; Bagis, S. Eur. J. Chem. 2010, 1(1), 44-46. doi:10.5155/eurjchem.1.1.44-46.13
Berkoz, M.; Yalin, S.; Comelekoglu, U.; Bagis, S. Effect of calcitonin on lipid peroxidation in ovariectomized rats. Eur. J. Chem. 2010, 1(1), 44-46. doi:10.5155/eurjchem.1.1.44-46.13
Berkoz, M., Yalin, S., Comelekoglu, U., & Bagis, S. (2010). Effect of calcitonin on lipid peroxidation in ovariectomized rats. European Journal of Chemistry, 1(1), 44-46. doi:10.5155/eurjchem.1.1.44-46.13
Berkoz, Mehmet, Serap Yalin, Ulku Comelekoglu, & Selda Bagis. "Effect of calcitonin on lipid peroxidation in ovariectomized rats." European Journal of Chemistry [Online], 1.1 (2010): 44-46. Web. 19 Feb. 2020
Berkoz, Mehmet, Yalin, Serap, Comelekoglu, Ulku, AND Bagis, Selda. "Effect of calcitonin on lipid peroxidation in ovariectomized rats" European Journal of Chemistry [Online], Volume 1 Number 1 (31 March 2010)

DOI Link: https://doi.org/10.5155/eurjchem.1.1.44-46.13

| | | | |

| | | | | |

Save to Zotero Save to Mendeley



European Journal of Chemistry 2010, 1(1), 44-46 | doi: https://doi.org/10.5155/eurjchem.1.1.44-46.13 | Get rights and content

Refbacks

  • There are currently no refbacks.




Copyright (c)




© Copyright 2019  Atlanta Publishing House LLC All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2019 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 4614 Lavista road, Tucker, GA, 30084, USA. Registered in USA.

hatay escort hatay escort corlu escort corum escort burgaz escort giresun escort aydin escort ordu escort erzincan escort hatay escort sivas escort rize escort edirne escort aksaray escort kibris escort isparta escort erzurum escort tekirdag escort usak escort urfa escort kastamonu escort kibris escort manisa escort giresun escort urfa escort nevsehir escort sivas escort yalova escort ordu escort hatay escort yalova escort amasya escort kayseri escort ordu escort maras escort canakkale escort yalova escort balikesir escort manisa escort urfa escort mugla escort trabzon escort bolu escort corlu escort diyarbakir escort isparta escort kutahya escort elazig escort erzurum escort sakarya escort afyon escort kutahya escort konya escort agri escort cesme escort sinop escort sivas escort konya escort kibris escort adapazari escort luleburgaz escort adana escort kibris escort rize escort sakarya escort alanya escort isparta escort burdur escort konya escort bitlis escort canakkale escort sivas escort amasya escort mus escort aydin escort van escort yalova escort kastamonu escort mardin escort bolu escort afyon escort sakarya escort isparta escort tokat escort trakya escort bayburt escort urfa escort mardin escort