European Journal of Chemistry 2016, 7(1), 37-41. doi:10.5155/eurjchem.7.1.37-41.1355

Simultaneous determination of carbinoxamine maleate and pseudoephedrine HCl in their pure form and in their pharmaceutical formulation by HPTLC-densitometric method


Maha Mohamed Abdelrahman (1) , Eglal Abdelhameed Abdelaleem (2) , Nouruddin Wageih Ali (3) , Raghda Abdelmoneim Emam (4,*)

(1) Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni- Suef University, 62514, Beni-Suef, Egypt
(2) Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni- Suef University, 62514, Beni-Suef, Egypt
(3) Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni- Suef University, 62514, Beni-Suef, Egypt
(4) Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni- Suef University, 62514, Beni-Suef, Egypt
(*) Corresponding Author

Received: 14 Nov 2015, Accepted: 16 Dec 2015, Published: 31 Mar 2016

Abstract


An accurate, sensitive and selective High Performance Thin Layer Chromatography (HPTLC) method has been developed and validated for determination of carbinoxamine maleate and pseudoephedrine HCl in their binary mixture without previous separation. Chromatographic separation was performed on aluminum plates precoated with silica gel 60F254 using acetone: methanol:ethylacetate:triethylamine (5:4:2:0.2, v:v:v:v) as a developing system. The bands were scanned at 215 nm. The proposed method has been validated as per ICH guidelines and its linearity was evident in the ranges of 0.4-8.0 and 4-24 µg/ band for carbinoxamine maleate and pseudoephedrine HCl, respectively. The developed method has been applied for determination of the above mentioned drugs in their pharmaceutical formulation where no interference from methyl paraben present as excipient has been detected. Statistical comparison of the results obtained by the developed HPTLC method and those obtained by the reported HPLC method showed no significant difference between them. The developed method is sensitive, accurate and precise and can be easily used for quality control analysis of the studied drugs.


Keywords


Validation; Methyl paraben; Pseudoephedrine HCl; HPTLC-densitometry; Carbinoxamine maleate; Pharmaceutical formulation

Full Text:

PDF /    /


DOI: 10.5155/eurjchem.7.1.37-41.1355

Article Metrics


This Abstract was viewed 579 times | PDF Article downloaded 229 times

Citations

/


[1]. Souha Hosam Youssef, Dalia Mohamed, Maha Abdel Monem Hegazy, Amr Badawey
Analytical methods for the determination of paracetamol, pseudoephedrine and brompheniramine in Comtrex tablets
BMC Chemistry  13(1), , 2019
DOI: 10.1186/s13065-019-0595-6
/


[2]. Fatma Ahmed Aly, Nahed EL-Enany, Heba Elmansi, Amany Nabil
A fast spectrofluorimetric method for determination of carbinoxamine maleate in the nano-molar range. Application to pharmaceutical preparations, biological fluids and stability studies
Analytical Methods  10(31), 3851, 2018
DOI: 10.1039/C8AY01202D
/


References

[1]. Martindale: The complete drug reference, The Extra Pharmacopoeia, 35th edition, London: Pharmaceutical Press, 2007.

[2]. BP, The British Pharmacopoeia, Her Majesty's, The Stationary Office, London, 2007.

[3]. Ramadan, A. A.; Mandil, H. Anal. Biochem. 2006, 353(1), 133-137.
http://dx.doi.org/10.1016/j.ab.2006.02.020

[4]. Mosconi, L. Analyst 1968, 93, 326-327.
http://dx.doi.org/10.1039/an9689300326

[5]. Shoukrallah, I. Anal. Lett. 1991, 24(11), 2043-2058.
http://dx.doi.org/10.1080/00032719108053032

[6]. Palabiyik, I. M.; Feyyaz, O. J. Anal. Chem. 2012, 67(1), 56-63.
http://dx.doi.org/10.1134/S1061934812010066

[7]. Carina de, A. B.; Marcone, A. L. Quim. Nova 2009, 32(7), 225-228.

[8]. Gurupadayya, B. M.; Bhavani, B. G.; Sharfuddin, S. IOSR J. Appl. Chem. 2014, 6(6), 46-51.
http://dx.doi.org/10.9790/5736-0664651

[9]. Hoffman, D. J.; Leveque, M. J.; Thomson, T. J. Pharm. Sci. 1983, 72(11), 1342-1344.
http://dx.doi.org/10.1002/jps.2600721126

[10]. Hussain, K. R.; Mahesh, N.; Prasad, V. V. L. N.; Prakash, V. D. Bri. J. Pharm. Res. 2014, 4(4), 16-19.

[11]. Sahu, R.; Sharma, H. K.; Sahu, V.; Tripathi, S.; Jain, N. Int. J. Res. Pharm. & Sci. 2011, 1(3), 42-47.

[12]. Monferrer-Pons, L.; Esteve-Romero, J. S.; Ramis-Ramos, G.; Garcia-Alvarez-Coque, M. C. Anal. Lett. 1996, 29(8), 1399-1413.
http://dx.doi.org/10.1080/00032719608001490

[13]. Ali, M. S.; Ghori, M.; Rafiuddin, S.; Khatri, A. R. J. Pharm. Biomed. Anal. 2007, 43(1), 158-167.
http://dx.doi.org/10.1016/j.jpba.2006.06.038

[14]. Gu, X.; Li, H.; Macnair, K. R.; Simons, F. E.; Simons, K. J. J. Pharm. Biomed. Anal. 2005, 37(4), 663-667.
http://dx.doi.org/10.1016/j.jpba.2004.10.054

[15]. Louhaichi, M. R.; Jebali, S.; Loueslati, M. H.; Adhoum, N.; Monser, N. Talanta 2009, 78, 991-997.
http://dx.doi.org/10.1016/j.talanta.2009.01.019

[16]. Shervington, L. A. Anal. Lett. 1997, 30, 927-944.
http://dx.doi.org/10.1080/00032719708002307

[17]. Altuntas, T. G.; Zanooz, S. S.; Nebioglu, D. J. Pharm. Biomed. Anal. 1998, 17(1), 103-109.
http://dx.doi.org/10.1016/S0731-7085(97)00148-9

[18]. Leroy, A. S.; Al-Omari, M.; Abdoh, A. Saudi Pharmaceut. J. 1998, 53-59.

[19]. Mansour, A. M. J. AOAC Int. 1998, 81(5), 958-962.

[20]. Mehta, B. H.; Morge, S. B. J. Planar Chromatogr. 2008, 21(3), 173-176.
http://dx.doi.org/10.1556/JPC.21.2008.3.3

[21]. Sathe, S. R.; Bari, S. B. Acta Chromatogr. 2007, 19, 270-278.

[22]. Nouruddin, W. A.; Maha, M. A.; Eglal, A. A. J. Planar Chromatogr. 2012, 25(2), 151-156.

[23]. Hussien, E. M.; Ibrahim, M. M.; Issa, Y. M.; Abdel-Gawad, F. M.; Barakat, S. Int. J. Drug Dev. Res. 2011, 3, 168-177.

[24]. Ali, N. W.; Abdelwahab, N. S.; Abdelkawy, M.; Emam, A. A. J. Chromatogr. Sci. 2014, 52(1), 5-11.
http://dx.doi.org/10.1093/chromsci/bms197

[25]. Abdelaleem, E. A.; Abdelwahab, N. S. J. Chromatogr. Sci. 2013, 51(2), 187-191.
http://dx.doi.org/10.1093/chromsci/bms125

[26]. Wagieh, N. E.; Abbas, S. S.; Abdelkawy, M.; Abdelrahman, M. M. Drug Test. Anal. 2010, 2(3), 113-121.

[27]. Naguib, I. A.; Abdelaleem, E. A.; Zaazaa, H. E.; Hussein, E. A. E. Eur. J. Chem. 2014, 5(2), 219-226.
http://dx.doi.org/10.5155/eurjchem.5.2.219-226.966

[28]. ICH, Q2 (R1) Validation of Analytical Procedures, Proceedings of the International Conference on Harmonization, Geneva, 2005.

[29]. The United States Pharmacopeia and National Formulary, USP 30-NF, The Official Compenia of Standards, Asian Edition, The United States Pharmacopeial Convention Inc. Rockville, Md., 2007.


How to cite


Abdelrahman, M.; Abdelaleem, E.; Ali, N.; Emam, R. Eur. J. Chem. 2016, 7(1), 37-41. doi:10.5155/eurjchem.7.1.37-41.1355
Abdelrahman, M.; Abdelaleem, E.; Ali, N.; Emam, R. Simultaneous determination of carbinoxamine maleate and pseudoephedrine HCl in their pure form and in their pharmaceutical formulation by HPTLC-densitometric method. Eur. J. Chem. 2016, 7(1), 37-41. doi:10.5155/eurjchem.7.1.37-41.1355
Abdelrahman, M., Abdelaleem, E., Ali, N., & Emam, R. (2016). Simultaneous determination of carbinoxamine maleate and pseudoephedrine HCl in their pure form and in their pharmaceutical formulation by HPTLC-densitometric method. European Journal of Chemistry, 7(1), 37-41. doi:10.5155/eurjchem.7.1.37-41.1355
Abdelrahman, Maha, Eglal Abdelhameed Abdelaleem, Nouruddin Wageih Ali, & Raghda Abdelmoneim Emam. "Simultaneous determination of carbinoxamine maleate and pseudoephedrine HCl in their pure form and in their pharmaceutical formulation by HPTLC-densitometric method." European Journal of Chemistry [Online], 7.1 (2016): 37-41. Web. 17 Sep. 2019
Abdelrahman, Maha, Abdelaleem, Eglal, Ali, Nouruddin, AND Emam, Raghda. "Simultaneous determination of carbinoxamine maleate and pseudoephedrine HCl in their pure form and in their pharmaceutical formulation by HPTLC-densitometric method" European Journal of Chemistry [Online], Volume 7 Number 1 (31 March 2016)

DOI Link: https://doi.org/10.5155/eurjchem.7.1.37-41.1355

Refbacks

  • There are currently no refbacks.




Copyright (c)




© Copyright 2019  Atlanta Publishing House LLC All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2019 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 4614 Lavista road, Tucker, GA, 30084, USA. Registered in USA.