European Journal of Chemistry

Spectrofluorimetric analysis of menbutone in veterinary formulations: Application to residue determination in bovine meat and milk



Main Article Content

Fathalla Belal
Sawsan Abdel-Moneim Abd El-Razeq
Manal Mohamed Fouad
Fatma Ahmed Fouad

Abstract

A simple, rapid, and sensitive spectroflourimetric method was developed for the determination of menbutone. The method is based on measuring the native fluorescence of the alkaline aqueous methanolic solution of the cited drug at its optimum excitation and emission wavelengths at λem 378 nm, upon excitation at λex 300 nm. The method showed good linearity over the range of 0.2-2.0 µg/mL with a detection and quantitation limits of 7.25 and 24.15 ng/mL, respectively. The suggested method was successfully applied to the analysis of menbutone in its commercial veterinary formulations and the results obtained were in good agreement with those given with the manufacturer method. The method was further extended to the determination of menbutone residues in bovine meat and milk, and the results were satisfactory. The recoveries obtained were in the 98.50-102.25% range. No organic solvents were used in the extraction procedures, therefore, the proposed method can be considered as a type of 'green' chemical process.


icon graph This Abstract was viewed 1596 times | icon graph Article PDF downloaded 685 times

How to Cite
(1)
Belal, F.; El-Razeq, S. A.-M. A.; Fouad, M. M.; Fouad, F. A. Spectrofluorimetric Analysis of Menbutone in Veterinary Formulations: Application to Residue Determination in Bovine Meat and Milk. Eur. J. Chem. 2016, 7, 156-160.

Article Details

Share
Crossref - Scopus - Google - European PMC
References

[1]. O' Neil, J. M. The Merck Index, 14th Ed., Merck and Co., Inc., Rahway, UDA, 2006.

[2]. Symonds, H.W. Vet. Rec. 1982, 110, 423-425.
http://dx.doi.org/10.1136/vr.110.18.423

[3]. Ackerman, L. Veterinary Practice Management, Black Well Publications, New Jersey, 2007.

[4]. Rodriguez, E.; Moreno-Bondi, M.C.; Marazuela, M.D. J. Chromatogr. A 2008, 1209, 136-144.
http://dx.doi.org/10.1016/j.chroma.2008.09.031

[5]. Lund, J.; Lassen, J. B. Acta Pharmacol. Toxicol. 1969, 27, 429-438.
http://dx.doi.org/10.1111/j.1600-0773.1969.tb00490.x

[6]. Fouad, M. M.; Abdel-Razeq, S. A.; Belal, F. F.; Fouad, F. A. Int. J. Pharm. Anal. 2013, 4, 30-35.

[7]. Luo, Y.; Tan, M.; Luo, L.; Wang, L.; Yang, Y.; Long, F.; Wang, S.; Wu, M. Faming Zhuanli Shenqing 2013, 12, 11-16.

[8]. Luo, Y.; Tan, M.; Luo, L.; Wang, L.; Yang, Y.; Long, F.; Wang, S.; Wu, M. Faming Zhuanli Shenqing 2013, 12, 4-10.

[9]. Belal, F.; Abdel-Razeq, S. A.; Fouad, M. M.; Zayed, S.; Fouad, F. A. Food Anal. Method 2016, 9, 638-645.
http://dx.doi.org/10.1007/s12161-015-0230-7

[10]. Shoichiro, N.; Hisaya, T. Nagoya-Shi Eisei Kenkyushoho 2008, 54, 1-5.

[11]. Hirosh, M.; Kouhei, F.; Toshiaki, T. Kumamoto-Ken Hoken Kankyo Kagaku Kenkyushoho 2010, 39, 21-25.

[12]. Nasr, J. J.; Shalan, S. Luminescence 2014, 29(8), 1188-1193.
http://dx.doi.org/10.1002/bio.2683

[13]. Belal, F.; Sharaf El-Din, M. K.; Tolba, M. M.; Elmansi, H. J. Fluorescence 2014, 24(1), 85-91.
http://dx.doi.org/10.1007/s10895-013-1273-z

[14]. Ayad, M. M.; Abdellatef, H. E.; Hosny, M. M.; Sharaf, Y. A. Eur. J. Chem. 2013, 4(1), 35-43.
http://dx.doi.org/10.5155/eurjchem.4.1.35-43.713

[15]. Munson, J. W. Pharmaceutical analysis, Part A, Marcel Dekker, Inc., New York, USA, 1981.

[16]. International Conference on Harmonization (ICH). Technical Requirements for the Registration of Pharmaceutical for Human Use, Validation of Analytical Procedures; Text and methodology Q2 (R1), Geneva, 2005.

[17]. Miller, J. N.; Miller, J. C. Statistics and chemometrics for analytical chemistry, 5th Ed., Pearson Education Limited, Harlow, England, 2005.

Supporting Agencies

The Unit of Drug Analysis at the Faculty of Pharmacy, Mansoura University, Mansoura,
Most read articles by the same author(s)

Most read articles by the same author(s)

TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).