

Voltammetric and viscometric studies of flavonoids interactions with DNA at physiological conditions
Syed Tajammul Hussain (1,*)


(1) National Centre for Physics, Quaid-i-Azam University, Islamabad, 44000, Pakistan
(2) National Centre for Physics, Quaid-i-Azam University, Islamabad, 44000, Pakistan
(*) Corresponding Author
Received: 04 Jun 2010 | Accepted: 08 Dec 2010 | Published: 28 Mar 2011 | Issue Date: March 2011
Abstract
Cyclic voltammetric behaviour of three flavonoids: quercetin, morin and rutin was investigated for their interaction with DNA at pH = 4.7 and pH = 7.4 at body temperature (310 K), using glassy carbon electrode. The diffusion coefficients of the free and DNA bound forms of the flavonoids were evaluated using Randles–Sevcik equation. The binding parameters like binding constant, binding site size and binding free energy were also determined from voltammetric data. Moreover, the binding modes of flavonoids with DNA were evaluated from viscommetric analysis. A comparatively high value of binding constant, binding site size and diffusion coefficients for quercetin reveals its stronger binding with DNA under physiological conditions. The negative values of ∆G indicate the spontaneity of binding of flavonoids with DNA.
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DOI: 10.5155/eurjchem.2.1.109-112.147
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Quaid-i-Azam University
Citations
[1]. Petar M. Mitrasinovic
Sequence-Dependent Binding of Flavonoids to Duplex DNA
Journal of Chemical Information and Modeling 55(2), 421, 2015
DOI: 10.1021/ci5006965

[2]. L. N. Grigoryan, Yu. V. Bataeva, E. D. Andreeva, D. Kh. Zakar’yaeva, Z. O. Turaeva, S. V. Antonova
Study of the Component Structure of the Metabolites of Bacteria Nocardiopsis umidischolae in the Search for Eco-Friendly Plant Protection Agents
Russian Journal of General Chemistry 90(13), 2531, 2020
DOI: 10.1134/S1070363220130010

[3]. Anna Masek, Ewa Chrzescijanska, Marian Zaborski
Electrooxidation of morin hydrate at a Pt electrode studied by cyclic voltammetry
Food Chemistry 148, 18, 2014
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[4]. D.A. Chernikov, T.A. Shishlyannikova, A.V. Kashevskii, B.N. Bazhenov, A.V. Kuzmin, A.G. Gorshkov, A.Y. Safronov
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Electrochimica Acta 271, 560, 2018
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RSC Advances 2(7), 2797, 2012
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Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 99, 329, 2012
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European Journal of Chemistry 7(3), 341, 2016
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DOI Link: https://doi.org/10.5155/eurjchem.2.1.109-112.147

















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