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Searching for anti-hyperglycemic phytomolecules of Tecoma stans
Mohamed Abdel-Hamid Taher (1,*)
, Dawood Hosni Dawood (2) , Mostafa Ibrahim Sanad (3) , Ramadan Ahmed Hassan (4) (1) Department of Agricultural Chemistry, Faculty of Agriculture, Mansoura University, Mansoura, 33516, Egypt
(2) Department of Agricultural Chemistry, Faculty of Agriculture, Mansoura University, Mansoura, 33516, Egypt
(3) Department of Agricultural Chemistry, Faculty of Agriculture, Mansoura University, Mansoura, 33516, Egypt
(4) Department of Agricultural Chemistry, Faculty of Agriculture, Mansoura University, Mansoura, 33516, Egypt
(*) Corresponding Author
Received: 18 Jul 2016 | Revised: 30 Aug 2016 | Accepted: 03 Sep 2016 | Published: 31 Dec 2016 | Issue Date: December 2016
Abstract
Tecoma stans plant is well postulated to decrease blood glucose level, but its mode of action and the molecules responsible are still controversial. Thus, the aim of this study was to evaluate the effect of leaves methanol extract of Tecoma stans and some of its fractions on starch tolerance in healthy rats, in vitro inhibition of α-amylase, and their effects of sub-chronic administration of glucose, lipid pattern, kidney and liver functions and antioxidant status in streptozotocin (STZ) induced diabetic rats. In starch tolerance experiment, both ethyl acetate and crude flavonoids fractions decreased glycemic peak values in healthy rats to extent similar to that of acarbose. In STZ sub-chronic experiment all preparations of Tecoma stans significantly decreased fasting glucose with variable degrees. The results indicated that the crude methanol extract had the most antidiabetic potential followed by the methylene chloride rich alkaloid fraction while the crude flavonoids fraction achieved the lowest effect. All Tecoma stans different preparations have positive effects on serum lipid pattern, kidney and liver function parameters, in addition to the antioxidant parameters (MDA and GSH) in liver tissues. In conclusion, the present study suggested that the alkaloids synergistically act as antidiabetic agent with other bioactive compounds of Tecoma stans especially flavonoids as hypoglycemic agents and the ethyl acetate fraction had the most powerful effects.
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DOI: 10.5155/eurjchem.7.4.397-404.1478
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Mansoura University, Mansoura, 33516, Egypt
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DOI: 10.1007/s11356-021-12781-5
[2]. Mukul Anand, Basavaraju R.
Chemical Composition and in vitro Antioxidant Potential of Tecoma stans (L.) Juss. ex Kunth
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DOI: 10.21048/IJND.2021.58.2.27602
[3]. Mukul Anand, R. Basavaraju
A review on phytochemistry and pharmacological uses of Tecoma stans (L.) Juss. ex Kunth
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DOI: 10.1016/j.jep.2020.113270
[4]. Thaís Paula Rodrigues Gonçalves, Adriano Guimarães Parreira, Vanessa Samúdio dos Santos Zanuncio, Katyuce de Souza Farias, Denise Brentan da Silva, Luciana Alves Rodrigues dos Santos Lima
Antibacterial and antioxidant properties of flowers from Tecoma stans (L.) Juss. ex Kunth (Bignoniaceae)
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DOI: 10.1016/j.sajb.2021.08.028
[5]. Tapan Behl, Amit Gupta, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Madhukar Garg, Saurabh Bhatia, Ahmed Al-Harrasi, Lotfi Aleya, Simona Bungau
Exploring the multifaceted role of TGF-β signaling in diabetic complications
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DOI: 10.1007/s11356-022-19499-y
[6]. Kim-Ngoc Ha, Tran-Van-Anh Nguyen, Dinh-Tri Mai, Nguyen-Minh-An Tran, Ngoc-Hong Nguyen, Giau Van Vo, Thuc-Huy Duong, Huy Truong Nguyen
Alpha-glucosidase inhibitors from Nervilia concolor, Tecoma stans, and Bouea macrophylla
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DOI: 10.1016/j.sjbs.2021.09.070
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Tecomastane, a new megastigmane from the flowers of Tecoma stans
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DOI: 10.1080/14786419.2022.2092735
[8]. Rodrigo Castañeda, Armando Cáceres, Sully M. Cruz, J. Agustín Aceituno, E. Sebastián Marroquín, Ana C. Barrios Sosa, Wendy K. Strangman, R. Thomas Williamson
Nephroprotective plant species used in traditional Mayan Medicine for renal-associated diseases
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DOI: 10.1016/j.jep.2022.115755
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DOI: 10.5155/eurjchem.8.2.105-108.1541
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DOI: 10.1007/s11033-021-06294-0
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Pharmacokinetic profile and sub-chronic toxicity of coenzyme Q10 loaded whey protein nanoparticles
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DOI: 10.1016/j.fbio.2022.102347
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DOI: 10.1080/10496475.2019.1666769
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DOI: 10.1016/j.foodchem.2018.05.099
[15]. Amit Gupta, Tapan Behl
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DOI: 10.2174/2210315510666191224114311
References
[1]. Veeramani, C.; Pushpavalli, G.; Pugalendi, K. V. J. Appl. Biomed. 2008, 6, 19-26.
[2]. Hernandez-Galicia, E.; Aguilar-Contreras, A.; Aguilar-Santamaria, L.; Roman-Ramos, R.; Chavez-Miranda, A. A.; Garcia-Vega, L. M.; Flores-Saenz, J. L.; Alarcon-Aguilar, F. J. Proc. West Pharmacol. Soc. 2002, 45, 118-124.
[3]. Perez, G. R. M.; Ocegueda, A. Z.; Munoz, J. L. L.; Avila, J. G. A.; Morrow, W. W. J. Ethnopharmacol. 1984, 12, 253-262.
http://dx.doi.org/10.1016/0378-8741(84)90054-0
[4]. Meckes-Lozoya, M.; Mellado-Campos, V. J. Ethnopharmacol. 1985, 14, 1-9.
http://dx.doi.org/10.1016/0378-8741(85)90022-4
[5]. Naranjo, D. L. P.; Salvado, M. C. J.; Jimenez, G. R.; Menendez, T. M. F.; Perez-Santoya, P. E. Rev. Cubana Med. Milit. 2003, 32(1), 13-17.
[6]. Aguilar, L. C.; Macias, S.; Chagoya, A.; Cardenas, A.; Diaz, P.; Cantu, J. M. Fitoterapia 1993, 64, 304-305.
[7]. Costantino, L.; Lins, A. P.; Barlocco, D.; Celotti, F.; ElAbady, S. A.; Brunetti, T.; Maggi, R.; Antolini, L. Pharmazie 2003, 58, 140-142.
[8]. Costantino, L.; Raimondi, L.; Pirisino, R.; Brunetti, T.; Pessotto, P.; Giannessi, F.; Lins, A. P.; Barlocco, D.; Antolini, L.; El-Abady, S. A. Il Farmaco 2003, 58, 781-785.
http://dx.doi.org/10.1016/S0014-827X(03)00133-2
[9]. Aguilar-Santamaria, L.; Ramirez, G.; Nicasio, P.; Alegria-Reyes, C.; Herrera-Arellano, A. J. Ethnopharmacol. 2009, 124, 284–288.
http://dx.doi.org/10.1016/j.jep.2009.04.033
[10]. Adaramoye, O.; Amanlou, M.; Habibi-Rezaei, M.; Pasalar, P.; Ali, M. M. Asian Pac. Trop. Med. 2012, 5, 427-433.
http://dx.doi.org/10.1016/S1995-7645(12)60073-X
[11]. Ibrahim, G. S.; Abdulmumin, K. Y.; Musa Yaro, A. H. J. Pharmacol. Toxicol. 2008, 3, 351-356.
http://dx.doi.org/10.3923/jpt.2008.351.356
[12]. Harborne, J. B. Phytochemical Methods, 2nd ed., Chapman and Hall publications, London, New York, 1988.
[13]. Lin, J. Y.; Tang, C. Y. Food Chem. 2007, 101, 140-147.
http://dx.doi.org/10.1016/j.foodchem.2006.01.014
[14]. Singleton, V. L.; Orthofer, R.; Lamuela-Raventos, R. M. Method. Enzymol. 1999, 299, 152-178.
http://dx.doi.org/10.1016/S0076-6879(99)99017-1
[15]. Mattila, P.; Astola, J.; Kumpulainen, J. J. Sci. Food. Agric. 2000, 48, 5834-5841.
http://dx.doi.org/10.1021/jf000661f
[16]. Goupy, P.; Hugues, M.; Boivin, P.; Amiot, M. J. J. Sci. Food Agric. 1999, 79, 1625-1634.
http://dx.doi.org/10.1002/(SICI)1097-0010(199909)79:12<1625::AID-JSFA411>3.0.CO;2-8
[17]. Hussain, S. J.; Tsujiyama, I.; Takasugi, M.; Islam, M. A.; Biswas, R. S.; Aoshima, H. Food Sci. Technol. Res. 2008, 14, 261-268.
http://dx.doi.org/10.3136/fstr.14.261
[18]. Ghasemi, M.; Sadeghipour, H.; Asadi, S.; Dehpour, D. Life Sci. 2007, 81, 960-969.
http://dx.doi.org/10.1016/j.lfs.2007.06.020
[19]. Orhan, D.; Aslan, M.; Orhan, D. D.; Ergun, F.; Yesilada, E. J. Ethnopharmacol. 2006, 108, 280-286.
http://dx.doi.org/10.1016/j.jep.2006.05.010
[20]. Rosclau, P.; Bernt, E.; Gruber, W. Zklin. Chem. Klin. Biochem. 1974, 12, 403-407.
[21]. Schettler, G.; Nussel, E. Sozialmed Praeventivmed 1975, 10, 25-29.
[22]. Friedewald, W. T.; Robert, I. L.; Donald, S. F. Clin. Chem. 1972, 18, 499-502.
[23]. Trinder, P. Ann. Clinc. Biochem. 1969, 6, 24-27.
http://dx.doi.org/10.1177/000456326900600108
[24]. Murray, R. L. Creatinine In: Clinical Chemistry; Theory, Analysis and Correlation, Kaplan, L. A. and Pesce, A.J. (Eds.), CV Mosby Company, St. Louis, 1984, pp. 1247-1253.
[25]. Fossati, P.; Prencipe, L.; Berti, G. Clin Chem. 1980, 26, 227-231.
[26]. Schultz, A. Clin Chem. 1984, 418, 1261-1266.
[27]. Henry, R. J.; Chiamori, N.; Golub, O. J.; Berkman, S. Am. J. Clin. Pathol. 1960, 34, 381-398.
[28]. Norbert, W. T. Clinical Guide to Laboratory Tests. Third ed. Saunders W. B. Company; Philadelphia, 1995.
[29]. Schulpis, K.; Karikas, G. A. Paediatrics 1998, 101, 861-864.
http://dx.doi.org/10.1542/peds.101.5.861
[30]. Draper, H. H.; Hadley, M. In: Parcker, L. & Glazer, A. ed. Method. Enzymol. New York, Academic Press, 1991, v. 186 (B), pp. 421-443.
[31]. Ellman, G. L. Arch. Biochem. Biophys. 1959, 82, 70-77.
http://dx.doi.org/10.1016/0003-9861(59)90090-6
[32]. Mohamed, Z. M. S.; Yousry, M. G.; Camacho, L. M.; El-Shanhorey, N. A.; Salem, A. Z. M. Afr. J. Microbio Res. 2013, 7, 418-426.
http://dx.doi.org/10.5897/AJMR12.2274
[33]. Dash, S.; Das, C.; Sahoo, D. C.; Sahoo, A. C. Nat. Pharm. Technol. 2011, 1, 5-8.
[34]. Ahmad, N.; Mukhtar, H. Nutr. Rev. 1999, 57, 78-83.
http://dx.doi.org/10.1111/j.1753-4887.1999.tb06927.x
[35]. Velioglu, Y. S.; Mazza, G.; Gao, L. J. Agric. Food Chem. 1998, 46(10), 4113-4117.
http://dx.doi.org/10.1021/jf9801973
[36]. Kamalakkannan, N.; Prince, P. S. Basic. Clin. Pharmacol. Toxicol. 2006, 98, 97-103.
http://dx.doi.org/10.1111/j.1742-7843.2006.pto_241.x
[37]. Oke-Altuntas, F.; Aslim, B.; Duman, H.; Gulpinar, A. R.; Kartal, M. J. Food Biochem. 2015, 39, 409-416.
http://dx.doi.org/10.1111/jfbc.12137
[38]. Ou, S.; Kwok. J. Sci. Food Agric. 2004, 84, 1261-1269.
http://dx.doi.org/10.1002/jsfa.1873
[39]. Bumrungpert, A.; Pingeesakikul, T.; Tirawanchai, N.; Tuntipopipat, S.; Lilitchan, S.; Komindr, S. Fed. Am. Soc. Exp. Bio. J. 2012, 26, 263-267.
[40]. Khan, M. T.; Lampronti, I.; Martello, D.; Bianchi, N.; Jabbar, S.; Choudhuri, M. S.; Datta, B. K.; Gambari, R. Int. J. Oncol. 2002, 21, 187-192.
[41]. Adisakwattana, S.; Yibchok-Anun, S.; Charoenlertkul, P.; Wongsasiripat, N. J. Clin. Biochem. Nutr. 2011, 49, 36-41.
http://dx.doi.org/10.3164/jcbn.10-116
[42]. Pashikanti, S.; de Alba, D. R.; Boissonneault, G. A.; Cervantes-Laurean, D. Free Radical Bio. Med. 2010, 48, 656-663.
http://dx.doi.org/10.1016/j.freeradbiomed.2009.11.019
[43]. Brahmachari, G. Opportunity, Challenge and Scope of Natural Products in Medicinal Chemistry, 1st edition, Chapter 6, Research Signpost, 2011, pp. 187-212.
http://dx.doi.org/10.1142/8033
[44]. Sattanathan, K.; Dhanapal, C. K.; Umarani, R.; Manavalan, R. J. Appl. Pharma. Sci. 2011, 1, 227-231.
[45]. Vessal, M.; Hemmati, M.; Vasie, M. Comp. Biochem. Physiol. Toxicol. Pharmacol. 2003, 135-357.
[46]. Coskun, O.; Kanter, M.; Korkmaz, A. and Oter, S. Pharmacol Res. 2005, 1, 117-123.
http://dx.doi.org/10.1016/j.phrs.2004.06.002
[47]. Brixova, E. Folia, Fac. Med. Univ. Comenian. Bratis. 1981, 19, 9-90.
[48]. Goldberg, R. B. Diabetes Care. 1981, 4, 561-572.
http://dx.doi.org/10.2337/diacare.4.5.561
[49]. Suckling, K. E.; Jackson, B. Prog. Lipid. Res. 1993, 32, 1-24.
http://dx.doi.org/10.1016/0163-7827(93)90002-E
[50]. Glasser, G.; Graefe, E. U.; Struck, F.; Veit, M.; Gebhardt, R. Phytomedicine 2002, 9, 33-40.
http://dx.doi.org/10.1078/0944-7113-00080
[51]. Lee, J. Y.; Park, H. R.; Moon, S. O.; Kwon, Y. J.; Rhee, S. J. Food Sci. Biotechnol. 2004, 2, 176-184.
[52]. Adluri, R. S.; Nagarajan, D.; Periyaswamy, V.; Venugopal, P. M. Fund. Clin. Pharmacol. 2008, 22, 557-567.
http://dx.doi.org/10.1111/j.1472-8206.2008.00622.x
[53]. Ceriello, A.; Quatraro, A.; Giugliano, D. Diabet. Med. 1992, 9, 297-299.
http://dx.doi.org/10.1111/j.1464-5491.1992.tb01783.x
[54]. Pietta, P. G. J. Nat. Prod. 2000, 63, 1035-1042.
http://dx.doi.org/10.1021/np9904509
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