

One-pot synthesis and antimicrobial activity of new 4,6-disubstituted-3,4-dihydropyrimidine-2(1H)-thiones
Mahmoud Al-Refai (1,*)




(1) Department of Chemistry, Faculty of Science, Al Al-Bayt University, Al-Mafraq, 25113, Jordan
(2) Department of Chemistry, Faculty of Science, Al Al-Bayt University, Al-Mafraq, 25113, Jordan
(3) Department of Biological Sciences, Faculty of Science, Al Al-Bayt University, Al-Mafraq, 25113, Jordan
(4) Faculty of Chemistry, Philipps University Marburg, Hans-Meerwein-Straße 4, Marburg, 35032, Germany
(*) Corresponding Author
Received: 12 Jan 2017 | Revised: 05 Feb 2017 | Accepted: 08 Feb 2017 | Published: 31 Mar 2017 | Issue Date: March 2017
Abstract
A series of 3,4-dihydropyrimidine-2(1H)-thiones (3a-i) were synthesized in moderate yields via a one-pot reaction of 3-acetyl-2,5-diclorothiophene (1), aryl aldehydes (2a-i) and thiourea in methanolic solution of potassium hydroxide under reflux conditions. All newly synthesized compounds were characterized by extensive NMR analysis, including 1D NMR experiments (1H and 13C) and 2D NMR experiments (COSY, HMBC and HSQC), as well as ESI-MS and HRESI-MS data. The antimicrobial activity of all new compounds (3a-f) was tested against bacteria and fungi. Thione derivative (3c) only showed activity against Staphylococcus aureus, Bacillus subtilis and Aspergillus niger.
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.8.1.96-100.1543
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Al Al-Bayt University (Mafraq, Jordan) and the DFG (Germany).
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DOI Link: https://doi.org/10.5155/eurjchem.8.1.96-100.1543

















European Journal of Chemistry 2017, 8(1), 96-100 | doi: https://doi.org/10.5155/eurjchem.8.1.96-100.1543 | Get rights and content
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