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Synthesis and antimicrobial activity of some novel N-substituted benzimidazoles
Dnyandev Radhu Gund (1)
, Alok Pramod Tripathi (2) , Sanjay Dashrath Vaidya (3,*) (1) Department of Chemistry, Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, 333001, India
(2) Department of Chemistry, Rajasthan University, Jaipur 302004, India
(3) Department of Chemistry, Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, 333001, India
(*) Corresponding Author
Received: 08 Mar 2017 | Revised: 08 Apr 2017 | Accepted: 09 Apr 2017 | Published: 30 Jun 2017 | Issue Date: June 2017
Abstract
Synthesis of a series of new substituted benzimidazole derivatives by the condensation of o-phenylenediamine with urea to give 1,3-dihydro-benzimidazol-2-one which reacted with phosphoryl chloride to give 2-chloro-1H-benzimidazole is reported. The product was then alkylated at the benzimidazole NH with different electrophilic reagents leading to functionalized derivatives. Structures of the newly synthesized products have been deduced on the basis of spectral and analytical data. The synthesized compounds were screened for their antimicrobial activity. This exhibited some promising results towards testing organism in-vitro.
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DOI: 10.5155/eurjchem.8.2.149-154.1563
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Sophisticated Analytical Instrumentation Facility, Punjab University and Microcare laboratories, Surat, India
Citations
[1]. Em Canh Pham, Tuong Vi Thi Le, Tuyen Ngoc Truong
Design, synthesis, bio-evaluation, and in silico studies of some N-substituted 6-(chloro/nitro)-1H-benzimidazole derivatives as antimicrobial and anticancer agents
RSC Advances 12(33), 21621, 2022
DOI: 10.1039/D2RA03491C
[2]. Em Canh Pham, Tuong Vi Le Thi, Huong Ha Ly Hong, Bich Ngoc Vo Thi, Long B. Vong, Thao Thanh Vu, Duy Duc Vo, Ngoc Vi Tran Nguyen, Khanh Nguyen Bao Le, Tuyen Ngoc Truong
N,2,6-Trisubstituted 1H-benzimidazole derivatives as a new scaffold of antimicrobial and anticancer agents: design, synthesis, in vitro evaluation, and in silico studies
RSC Advances 13(1), 399, 2023
DOI: 10.1039/D2RA06667J
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DOI Link: https://doi.org/10.5155/eurjchem.8.2.149-154.1563
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European Journal of Chemistry 2017, 8(2), 149-154 | doi: https://doi.org/10.5155/eurjchem.8.2.149-154.1563 | Get rights and content
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