European Journal of Chemistry 2017, 8(2), 149-154 | doi: https://doi.org/10.5155/eurjchem.8.2.149-154.1563 | Get rights and content

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Synthesis and antimicrobial activity of some novel N-substituted benzimidazoles


Dnyandev Radhu Gund (1) , Alok Pramod Tripathi (2) , Sanjay Dashrath Vaidya (3,*)

(1) Department of Chemistry, Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, 333001, India
(2) Department of Chemistry, Rajasthan University, Jaipur 302004, India
(3) Department of Chemistry, Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, 333001, India
(*) Corresponding Author

Received: 08 Mar 2017 | Revised: 08 Apr 2017 | Accepted: 09 Apr 2017 | Published: 30 Jun 2017 | Issue Date: June 2017

Abstract


Synthesis of a series of new substituted benzimidazole derivatives by the condensation of     o-phenylenediamine with urea to give 1,3-dihydro-benzimidazol-2-one which reacted with phosphoryl chloride to give 2-chloro-1H-benzimidazole is reported. The product was then alkylated at the benzimidazole NH with different electrophilic reagents leading to functionalized derivatives. Structures of the newly synthesized products have been deduced on the basis of spectral and analytical data. The synthesized compounds were screened for their antimicrobial activity. This exhibited some promising results towards testing organism in-vitro.


Keywords


Alkylation; Benzoylation; Benzimidazole; Antifungal activity; Antibacterial activity; Condensation reaction

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DOI: 10.5155/eurjchem.8.2.149-154.1563

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Funding information


Sophisticated Analytical Instrumentation Facility, Punjab University and Microcare laboratories, Surat, India

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How to cite


Gund, D.; Tripathi, A.; Vaidya, S. Eur. J. Chem. 2017, 8(2), 149-154. doi:10.5155/eurjchem.8.2.149-154.1563
Gund, D.; Tripathi, A.; Vaidya, S. Synthesis and antimicrobial activity of some novel N-substituted benzimidazoles. Eur. J. Chem. 2017, 8(2), 149-154. doi:10.5155/eurjchem.8.2.149-154.1563
Gund, D., Tripathi, A., & Vaidya, S. (2017). Synthesis and antimicrobial activity of some novel N-substituted benzimidazoles. European Journal of Chemistry, 8(2), 149-154. doi:10.5155/eurjchem.8.2.149-154.1563
Gund, Dnyandev, Alok Pramod Tripathi, & Sanjay Dashrath Vaidya. "Synthesis and antimicrobial activity of some novel N-substituted benzimidazoles." European Journal of Chemistry [Online], 8.2 (2017): 149-154. Web. 17 Oct. 2021
Gund, Dnyandev, Tripathi, Alok, AND Vaidya, Sanjay. "Synthesis and antimicrobial activity of some novel N-substituted benzimidazoles" European Journal of Chemistry [Online], Volume 8 Number 2 (30 June 2017)

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