European Journal of Chemistry 2015, 6(3), 270-274 | doi: | Get rights and content


Synthesis of some novel benzimidazole derivatives and their biological evaluation

Dnyandev Radhu Gund (1) , Balivada Venkata Satyasai Varaprasad Rao (2) , Pandurang Narayanrao Mandhare (3) , Sanjay Dashrath Vaidya (4,*)

(1) Department of Chemistry, Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, 333001, India
(2) Department of Chemistry, Pacific University, Udaipur, Rajasthan, 313024, India
(3) Department of Chemistry, Shreemati Nathibai Damodar Thackersey Women’s University, Mumbai, 400049, India
(4) Department of Chemistry, Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, 333001, India
(*) Corresponding Author

Received: 11 Jan 2015 | Revised: 05 Apr 2015 | Accepted: 05 Apr 2015 | Published: 30 Sep 2015 | Issue Date: September 2015


A series of novel benzimidazole derivatives have been synthesized by the condensation of o-phenylenediamine with 4-bromophenoxy acetic acid and product obtained was alkylated at the benzimidazole -NH with different electrophilic reagents. Subsequent reactions of the products by the Suzuki Coupling between benzimidazole derivatives and phenylboronic acid derivatives were accomplished. All these compounds were characterized by FT-IR, 1H NMR, MS and elemental analysis. These compounds were screened for their potential antibacterial and antifungal activities. This exhibited some promising results towards testing organism in-vitro.


Alkylation; Benzimidazole; Suzuki coupling; Antifungal activity; Phenyl boronic acid; Antibacterial activity

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DOI: 10.5155/eurjchem.6.3.270-274.1242

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Funding information

Analytical Instrumentation Facility, Punjab University, India



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How to cite

Gund, D.; Rao, B.; Mandhare, P.; Vaidya, S. Eur. J. Chem. 2015, 6(3), 270-274. doi:10.5155/eurjchem.6.3.270-274.1242
Gund, D.; Rao, B.; Mandhare, P.; Vaidya, S. Synthesis of some novel benzimidazole derivatives and their biological evaluation. Eur. J. Chem. 2015, 6(3), 270-274. doi:10.5155/eurjchem.6.3.270-274.1242
Gund, D., Rao, B., Mandhare, P., & Vaidya, S. (2015). Synthesis of some novel benzimidazole derivatives and their biological evaluation. European Journal of Chemistry, 6(3), 270-274. doi:10.5155/eurjchem.6.3.270-274.1242
Gund, Dnyandev, Balivada Venkata Satyasai Varaprasad Rao, Pandurang Narayanrao Mandhare, & Sanjay Dashrath Vaidya. "Synthesis of some novel benzimidazole derivatives and their biological evaluation." European Journal of Chemistry [Online], 6.3 (2015): 270-274. Web. 2 Jun. 2020
Gund, Dnyandev, Rao, Balivada, Mandhare, Pandurang, AND Vaidya, Sanjay. "Synthesis of some novel benzimidazole derivatives and their biological evaluation" European Journal of Chemistry [Online], Volume 6 Number 3 (30 September 2015)

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