OPEN ACCESS | PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS
A mathematical expression for tiemonium methylsulphate in its simultaneous spectrophotometric estimation with ketorolac tromethamine
Mohammad Nasir Uddin (1) , Md. Touhidul Kabir (2,*) , Monir Uddin (3)
(1) Department of Chemistry, University of Chittagong, Chittagong, 4331, Bangladesh
(2) Department of Chemistry, University of Chittagong, Chittagong, 4331, Bangladesh
(3) Department of Chemistry, University of Chittagong, Chittagong, 4331, Bangladesh
(*) Corresponding Author
Received: 14 Apr 2018 | Revised: 20 May 2018 | Accepted: 22 May 2018 | Published: 30 Jun 2018 | Issue Date: June 2018
Attempt has been made to develop a new, accurate, precise and economic spectrophotometric method for the simultaneous determination of ketorolactromethamine (KTR) and tiemoniummethylsulphate (TMS) in pharmaceutical formulation and bio-samples. It is noted that KTR shows two absorption peaks at 320 and 245 nm whereas TMS shows maximum absorption at 235 nm. In a mixture solution, peaks at 245 nm for KTR and at 235 nm for TMS are merged into a single peak at 240 nm. Hence KTR might be determined using its calibration equation constructed at 320 nm but the determination of TMS alone in their mixture measuring its absorption at 240 nm is difficult. Therefore, for the determination of TMS, a mathematical expression xT = k1.yK+T - k2.yK + k3 (y = Absorbance, x = Concentration) has been derived. This expression will give its concentration in mixture without having its absorption at 240 nm. Method has been applied to pharmaceutical and bio-samples successfully. Results have been compared to that estimated by new UPLC method developed as to validate this spectrophotometric method. The LOD and LOQ were found to be 0.25, 0.80 μg/mL for KTR and 0.31, 0.95 μg/mL for TMS, respectively.
Links for Article
| | | | |
| | | | | | |
Article MetricsThis Abstract was viewed 624 times | PDF Article downloaded 209 times
. Rang, H.; Dale, M.; Ritter, J.; Flower, R. Pharmacology, 6th Edition, Churchill Livingstone, Elsevier, 2007, 227-230
. Wang, Z.; Dsida, R.; Avram, M. J. Chromatog. B 2001, 755(1-2), 383-386.
. Shankar, C.; Mishra, M. Acta Pharm. 2003, 53, 101-110.
. Shyamala, B.; Sanmathi, B. S. Indian J. Pharm. Sci. 2001, 63, 538-540.
. Bejjani, A.; Nsouli, B.; Zahraman, K.; Assi, S.; Younes, G.; Yazbi, F. Adv. Mater. Res. 2011, 324, 318-323.
. Islam, M. S.; Wahiduzzaman, Islam, M. S.; Rafiquzzaman, M.; Kundu, S. K. Int. J Pharm Sci. Res. 2014, 5(2), 548-55.
. Ayad, M.; El-Balkiny, M.; Hosny, M.; Metias, Y. Indian J. Advances Chem. Sci. 2016, 4(1), 85-97.
. Zaaza, H. E.; Abbas, S. S.; El-Sherif, Z. A.; El-Zeany, B.; El-Haddad, D. A. J. App. Pharm. Sci. 2014, 4(1), 33-45.
. Ramadan, N. K.; Abd El Halim, L. M.; El-Sanabary, H. F. A.; Salem, M. Y. Int. J. Drug Dev. Res. 2014, 6(1), 160-168.
. Ramadan, N. K.; El-Halim, L. M. A.; El-Sanabary, H. F. A.; Salem, M. Y. Int. J. Advanced Res. 2014, 2(1), 366-376.
. Chaudhary, R.; Gangwal, S.; Jindal, K.; Khann, a S. J. Chromatog. B 1993, 614(1), 180-184.
. Uddin, M. N.; Das, S.; Khan, S. H.; Shill, S. K.; Bhuiyan, H. R.; Karim, R. Research 2014, 1, 1237-1245.
. Logan, B.; Friel, N. P.; Peterson, K. L.; Predmore, B. B. J. Anal. Toxicol. 1995, 19, 61-64.
. Ayad, M.; El-Balkiny, M.; Hosny, M.; Metias, Y. Innovare J. Medical Sci. 2016, 4(3), 1-9.
. Uddin, M. N.; Uddin, M.; Kabir, M. T.; Das, S. J. Pure App. Chem. Res. 2017, 6(2), 137-149.
. Uddin, M. N.; Uddin, M.; Kabir, M. T. Indonesian J. Pharm. Sci. Tech. 2018, 5(1), 15-25.
. Uddin, M. N.; Uddin, M.; Kabir, M. T.; Das, S. Pharm. Pharmacol. Int. J. 2017, 5(2), 117-124.
. ICH Harmonized Tripartite (1996) Validation of Analytical Procedures: Text and Methodology Q2 (R1), Current Step 4 Version, Parent Guidelines on Methodology Dated November 6 1996, Incorporated In: International Conference on Harmonization, Geneva, Switzerland, 2005.
How to cite
DOI Link: https://doi.org/10.5155/eurjchem.9.2.138-146.1715
| | | | |
| | | | | |
Save to Zotero Save to Mendeley
European Journal of Chemistry 2018, 9(2), 138-146 | doi: https://doi.org/10.5155/eurjchem.9.2.138-146.1715 | Get rights and content
- There are currently no refbacks.
Copyright (c) 2018 Authors
This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at http://www.eurjchem.com/index.php/eurjchem/pages/view/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (http://www.eurjchem.com/index.php/eurjchem/pages/view/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).
© Copyright 2019 • Atlanta Publishing House LLC • All Right Reserved.
The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.
Copyright 2019 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 4614 Lavista road, Tucker, GA, 30084, USA. Registered in USA.