European Journal of Chemistry

A mild and efficient method for the deprotection of trimethyl silyl alkynes using sodium ascorbate and copper sulphate

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Published: Dec 31, 2018
DOI: https://doi.org/10.5155/eurjchem.9.4.317-321.1729
Keywords:
Deprotection, Ethanol-water, Copper sulphate, Protecting group, Sodium ascorbate, Trimethyl silyl alkyne
Section
Research Article
Issue
Vol. 9 No. 4 (2018): December 2018
Dates
Received 2018-05-03
Accepted 2018-05-19
Published 2018-12-31
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Ranjith Siddaraj
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006, Karnataka, India
http://orcid.org/0000-0002-4780-9144
Raghu Ningegowda
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006, Karnataka, India
http://orcid.org/0000-0003-4817-4061
Nanjunda Swamy Shivananju
Department of Biotechnology, Sri Jayachamarajendra College of Engineering, JSS Technical Institutions Campus, Mysore 570006, Karnataka, India
http://orcid.org/0000-0002-5494-9428
Babu Shubha Priya
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006, Karnataka, India
http://orcid.org/0000-0003-1110-0771

Abstract

A competent and fast method for the deprotection of trimethyl silyl group was attained by using cheap, easily accessible, and nontoxic sodium ascorbate in combination with copper sulphate. The method labored was simple and effective for the cleavage of trimethyl silyl group from the protected trimethyl silyl alkynes to their corresponding alkyne derivatives. Wide functional group tolerance, shorter time period, simple procedure and high yields are the striking features of this protocol.


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Siddaraj, R.; Ningegowda, R.; Shivananju, N. S.; Priya, B. S. A Mild and Efficient Method for the Deprotection of Trimethyl Silyl Alkynes Using Sodium Ascorbate and Copper Sulphate. Eur. J. Chem. 2018, 9, 317-321.

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