OPEN ACCESS | PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS
Synthesis and antimicrobial activity of some new pyrazoline derivatives bearing sulfanilamido moiety
Maysoon Mohammed Almahdi (1,*) , Ahmed Elsadig Mohammed Saeed (2) , Nadia Hanafy Metwally (3)
(1) Department of Chemistry, College of Education, Alzaiem Alazhari University, 1432, Khartoum, Sudan
(2) Department of Chemistry, College of Science, Sudan University of Science and Technology, 407, Khartoum, Sudan
(3) Department of Chemistry, Faculty of Science, Cairo University, 12613, Giza, Egypt
(*) Corresponding Author
Received: 27 Sep 2018 | Revised: 04 Nov 2018 | Accepted: 08 Nov 2018 | Published: 31 Mar 2019 | Issue Date: March 2019
In the present study, a series of new pyrazoline derivatives bearing sulfanilamido moiety were synthesized and obtained in good yields. The chemical structures of the compounds were elucidated by spectral data (FT-IR, MS, UV-VIS and NMR). The synthesized compounds 41-70 were screened for their antimicrobial activity and compared with controls. The in vitro antibacterial activity of compounds 41-45 and 48-57 was checked against two Gram positive microorganisms (S. aureus and S. mutans) and three Gram negative microorganisms (E. coli, K. pneumonia and P. aureginosa), their antifungal activity was checked against C. albicans. The preliminary results showed that these compounds had moderate activity against the tested organisms. Compounds 41, 48, 51 and 56 exhibited promising antimicrobial activity against S. aureus compared to standard drug Ampicilin. Final synthesized compounds 58-70 were tested against two Gram positive (S. aureus and B. subtilis) and two Gram negative (E. coli and P. aureginosa) microorganisms, their activity against C. albicans was also checked and they did not exhibit any antimicrobial activity.
Links for Article
| | | | | | |
| | | | | | |
| | |
Article MetricsThis Abstract was viewed 1750 times | PDF Article downloaded 531 times
. Mohammad Asad, Muhammad Nadeem Arshad, Mohammad Oves, Muhammad Khalid, Salman A. Khan, Abdullah M. Asiri, Mohd Rehan, Hurija Dzudzevic-Cancar
N-Trifluoroacetylated pyrazolines: Synthesis, characterization and antimicrobial studies
Bioorganic Chemistry 99, 103842, 2020
. Mohammad Asad, Muhammad Nadeem Arshad, Salman A. Khan, Mohammad Oves, Muhammad Khalid, Abdullah M. Asiri, Ataualpa A.C. Braga
Cyclization of chalcones into N-propionyl pyrazolines for their single crystal X-ray, computational and antibacterial studies
Journal of Molecular Structure 1201, 127186, 2020
. Ioanna Kostopoulou, Antonia Diassakou, Eleni Kavetsou, Eftichia Kritsi, Panagiotis Zoumpoulakis, Eleni Pontiki, Dimitra Hadjipavlou-Litina, Anastasia Detsi
Novel quinolinone–pyrazoline hybrids: synthesis and evaluation of antioxidant and lipoxygenase inhibitory activity
Molecular Diversity , , 2020
. Anjaly Das, Aparna Das, Bimal Krishna Banik
Influence of Dipole Moments on the Medicinal Activities of Diverse Organic Compounds
Journal of the Indian Chemical Society , 100005, 2021
. Shehneela Nisa, Mohamad Yusuf
Synthesis, Characterization & Antimicrobial Evaluation of New bis(5-Biphenyl-3-alkoxyphenyl-4,5-dihydro-1H-pyrazole-N-carbothioamide) Derivatives
Asian Journal of Organic & Medicinal Chemistry 5(1), 77, 2020
. Maria Chatzidaki, Ioanna Kostopoulou, Chryssa Kourtesi, Ioanna Pitterou, Spyridon Avramiotis, Aristotelis Xenakis, Anastasia Detsi
β-Cyclodextrin as carrier of novel antioxidants: A structural and efficacy study
Colloids and Surfaces A: Physicochemical and Engineering Aspects 603, 125262, 2020
. Yusuf, M.; Jain, P. Arab. J. Chem. 2014, 7, 553-596.
. Rani, M.; Yusuf, M. Eur. J. Chem. 2012, 3(4), 406‐410.
. Gokhan-Kelekci, N.; Koyunoglu, S.; Yabanoglu, S.; Yelekci, K.; Ozgen, O.; Ucar, G.; Erol, K.; Kendi, E.; Yesilada, A. Bioorg. Med. Chem. 2009, 17, 675-689.
. Shinkar, S. A.; Shetty, V. J.; Jagdale, D. M. World J. Pharm. Pharm. Sci. 2015, 4, 505-514.
. Shah, S.; Ziauddin, H. M.; Zameer, M.; Khan, T.; Baseer, M. A. Int. J. Curr. Pharm. Res. 2011, 2, 34-36.
. Karabacak, M.; Altıntop, M. D.; Ciftci, H. I.; Koga, R.; Otsuka, M.; Fujita, M.; Ozdemir, A. Molecules 2015, 20, 19066-19084.
. Kumar, K. A.; Govindaraju, M. Int. J. Chem. Tech. Res. 2015, 8, 313-322.
. Ziani, N.; Lamara, K.; Sid, A.; Willem, Q.; Dassonneville, B.; Demonceau, A. Eur. J. Chem. 2013, 4(2), 176‐179.
. Rahman, Md. A.; Siddiqui, A. A.; Int. J. Pharm. Sci. Drug Res. 2010, 2, 165-175.
. Khan, S. A.; Asiri, A. M.; Kumar, S.; Sharma, K. Eur. J. Chem. 2014, 5(1), 85‐90.
. Mahdi, M. F.; Raauf, A. M. R.; Mohammed, N. M. Eur. J. Chem. 2015, 6(4), 461‐467.
How to cite
The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item
DOI Link: https://doi.org/10.5155/eurjchem.10.1.30-36.1791
| | | | | | | | |
| | | | | |
Save to Zotero Save to Mendeley
European Journal of Chemistry 2019, 10(1), 30-36 | doi: https://doi.org/10.5155/eurjchem.10.1.30-36.1791 | Get rights and content
- There are currently no refbacks.
Copyright (c) 2019 Authors
This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at http://www.eurjchem.com/index.php/eurjchem/pages/view/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (http://www.eurjchem.com/index.php/eurjchem/pages/view/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).
© Copyright 2010 - 2021 • Atlanta Publishing House LLC • All Right Reserved.
The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.
Copyright 2010-2021 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.