Email this article 
Hide
Show all
OPEN ACCESS | 
PEER-REVIEWED |
RESEARCH ARTICLE
|
DOWNLOAD PDF
|
VIEW FULL-TEXT PDF
| TOTAL VIEWS
Spectrophotometric method for determination of ranitidine hydrochloride in bulk and in pharmaceutical preparation using ninhydrin
Hutaf Mustafa Baker (1,*)
, Hussam Ahmad Alsaoud (2) , Hamzeh Mohamad Abdel-Halim (3) (1) Department of Chemistry, Faculty of Science, Al Al‐Bayt University, Mafraq, 25113, Jordan
(2) Department of Chemistry, Faculty of Science, Al Al‐Bayt University, Mafraq, 25113, Jordan
(3) Department of Chemistry, Hashemite University, P.O. Box 150459, Zarqa, 13115, Jordan
(*) Corresponding Author
Received: 01 Jul 2020 | Revised: 21 Sep 2020 | Accepted: 26 Sep 2020 | Published: 31 Dec 2020 | Issue Date: December 2020
Abstract
A simple, sensitive and reproducible method for the determination of ranitidine hydrochloride in pharmaceutical preparations was investigated. This spectrophotometric method was based on the formation of a deep red color product with ninhydrin in basic media and the absorbance measured at λmax = 480 nm. The reaction occurs at 45 °C with pH = 10 having a contact time of 38 minutes. Under the optimum conditions, Beer’s Law is obeyed in the concentration range of 8.98×103 - 9.90×104 µg/L. The coefficient of correlation was found to be 0.999 for the obtained method with molar absorptivity of 3.05×103 L/mol.cm. The calculated Sandell’s sensitivity is 0.108 μg/cm2. The limit of detection and limit of quantification are 0.0997 and 0.3023 µg/mL, respectively. The low values of the percentage relative standard deviation and percentage relative error indicate the high precision and the good accuracy of the proposed method. The stoichiometry of the reaction is determined and found to be 1:4 (Ranitidine hydrochloride:Ninhydrin). The initial rate method confirmed that this reaction is first order one.
Announcements
Our editors have decided to support scientists to publish their manuscripts in European Journal of Chemistry without any financial constraints.
1- The article processing fee will not be charged from the articles containing the single-crystal structure characterization between July 1, 2022 and August 15, 2022 (Voucher code: SINGLE2022).
2. Young writers will not be charged for the article processing fee between July 1, 2022 and August 15, 2022 (Voucher code: YOUNG2022).
3. The article processing fee will not be charged from the articles containing a part of the PhD thesis between July 1, 2022 and August 15, 2022 (Voucher code: PhD2022).
Editor-in-Chief
European Journal of Chemistry
Keywords
Full Text:
PDF
DOI: 10.5155/eurjchem.11.4.291-297.2002
Links for Article
| | | | | | |
| | | | | | |
| | | |
Related Articles
Article Metrics
This Abstract was viewed 603 times |
PDF Article downloaded 221 times
Funding information
Al Al‐Bayt University, Mafraq, Jordan.
References
[1]. Basavaiah, K.; Nagegowda, P. Il Farmaco 2004, 59, 147-153.
https://doi.org/10.1016/j.farmac.2003.11.012
[2]. Narayana, B.; Ashwini, K. Eurasian J. Anal. Chem. 2010, 5(2), 170-176.
[3]. Walash, M. I.; Sharaf-El-Din, M. K.; Metwally, M. E.; Shabana, M. R. J. Chinese Chem. Soc. 2004, 51, 523-530.
https://doi.org/10.1002/jccs.200400079
[4]. Ozden, T.; Ungormus, A.; Tosun, A.; Ersan, S. Spectr. Lett. 1997, 30(5), 835-841.
https://doi.org/10.1080/00387019708001632
[5]. Dreassi, E.; Ceramelli, G.; Corti, P.; Perruccio, P. L.; Lonardi, S. Analyst 1996, 121(2), 219-222.
https://doi.org/10.1039/an9962100219
[6]. Lopez-Erroz, C.; Vinas, P.; Campillo, N.; Hernandez-Cordoba, M. Analyst 1996, 121(8), 1043-1046.
https://doi.org/10.1039/AN9962101043
[7]. Issa, M.; Badawy, S.; Mutair, A. Anal. Sci. 2005, 21, 1443-1448.
https://doi.org/10.2116/analsci.21.1443
[8]. Norouzi, P.; Ganjali, R.; Daneshgar, P. J. Pharmacol. Toxicol. Methods 2007, 55, 289-296.
https://doi.org/10.1016/j.vascn.2006.09.001
[9]. Sankar, P. S.; Reddy, S. J. Indian J. Pharmaceut. Sci. 1989, 51, 263-264.
[10]. Li, X.; Xu, G. J. Food Drug Anal. 2014, 22, 345-349.
https://doi.org/10.1016/j.jfda.2013.09.050
[11]. Gao, Y.; Tian, Y.; Sun, X.; Yin, X.; Xiang, Q.; Ma, G.; Wang, E. J. Chromatog. B 2006, 832, 236-240.
https://doi.org/10.1016/j.jchromb.2006.01.004
[12]. Basavaiah, K.; Somashekar, B. C. J. Iranian Chem. Soc. 2007, 4(1), 78-88.
https://doi.org/10.1007/BF03245806
[13]. Singare, P. Res. J. Pharmaceut. Bio. Chem. Sci. 2016, 7(5), 1949-1961.
[14]. Majidano, S.; Khuhawar, M. Chromatographia 2012, 75, 1311-1317.
https://doi.org/10.1007/s10337-012-2321-6
[15]. Ulu, S. T.; Tuncel, M. J. Chromatog. Sci. 2012, 50, 301-306.
https://doi.org/10.1093/chromsci/bms003
[16]. Haque, M.; Shahriar, M.; Parvin, M.; Ashraful, I. S. Asian J. Pharm. Anal. 2011, 1(3), 59-63.
[17]. Al‐Tamimi, S. A.; Aly, F. A.; Almutairi, A. M. J. Anal. Chem. 2013, 68(4), 313‐320.
https://doi.org/10.1134/S1061934813040102
[18]. Baker, M. H.; Alzboon, F. K. Eur. J. Chem. 2015, 6(2), 135‐140.
https://doi.org/10.5155/eurjchem.6.2.135-140.1178
[19]. Narayana, B.; Ashwini, K.; Narayana, S. D.; Veena, K. Eurasian J. Anal. Chem. 2010, 5(1), 63-72.
[20]. Ozkan, S. A.; Uslu, B. J. Liquid Chromatog. Rel. Tech. 2002, 25(9), 1447-1456.
https://doi.org/10.1081/JLC-120004759
[21]. El-Enany, N.; Belal, F.; Rizk, M. Il Farmaco 2002, 57, 641-648.
https://doi.org/10.1016/S0014-827X(02)01236-3
How to cite
The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item
DOI Link: https://doi.org/10.5155/eurjchem.11.4.291-297.2002
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
Save to Zotero
Save to Mendeley
European Journal of Chemistry 2020, 11(4), 291-297 | doi: https://doi.org/10.5155/eurjchem.11.4.291-297.2002 | Get rights and content
Refbacks
- There are currently no refbacks.
Copyright (c) 2020 Authors
This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at http://www.eurjchem.com/index.php/eurjchem/pages/view/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (http://www.eurjchem.com/index.php/eurjchem/pages/view/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).
© Copyright 2010 - 2022 • Atlanta Publishing House LLC • All Right Reserved.
The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.
Copyright 2010-2022 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.