European Journal of Chemistry 2020, 11(4), 291-297 | doi: https://doi.org/10.5155/eurjchem.11.4.291-297.2002 | Get rights and content

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Spectrophotometric method for determination of ranitidine hydrochloride in bulk and in pharmaceutical preparation using ninhydrin


Hutaf Mustafa Baker (1,*) orcid , Hussam Ahmad Alsaoud (2) orcid , Hamzeh Mohamad Abdel-Halim (3) orcid

(1) Department of Chemistry, Faculty of Science, Al Al‐Bayt University, Mafraq, 25113, Jordan
(2) Department of Chemistry, Faculty of Science, Al Al‐Bayt University, Mafraq, 25113, Jordan
(3) Department of Chemistry, Hashemite University, P.O. Box 150459, Zarqa, 13115, Jordan
(*) Corresponding Author

Received: 01 Jul 2020 | Revised: 21 Sep 2020 | Accepted: 26 Sep 2020 | Published: 31 Dec 2020 | Issue Date: December 2020

Abstract


A simple, sensitive and reproducible method for the determination of ranitidine hydrochloride in pharmaceutical preparations was investigated. This spectrophotometric method was based on the formation of a deep red color product with ninhydrin in basic media and the absorbance measured at λmax = 480 nm. The reaction occurs at 45 °C with pH = 10 having a contact time of 38 minutes. Under the optimum conditions, Beer’s Law is obeyed in the concentration range of 8.98×103 - 9.90×104 µg/L. The coefficient of correlation was found to be 0.999 for the obtained method with molar absorptivity of 3.05×103 L/mol.cm. The calculated Sandell’s sensitivity is 0.108 μg/cm2. The limit of detection and limit of quantification are 0.0997 and 0.3023 µg/mL, respectively. The low values of the percentage relative standard deviation and percentage relative error indicate the high precision and the good accuracy of the proposed method. The stoichiometry of the reaction is determined and found to be 1:4 (Ranitidine hydrochloride:Ninhydrin). The initial rate method confirmed that this reaction is first order one.


Keywords


Kinetics; Ninhydrin; Validation; Stoichiometry; Calibration curve; Ranitidine hydrochloride

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DOI: 10.5155/eurjchem.11.4.291-297.2002

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Funding information


Al Al‐Bayt University, Mafraq, Jordan.

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How to cite


Baker, H.; Alsaoud, H.; Abdel-Halim, H. Eur. J. Chem. 2020, 11(4), 291-297. doi:10.5155/eurjchem.11.4.291-297.2002
Baker, H.; Alsaoud, H.; Abdel-Halim, H. Spectrophotometric method for determination of ranitidine hydrochloride in bulk and in pharmaceutical preparation using ninhydrin. Eur. J. Chem. 2020, 11(4), 291-297. doi:10.5155/eurjchem.11.4.291-297.2002
Baker, H., Alsaoud, H., & Abdel-Halim, H. (2020). Spectrophotometric method for determination of ranitidine hydrochloride in bulk and in pharmaceutical preparation using ninhydrin. European Journal of Chemistry, 11(4), 291-297. doi:10.5155/eurjchem.11.4.291-297.2002
Baker, Hutaf, Hussam Ahmad Alsaoud, & Hamzeh Mohamad Abdel-Halim. "Spectrophotometric method for determination of ranitidine hydrochloride in bulk and in pharmaceutical preparation using ninhydrin." European Journal of Chemistry [Online], 11.4 (2020): 291-297. Web. 12 Apr. 2021
Baker, Hutaf, Alsaoud, Hussam, AND Abdel-Halim, Hamzeh. "Spectrophotometric method for determination of ranitidine hydrochloride in bulk and in pharmaceutical preparation using ninhydrin" European Journal of Chemistry [Online], Volume 11 Number 4 (31 December 2020)

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