European Journal of Chemistry

Synthesis, computational studies, and Hirshfeld surface analysis of 2H-chromen-2-one and imine derivatives

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Published: Jun 30, 2023
DOI: https://doi.org/10.5155/eurjchem.14.2.287-296.2389
Keywords:
Imine, Crystal, Coumarin, Monoclinic, Chemical reactivity, Hirshfeld surface analysis
Section
Research Article
Issue
Vol. 14 No. 2 (2023): June 2023
Dates
Received 2022-12-18
Accepted 2023-01-19
Published 2023-06-30
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Felix Odame
Department of Basic Sciences, School of Basics and Biomedical Sciences, University of Health and Allied Sciences, PMB 31, Ho, Ghana
https://orcid.org/0000-0001-7651-8816
Tatenda Madanhire
Department of Chemistry, Nelson Mandela University, PO Box 77000, Gqeberha 6000, South Africa
https://orcid.org/0000-0001-6352-183X
Jerry Joe Ebo Kingsley Harrison
Department of Chemistry, University of Ghana, PO Box LG 56, Legon, Accra, Ghana
https://orcid.org/0000-0002-3153-3024
Nathaniel Owusu Boadi
Department of Chemistry, Kwame Nkrumah University of Science and Technology, Kumasi, University Post Office, Kumasi, Ghana
https://orcid.org/0000-0003-2673-7011
Eric Hosten
Department of Chemistry, Nelson Mandela University, PO Box 77000, Gqeberha 6000, South Africa
https://orcid.org/0000-0003-4173-2550

Abstract

Some 2H-chromen-2-one and imine derivatives have been synthesized through a one-pot condensation of aldehydes, diethyl malonate, and amine compounds. The compounds obtained have been characterized using FTIR, NMR, GC-MS, and elemental analysis. The single-crystal X-ray structure of 3-[piperidine-1-carbonyl]-2H-chromen-2-one (2) has been presented. Compound 2, recrystallized in the monoclinic space C2/c (no. 15), a = 16.654(15) Å, b = 8.789(7) Å, c = 18.460(18) Å, β = 102.89(5)°, V = 2634(4) Å3, Z = 8, T = 296(2) K, μ(MoKα) = 0.091 mm-1, Dcalc = 1.298 g/cm3, 17626 reflections measured (4.528° ≤ 2Θ ≤ 57.446°), 3321 unique (Rint = 0.0313, Rsigma = 0.0257) which were used in all calculations. The final R1 was 0.0441 (I > 2σ(I)) and wR2 was 0.1329 (all data). The experimental bond lengths, bond angles, and other topological properties of compound 2 were compared with the DFT calculated results, the comparison showed good agreement with each other with varying level deviations. The energy levels of HOMO and LUMO, as well as the global chemical reactivity descriptors of representative compound 2, have been presented. A discussion of the Hirshfeld surface analysis of compound 2 has been carried out to provide insight into its structural properties.


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Odame, F.; Madanhire, T.; Harrison, J. J. E. K.; Boadi, N. O.; Hosten, E. Synthesis, Computational Studies, and Hirshfeld Surface Analysis of 2H-Chromen-2-One and Imine Derivatives. Eur. J. Chem. 2023, 14, 287-296.

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