Magnetically recoverable nanocatalyst for the synthesis of pyranopyrazoles: CoFe2O4@SiO2-HClO4

Nikita Vinod Thakare; Anand Shankar Aswar; Nilesh Govindrao Salunkhe

doi:10.5155/eurjchem.14.3.385-392.2457

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Published: Sep 30, 2023

DOI: https://doi.org/10.5155/eurjchem.14.3.385-392.2457

Keywords:

Solvent-free, Pyranopyrazoles, Microbial activity, Microwave-assisted, Multicomponent reaction, Magnetically recoverable catalyst

Section

Research Article

Issue

Vol. 14 No. 3 (2023): September 2023

Dates

Received 2023-05-30
Accepted 2023-06-24
Published 2023-09-30

Nikita Vinod Thakare

Department of Chemistry, Elphinstone College, Homi Bhabha State University, Mumbai, 400032, India

https://orcid.org/0009-0005-9583-110X

Anand Shankar Aswar

Department of Chemistry, Sant Gadge Baba Amravati University, Amravati, 444602, India

https://orcid.org/0000-0003-4368-496X

Nilesh Govindrao Salunkhe

Department of Chemistry, Sant Gadge Baba Amravati University, Amravati, 444602, India

https://orcid.org/0000-0001-7897-2721

Abstract

The multiheterocyclic ring system shows valuable pharmaceutical and biological activities. In the present study, a microwave-assisted three-component reaction between aryl aldehyde, malononitrile, and 5-methyl-2,4-dihydro-3H-pyrazole-3-one led to the synthesis of pyrano[2,3-c]pyrazoles has been described. The reaction was carried out under solvent-free conditions in the presence of a new magnetically recoverable nanocatalyst (CoFe₂O₄@SiO₂-HClO₄). The reported protocol offers several advantages such as being environmentally benign, being rapid, inexpensive, having high atom and step economy, and being facile. The simple method of catalyst preparation, easy magnetic recovery, and reusability of the catalyst for four runs are notable features of the nanocatalyst. Antibacterial activity of all synthesized compounds was tested against Escherichia coli and Staphylococcus aureus. All synthesized compounds showed promising biological activity and may be used as a potential antibacterial candidate in biological science.

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Thakare, N. V.; Aswar, A. S.; Salunkhe, N. G. Magnetically Recoverable Nanocatalyst for the Synthesis of Pyranopyrazoles: CoFe2O4@SiO2-HClO4. Eur. J. Chem. 2023, 14, 385-392.

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