European Journal of Chemistry 2014, 5(1), 122-126. doi:10.5155/eurjchem.5.1.122-126.911

A microwave-assisted synthesis of 3,4-dihydropyrimidin-2(1H)-one/thione derivatives using nanocrystalline MgFe2O4 as catalyst


Chandrashekhar Arunrao Ladole (1) , Nilesh Govindrao Salunkhe (2) , Ravindra Sakharam Bhaskar (3) , Anand Shankarrao Aswar (4,*)

(1) Department of Chemistry, Sant Gadge Baba Amravati University, Amravati, 444602, India
(2) Department of Chemistry, Sant Gadge Baba Amravati University, Amravati, 444602, India
(3) Department of Chemistry, Sant Gadge Baba Amravati University, Amravati, 444602, India
(4) Department of Chemistry, Sant Gadge Baba Amravati University, Amravati, 444602, India
(*) Corresponding Author

Received: 27 Aug 2013, Accepted: 13 Oct 2013, Published: 31 Mar 2014

Abstract


3,4-Dihydropyrimidin-2(1H)-one/thione derivatives were synthesized in moderate to high yields via one-pot three component Biginelli reaction of aldehydes, ethyl acetoacetate and urea/thiourea in the presence of nanocrystalline MgFe2O4 as an efficient catalyst, in microwave irradiation under solvent free condition. This protocol offers several advantages including good yields of products, short reaction time and easy work-up procedure.

Keywords


Catalyst; Biginelli reaction; Microwave technique; Nanocrystalline MgFe2O4; 3,4-Dihydropyrimidinones; 3,4-Dihydropyrimidine thiones

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DOI: 10.5155/eurjchem.5.1.122-126.911

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[1]. Amr M. Abdou, S. Botros, Rasha A. Hassan, Mona M. Kamel, Douglass F. Taber, Azza T. Taher
Useful four-carbon synthons en route to monastrol analogs
Tetrahedron  71(1), 139, 2015
DOI: 10.1016/j.tet.2014.11.022
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How to cite


Ladole, C.; Salunkhe, N.; Bhaskar, R.; Aswar, A. Eur. J. Chem. 2014, 5(1), 122-126. doi:10.5155/eurjchem.5.1.122-126.911
Ladole, C.; Salunkhe, N.; Bhaskar, R.; Aswar, A. A microwave-assisted synthesis of 3,4-dihydropyrimidin-2(1H)-one/thione derivatives using nanocrystalline MgFe2O4 as catalyst. Eur. J. Chem. 2014, 5(1), 122-126. doi:10.5155/eurjchem.5.1.122-126.911
Ladole, C., Salunkhe, N., Bhaskar, R., & Aswar, A. (2014). A microwave-assisted synthesis of 3,4-dihydropyrimidin-2(1H)-one/thione derivatives using nanocrystalline MgFe2O4 as catalyst. European Journal of Chemistry, 5(1), 122-126. doi:10.5155/eurjchem.5.1.122-126.911
Ladole, Chandrashekhar, Nilesh Govindrao Salunkhe, Ravindra Sakharam Bhaskar, & Anand Shankarrao Aswar. "A microwave-assisted synthesis of 3,4-dihydropyrimidin-2(1H)-one/thione derivatives using nanocrystalline MgFe2O4 as catalyst." European Journal of Chemistry [Online], 5.1 (2014): 122-126. Web. 16 Sep. 2019
Ladole, Chandrashekhar, Salunkhe, Nilesh, Bhaskar, Ravindra, AND Aswar, Anand. "A microwave-assisted synthesis of 3,4-dihydropyrimidin-2(1H)-one/thione derivatives using nanocrystalline MgFe2O4 as catalyst" European Journal of Chemistry [Online], Volume 5 Number 1 (31 March 2014)

DOI Link: https://doi.org/10.5155/eurjchem.5.1.122-126.911

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