Efficient synthesis of azoxystrobin and its key intermediate using a newer DABCO-based catalyst

Nilesh Dattatraya Dhande; Tushar Tulsidas Pansare; Uday Vasudev Baviskar; Hemant Prabhakar Narkhede

doi:10.5155/eurjchem.17.1.19-25.2739

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Published: Mar 31, 2026

DOI: https://doi.org/10.5155/eurjchem.17.1.19-25.2739

Keywords:

Fungicide, Azoxystrobin, Organocatalysis, Yield improvement, DABCO-based catalyst, Synthetic methodology

Section

Research Article

Issue

Vol. 17 No. 1 (2026): March 2026

Dates

Received 2025-12-10
Accepted 2026-02-13
Published 2026-03-31

Nilesh Dattatraya Dhande

Department of Chemistry, Dadasaheb Devidas Namdeo Bhole College, Bhusawal, Dist.- Jalgaon, Maharashtra 425 201, India

https://orcid.org/0009-0007-8225-917X

Tushar Tulsidas Pansare

Department of Chemistry, Smt. Padamabai Kapurchandji Kotecha Mahila Mahavidyalaya, Bhusawal, District-Jalgaon, Maharashtra-425 201, India

https://orcid.org/0009-0006-3448-1908

Uday Vasudev Baviskar

Department of Chemistry, Khopoli Municipal Council College, Khopoli, Dist.-Raigad, Maharashtra-410 203, India

https://orcid.org/0009-0004-2506-9933

Hemant Prabhakar Narkhede

Department of Chemistry, Smt. Padamabai Kapurchandji Kotecha Mahila Mahavidyalaya, Bhusawal, District-Jalgaon, Maharashtra-425 201, India

https://orcid.org/0000-0002-8382-4691

Abstract

A simple, convenient, and commercially feasible synthesis method has been developed for the synthesis of azoxystrobin and its intermediate using a DABCO-based catalyst. The methodology, which starts with coumaranone, uses a single catalyst for the two-step process, demonstrating high potential for industrial application. The catalyst synthesis and optimal catalyst concentration have been optimized to achieve maximum yield in the synthesis of the intermediate as well as technical azoxystrobin. The intermediate and final products, as well as the catalyst, were characterized by melting point, ¹H NMR, ¹³C NMR, and high-resolution mass spectrometry. The HRMS analysis data supported the molecular formulae of the synthesized catalyst and product, showing the fragments m/z 143.1188 (M+H), C₇H₁₄N_2O and 404.1262 (M+H), C₂₂H₁₇N₃O₅. The newer catalyst has the merits of being inexpensive, highly reactive, and environmentally friendly. The yield reached a high level, and this method can be considered a promising catalyst for the industrial-scale production of azoxystrobin and its key intermediate.

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Dhande, N. D.; Pansare, T. T.; Baviskar, U. V.; Narkhede, H. P. Efficient Synthesis of Azoxystrobin and Its Key Intermediate Using a Newer DABCO-Based Catalyst. Eur. J. Chem. 2026, 17, 19-25.

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Supporting Agencies

Smt. Padamabai Kapurchandji Kotecha Mahila Mahavidyalaya, Bhusawal, District-Jalgaon, Maharashtra-425 201, India, Dadasaheb Devidas Namdeo Bhole College, Bhusawal, Dist.- Jalgaon, Maharashtra 425 201, India.

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