European Journal of Chemistry 2011, 2(3), 295-299 | doi: https://doi.org/10.5155/eurjchem.2.3.295-299.376 | Get rights and content

Issue cover





  Open Access OPEN ACCESS | Open Access PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS

Synthesis of nitrogen heterocycles from ethyl 3-(6-dibenzothiophen-2-yl-pyridazin-3-ylamino)-3-oxopropanoate


Mohamed Sayed Behalo (1,*) , Aly Abdelmaboud Aly (2)

(1) Department of Chemistry, Faculty of Science, Benha University, Benha, 13518, Egypt
(2) Department of Chemistry, Faculty of Science, Benha University, Benha, 13518, Egypt
(*) Corresponding Author

Received: 24 Dec 2010 | Revised: 30 Apr 2011 | Accepted: 29 Mar 2011 | Published: 30 Sep 2011 | Issue Date: September 2011

Abstract


An efficient synthesis of nitrogen-containing heterocycles pyrazole, triazole,  pyridinone and pyrimidinone derivatives from ethyl 3-(6-dibenzothiophen-2-yl-pyridazin-3-ylamino)-3-oxopropanoate (2) was described. The structures of all products were confirmed and characterized by the elemental analysis and spectroscopic studies (IR, MS, 1H NMR, 13C NMR).

2_3_295_299_800


Keywords


Dibenzothiophene; Pyridazine; Triazole; Pyrimidinone; Pyrazole; Pyridinone

Full Text:

PDF
PDF    Open Access

DOI: 10.5155/eurjchem.2.3.295-299.376

Links for Article


| | | | | | |

| | | | | | |

| | |

Related Articles




Article Metrics

icon graph This Abstract was viewed 863 times | icon graph PDF Article downloaded 935 times


Citations

/


[1]. Mohamed Sayed Behalo, Aly Abdelmaboud Aly, Ashraf Farouk Wasfy, Marwa Mohamed Rizk
Synthesis of some novel 1,2,4-triazole derivatives as potential antimicrobial agents
European Journal of Chemistry  4(2), 92, 2013
DOI: 10.5155/eurjchem.4.2.92-97.615
/

References


[1]. Butnariu, R. M.; Mangalagiu, I. I. Bioorg. Med. Chem. 2009, 17(7), 2823-2829.
http://dx.doi.org/10.1016/j.bmc.2009.02.028

[2]. Grey, R.; Pierce, A. C.; Bemis, G. W.; Jacobs, M. D.; Moody, C. S.; Jajoo, R.; Mohal, N.; Green, J. Bioorg. Med. Chem. Lett. 2009, 19(11), 3019-3022.
http://dx.doi.org/10.1016/j.bmcl.2009.04.061

[3]. Shimizu, H.; Tanaka, S.; Toki, T.; Yasumatsu, I.; Akimoto, T.; Morishita, K.; Yamasaki, T.; Yasukochi, T.; Imura, S. Bioorg. Med. Chem. Lett. 2010, 20(17), 5113-5118.
http://dx.doi.org/10.1016/j.bmcl.2010.07.026

[4]. Stevens, K. L.; Reno, M. J.; Alberti, J. B.; Price, D. J.; Kane-Carson, L. S.; Knick, V. B.; Shewchuk, L. M.; Hassell, A. M.; Veal, J. M.; Davis, S. T.; Griffin, R. J.; Peel, M. R. Bioorg. Med. Chem. Lett. 2008, 18(21), 5758-5762.
http://dx.doi.org/10.1016/j.bmcl.2008.09.069

[5]. Leger, S.; Black, W. C.; Deschenes, D.; Dolman, S.; Falgueyret, J.; Gagnon, M.; Guiral, S.; Huang, Z.; Guay, J.; Leblanc, Y.; Massé, F.; Oballa, R.; Zhang, L. Bioorg. Med. Chem. Lett. 2010, 20(2), 499-502.
PMid:20004097

[6]. Tang, P. C.; Feng, J.; Huang, L.; Xu, Z.; Cheng, L.; Zhang, X.; Zhang, L.; Hu, B. Bioorg. Med. Chem. Lett. 2009, 19(22), 6437-6440.
http://dx.doi.org/10.1016/j.bmcl.2009.09.038

[7]. Gleave, R. J.; Beswick, P. J.; Brown, A. J.; Giblin, G. M.; Goldsmith, P.; Haslam, C. P.; Mitchell, W. L.; Nicholson, N. H.; Page, L. W.; Patel, S.; Roomans, S.; Slingsby, B. P.; Swarbrick M. E. Bioorg. Med. Chem. Lett. 2010, 20(2), 465-468.
http://dx.doi.org/10.1016/j.bmcl.2009.11.117

[8]. Kummerle, A. E.; Vieira, M. M.; Schmitt, M.; Miranda, A. L. P.; Fraga, C. A. M.; Bourguignon, J. J.; Barreiro, E. J. Bioorg. Med. Chem. Lett. 2009, 19(17), 4963-4966.
PMid:19646868

[9]. Abdel-Hafez, S. H. Eur. J. Med. Chem. 2008, 43(9), 1971-1977.
http://dx.doi.org/10.1016/j.ejmech.2007.12.006
PMid:18242782

[10]. Rodrguez-Ciria, M.; Sanz, A. M.; Yunta, M. J. R.; Gomez-Contreras, F.; Navarro, P.; Fernandez, I.; Pardo, M.; Cano, C. Bioorg. Med. Chem. 2003, 11, 2143-2147.
http://dx.doi.org/10.1016/S0968-0896(03)00127-5

[11]. Bloomer, L. C.; Wotring, L. L.; Townsend, L. B. Cancer Res. 1982, 25, 813-819.

[12]. Garcia, M. H.; Morais, T. S.; Florindo, P.; Piedade, M. F.; Moreno, V.; Ciudad, C.; Noe, V. J. Inorg. Biochem. 2009, 103(3), 354-361.
http://dx.doi.org/10.1016/j.jinorgbio.2008.11.016
PMid:19128838

[13]. Mantu, D.; Luca, M. C.; Moldoveanu, C.; Zbancioc, G.; Mangalagiu, I. I. Eur. J. Med. Chem. 2010, 45(11), 5164-5168.
http://dx.doi.org/10.1016/j.ejmech.2010.08.029
PMid:20813433

[14]. Demirayak, S.; Karaburn, A. C.; Beis, R. Eur. J. Med. Chem. 2004, 39, 1089-1093.
http://dx.doi.org/10.1016/j.ejmech.2004.09.005
PMid:15571871

[15]. Gokce, M.; Dogruer, D.; Fethi Sahin, M. Farmaco II, 2001, 56, 223-228.

[16]. Butnariu, R.; Caprosu, M.; Bejan, V.; Ungureanu, M.; Poiata, A.; Tuchilus, C.; Florescu, M.; Mangalagiu, I. I. J. Heterocycl. Chem. 2007, 44, 1149-1155.
http://dx.doi.org/10.1002/jhet.5570440528

[17]. Caprosu, M.; Butnariu, R.; Mangalagiu, I. I. Heterocycles 2005, 65, 1871-1875.
http://dx.doi.org/10.3987/COM-05-10428

[18]. Ungureanu, M.; Mangalagiu, I. I.; Grosu, G.; Petrovanu, M. Ann. Pharm. Fr. 1997, 55, 69-74.
PMid:9181703

[19]. Kandile, N. G.; Mohamed, M. I.; Zaky, H.; Mohamed, H. M. Eur. J. Med. Chem. 2009, 44(5), 1989-1996.
http://dx.doi.org/10.1016/j.ejmech.2008.09.047
PMid:19013692

[20]. Guan, L. P.; Sui, X.; Deng, X. Q.; Quan, Y. C.; Quan, Z. S. Eur. J. Med. Chem. 2010, 45, 1746-1752
http://dx.doi.org/10.1016/j.ejmech.2009.12.077
PMid:20116141

[21]. Attanasi, O. A.; Crescentini, L. D.; Favi, G.; Filippone, P.; Giorgi, G.; Mantellini, F.; Moscatelli, G.; Behalo, M. S. Org. Lett. 2009, 11(11), 2265-2268.
http://dx.doi.org/10.1021/ol900545v
PMid:19397335

[22]. Issac, Y. A.; El-Karim, I. G.; Donia, S. G. and Behalo, M. S. Sulf. Lett. 2002, 25(4), 183-190.
http://dx.doi.org/10.1080/02786110213977

[23]. Issac, Y. A.; El-Karim, I. G.; Behalo, M. S.; Aly, A. A.; Donia, S. G. Olaj, Szappan, Kozmetika 2008, 57(4), 128-132.

[24]. Behalo, M. S. Phosphorus, Sulfur and Silicon and the Relat. Elements, 2009, 184(1), 206-219.
http://dx.doi.org/10.1080/10426500802095764

[25]. Donia, S. G.; Essawy S. A.; El-Sawy, A. A.; Farouk, A. A. J. Serb. Chem. Soc. 1988, 53, 543-550.


How to cite


Behalo, M.; Aly, A. Eur. J. Chem. 2011, 2(3), 295-299. doi:10.5155/eurjchem.2.3.295-299.376
Behalo, M.; Aly, A. Synthesis of nitrogen heterocycles from ethyl 3-(6-dibenzothiophen-2-yl-pyridazin-3-ylamino)-3-oxopropanoate. Eur. J. Chem. 2011, 2(3), 295-299. doi:10.5155/eurjchem.2.3.295-299.376
Behalo, M., & Aly, A. (2011). Synthesis of nitrogen heterocycles from ethyl 3-(6-dibenzothiophen-2-yl-pyridazin-3-ylamino)-3-oxopropanoate. European Journal of Chemistry, 2(3), 295-299. doi:10.5155/eurjchem.2.3.295-299.376
Behalo, Mohamed, & Aly Abdelmaboud Aly. "Synthesis of nitrogen heterocycles from ethyl 3-(6-dibenzothiophen-2-yl-pyridazin-3-ylamino)-3-oxopropanoate." European Journal of Chemistry [Online], 2.3 (2011): 295-299. Web. 5 Mar. 2021
Behalo, Mohamed, AND Aly, Aly. "Synthesis of nitrogen heterocycles from ethyl 3-(6-dibenzothiophen-2-yl-pyridazin-3-ylamino)-3-oxopropanoate" European Journal of Chemistry [Online], Volume 2 Number 3 (30 September 2011)

The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item



DOI Link: https://doi.org/10.5155/eurjchem.2.3.295-299.376

CrossRef | Scilit | GrowKudos | Researchgate | Publons | Microsoft | scibey | Scite | Lens | OUCI

WorldCat Paperbuzz Citeas | Dimensions | Semanticscholar | Plumx | Kopernio | Zotero | Mendeley

ZoteroSave to Zotero MendeleySave to Mendeley



European Journal of Chemistry 2011, 2(3), 295-299 | doi: https://doi.org/10.5155/eurjchem.2.3.295-299.376 | Get rights and content

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c)




© Copyright 2010 - 2021 • Atlanta Publishing House LLC • All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2010-2021 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.