European Journal of Chemistry

Synthesis of nitrogen heterocycles from ethyl 3-(6-dibenzothiophen-2-yl-pyridazin-3-ylamino)-3-oxopropanoate

Article Sidebar

PDF
Published: Sep 30, 2011
DOI: https://doi.org/10.5155/eurjchem.2.3.295-299.376
Keywords:
Dibenzothiophene, Pyridazine, Triazole, Pyrimidinone, Pyrazole, Pyridinone
Section
Research Article
Issue
Vol. 2 No. 3 (2011): September 2011
Dates
Received 2010-12-24
Accepted 2011-03-29
Published 2011-09-30


Main Article Content

Mohamed Sayed Behalo
Department of Chemistry, Faculty of Science, Benha University, Benha, 13518, Egypt
Aly Abdelmaboud Aly
Department of Chemistry, Faculty of Science, Benha University, Benha, 13518, Egypt

Abstract

An efficient synthesis of nitrogen-containing heterocycles pyrazole, triazole,  pyridinone and pyrimidinone derivatives from ethyl 3-(6-dibenzothiophen-2-yl-pyridazin-3-ylamino)-3-oxopropanoate (2) was described. The structures of all products were confirmed and characterized by the elemental analysis and spectroscopic studies (IR, MS, 1H NMR, 13C NMR).

2_3_295_299_800


icon graph This Abstract was viewed 2438 times | icon graph Article PDF downloaded 1640 times

How to Cite
(1)
Behalo, M. S.; Aly, A. A. Synthesis of Nitrogen Heterocycles from Ethyl 3-(6-Dibenzothiophen-2-Yl-Pyridazin-3-Ylamino)-3-Oxopropanoate. Eur. J. Chem. 2011, 2, 295-299.

Article Details

Share
Links for Article


Crossref - Scopus - Google - European PMC
Crossref
Scopus
Google Scholar
Europe PMC
References

[1]. Butnariu, R. M.; Mangalagiu, I. I. Bioorg. Med. Chem. 2009, 17(7), 2823-2829.
http://dx.doi.org/10.1016/j.bmc.2009.02.028

[2]. Grey, R.; Pierce, A. C.; Bemis, G. W.; Jacobs, M. D.; Moody, C. S.; Jajoo, R.; Mohal, N.; Green, J. Bioorg. Med. Chem. Lett. 2009, 19(11), 3019-3022.
http://dx.doi.org/10.1016/j.bmcl.2009.04.061

[3]. Shimizu, H.; Tanaka, S.; Toki, T.; Yasumatsu, I.; Akimoto, T.; Morishita, K.; Yamasaki, T.; Yasukochi, T.; Imura, S. Bioorg. Med. Chem. Lett. 2010, 20(17), 5113-5118.
http://dx.doi.org/10.1016/j.bmcl.2010.07.026

[4]. Stevens, K. L.; Reno, M. J.; Alberti, J. B.; Price, D. J.; Kane-Carson, L. S.; Knick, V. B.; Shewchuk, L. M.; Hassell, A. M.; Veal, J. M.; Davis, S. T.; Griffin, R. J.; Peel, M. R. Bioorg. Med. Chem. Lett. 2008, 18(21), 5758-5762.
http://dx.doi.org/10.1016/j.bmcl.2008.09.069

[5]. Leger, S.; Black, W. C.; Deschenes, D.; Dolman, S.; Falgueyret, J.; Gagnon, M.; Guiral, S.; Huang, Z.; Guay, J.; Leblanc, Y.; Massé, F.; Oballa, R.; Zhang, L. Bioorg. Med. Chem. Lett. 2010, 20(2), 499-502.
PMid:20004097

[6]. Tang, P. C.; Feng, J.; Huang, L.; Xu, Z.; Cheng, L.; Zhang, X.; Zhang, L.; Hu, B. Bioorg. Med. Chem. Lett. 2009, 19(22), 6437-6440.
http://dx.doi.org/10.1016/j.bmcl.2009.09.038

[7]. Gleave, R. J.; Beswick, P. J.; Brown, A. J.; Giblin, G. M.; Goldsmith, P.; Haslam, C. P.; Mitchell, W. L.; Nicholson, N. H.; Page, L. W.; Patel, S.; Roomans, S.; Slingsby, B. P.; Swarbrick M. E. Bioorg. Med. Chem. Lett. 2010, 20(2), 465-468.
http://dx.doi.org/10.1016/j.bmcl.2009.11.117

[8]. Kummerle, A. E.; Vieira, M. M.; Schmitt, M.; Miranda, A. L. P.; Fraga, C. A. M.; Bourguignon, J. J.; Barreiro, E. J. Bioorg. Med. Chem. Lett. 2009, 19(17), 4963-4966.
PMid:19646868

[9]. Abdel-Hafez, S. H. Eur. J. Med. Chem. 2008, 43(9), 1971-1977.
http://dx.doi.org/10.1016/j.ejmech.2007.12.006
PMid:18242782

[10]. Rodrguez-Ciria, M.; Sanz, A. M.; Yunta, M. J. R.; Gomez-Contreras, F.; Navarro, P.; Fernandez, I.; Pardo, M.; Cano, C. Bioorg. Med. Chem. 2003, 11, 2143-2147.
http://dx.doi.org/10.1016/S0968-0896(03)00127-5

[11]. Bloomer, L. C.; Wotring, L. L.; Townsend, L. B. Cancer Res. 1982, 25, 813-819.

[12]. Garcia, M. H.; Morais, T. S.; Florindo, P.; Piedade, M. F.; Moreno, V.; Ciudad, C.; Noe, V. J. Inorg. Biochem. 2009, 103(3), 354-361.
http://dx.doi.org/10.1016/j.jinorgbio.2008.11.016
PMid:19128838

[13]. Mantu, D.; Luca, M. C.; Moldoveanu, C.; Zbancioc, G.; Mangalagiu, I. I. Eur. J. Med. Chem. 2010, 45(11), 5164-5168.
http://dx.doi.org/10.1016/j.ejmech.2010.08.029
PMid:20813433

[14]. Demirayak, S.; Karaburn, A. C.; Beis, R. Eur. J. Med. Chem. 2004, 39, 1089-1093.
http://dx.doi.org/10.1016/j.ejmech.2004.09.005
PMid:15571871

[15]. Gokce, M.; Dogruer, D.; Fethi Sahin, M. Farmaco II, 2001, 56, 223-228.

[16]. Butnariu, R.; Caprosu, M.; Bejan, V.; Ungureanu, M.; Poiata, A.; Tuchilus, C.; Florescu, M.; Mangalagiu, I. I. J. Heterocycl. Chem. 2007, 44, 1149-1155.
http://dx.doi.org/10.1002/jhet.5570440528

[17]. Caprosu, M.; Butnariu, R.; Mangalagiu, I. I. Heterocycles 2005, 65, 1871-1875.
http://dx.doi.org/10.3987/COM-05-10428

[18]. Ungureanu, M.; Mangalagiu, I. I.; Grosu, G.; Petrovanu, M. Ann. Pharm. Fr. 1997, 55, 69-74.
PMid:9181703

[19]. Kandile, N. G.; Mohamed, M. I.; Zaky, H.; Mohamed, H. M. Eur. J. Med. Chem. 2009, 44(5), 1989-1996.
http://dx.doi.org/10.1016/j.ejmech.2008.09.047
PMid:19013692

[20]. Guan, L. P.; Sui, X.; Deng, X. Q.; Quan, Y. C.; Quan, Z. S. Eur. J. Med. Chem. 2010, 45, 1746-1752
http://dx.doi.org/10.1016/j.ejmech.2009.12.077
PMid:20116141

[21]. Attanasi, O. A.; Crescentini, L. D.; Favi, G.; Filippone, P.; Giorgi, G.; Mantellini, F.; Moscatelli, G.; Behalo, M. S. Org. Lett. 2009, 11(11), 2265-2268.
http://dx.doi.org/10.1021/ol900545v
PMid:19397335

[22]. Issac, Y. A.; El-Karim, I. G.; Donia, S. G. and Behalo, M. S. Sulf. Lett. 2002, 25(4), 183-190.
http://dx.doi.org/10.1080/02786110213977

[23]. Issac, Y. A.; El-Karim, I. G.; Behalo, M. S.; Aly, A. A.; Donia, S. G. Olaj, Szappan, Kozmetika 2008, 57(4), 128-132.

[24]. Behalo, M. S. Phosphorus, Sulfur and Silicon and the Relat. Elements, 2009, 184(1), 206-219.
http://dx.doi.org/10.1080/10426500802095764

[25]. Donia, S. G.; Essawy S. A.; El-Sawy, A. A.; Farouk, A. A. J. Serb. Chem. Soc. 1988, 53, 543-550.

Supporting Agencies

Most read articles by the same author(s)

Most read articles by the same author(s)

TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2026 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).