Synthesis of some novel 1,2,4-triazole derivatives as potential antimicrobial agents
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Accepted 2012-06-05
Published 2013-06-30
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Abstract
An efficient synthesis of 1,2,4-triazole derivatives, fused to five and six membered rings from 4-amino-5-[(quinolin-8-yloxy)methyl]-4H-1,2,4-triazole-3-thiole (2) was described. The structural formula of all derivatives was confirmed and characterized by elemental analysis and spectral studies. Some of the synthesized compounds were also investigated for their antibacterial and antifungal activities and compared with standard drugs. Most of the tested compounds demonstrated potent to weak antimicrobial activities.
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Chemistry Department, Faculty of Science, Benha University, Egypt
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