

Synthesis of some novel 1,2,4-triazole derivatives as potential antimicrobial agents
Mohamed Sayed Behalo (1,*)




(1) Chemistry Department, Faculty of Science, Benha University, Benha, 13518, Egypt
(2) Chemistry Department, Faculty of Science, Benha University, Benha, 13518, Egypt
(3) Chemistry Department, Faculty of Science, Benha University, Benha, 13518, Egypt
(4) Chemistry Department, Faculty of Science, Benha University, Benha, 13518, Egypt
(*) Corresponding Author
Received: 18 Apr 2012 | Accepted: 05 Jun 2012 | Published: 30 Jun 2013 | Issue Date: June 2013
Abstract
An efficient synthesis of 1,2,4-triazole derivatives, fused to five and six membered rings from 4-amino-5-[(quinolin-8-yloxy)methyl]-4H-1,2,4-triazole-3-thiole (2) was described. The structural formula of all derivatives was confirmed and characterized by elemental analysis and spectral studies. Some of the synthesized compounds were also investigated for their antibacterial and antifungal activities and compared with standard drugs. Most of the tested compounds demonstrated potent to weak antimicrobial activities.

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DOI: 10.5155/eurjchem.4.2.92-97.615
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Chemistry Department, Faculty of Science, Benha University, Egypt
Citations
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[4]. Isabela A. Graciano, Alcione S. de Carvalho, Fernando de Carvalho da Silva, Vitor F. Ferreira
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[5]. M. S. Behalo, M. S. Amine, I. M. Fouda
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