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Synthesis of some novel 1,2,4-triazole derivatives as potential antimicrobial agents
Mohamed Sayed Behalo (1,*)
, Aly Abdelmaboud Aly (2) , Ashraf Farouk Wasfy (3) , Marwa Mohamed Rizk (4) (1) Chemistry Department, Faculty of Science, Benha University, Benha, 13518, Egypt
(2) Chemistry Department, Faculty of Science, Benha University, Benha, 13518, Egypt
(3) Chemistry Department, Faculty of Science, Benha University, Benha, 13518, Egypt
(4) Chemistry Department, Faculty of Science, Benha University, Benha, 13518, Egypt
(*) Corresponding Author
Received: 18 Apr 2012 | Accepted: 05 Jun 2012 | Published: 30 Jun 2013 | Issue Date: June 2013
Abstract
An efficient synthesis of 1,2,4-triazole derivatives, fused to five and six membered rings from 4-amino-5-[(quinolin-8-yloxy)methyl]-4H-1,2,4-triazole-3-thiole (2) was described. The structural formula of all derivatives was confirmed and characterized by elemental analysis and spectral studies. Some of the synthesized compounds were also investigated for their antibacterial and antifungal activities and compared with standard drugs. Most of the tested compounds demonstrated potent to weak antimicrobial activities.
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DOI: 10.5155/eurjchem.4.2.92-97.615
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Chemistry Department, Faculty of Science, Benha University, Egypt
Citations
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[3]. Christophe Tratrat
1,2,4-Triazole: A Privileged Scaffold for the Development of Potent Antifungal Agents - A Brief Review
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[4]. Isabela A. Graciano, Alcione S. de Carvalho, Fernando de Carvalho da Silva, Vitor F. Ferreira
1,2,3-Triazole- and Quinoline-based Hybrids with Potent Antiplasmodial Activity
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[5]. M. S. Behalo, M. S. Amine, I. M. Fouda
Regioselective synthesis, antitumor and antioxidant activities of some 1,2,4-triazole derivatives based on 4-phenyl-5-(quinolin-8-yloxy)methyl-4H-1,2,4-triazole-3-thiol
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[6]. Milenca Mariana Vorga, Valentin Badea
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[7]. Małgorzata Strzelecka, Piotr Świątek
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[8]. Bharat Kumar Bugata, Satya Venkata Gopala Kaladhar Dowluru, Vasudeva Rao Avupati, Venkateswara Rao Gavalapu, Divakara Laxman Somayajulu Nori, Sreenu Barla
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References
[1]. Karabasanagouda, T.; Adhikari, A. V.; Shetty, N. S. Eur. J. Med. Chem. 2007, 42, 521-525.
http://dx.doi.org/10.1016/j.ejmech.2006.10.010
PMid:17156898
[2]. Mudasir, R. B.; Abdulrauf, A. Ind. J. Chem. B 2009, 43, 97-102.
[3]. Nirmala, K.; Parimala, S. Ind. J. Heterocycl. Chem. 2008, 17, 331-334.
[4]. Sztanke, K.; Tuzimski, T.; Rzymowska, J.; Pasternak, K.; Kanadefer, S. M. Eur. J. Med. Chem. 2008, 43(2), 404-409.
http://dx.doi.org/10.1016/j.ejmech.2007.03.033
PMid:17531354
[5]. Harendra, S.; Manoj, K. S. Ind. J. Chem. B 2001, 40, 159-162.
[6]. Zareef, M.; Iqbal, R.; Mirza, B.; Khalid, M. K.; Manan, A.; Asim, F.; Khan, S.W. Arkivoc 2008, 2, 141-152.
http://dx.doi.org/10.3998/ark.5550190.0009.216
[7]. Almasirad, A.; Tabatabai, S. A.; Faizi, M; Kebria, A; Mehrabi, N; Dalavand, A; Shafiee, A. Bioorg. Med. Chem. 2004, 14, 6057-6061.
http://dx.doi.org/10.1016/j.bmcl.2004.09.072
PMid:15546729
[8]. Tozkoparan, B.; Kupeli, E.; Yesilada, E.; Isil, S.; Ozalp, M.; Ertan, M. Arznei. Forschung 2005, 55(9), 533-538.
PMid:16229118
[9]. Shashikant, V. B.; Kailash, G. B.; Aniket, P. S.; Ajit, A.; Chetan, V. K.; Sudarshan, C. D. Pharmacologyonline 2008, 2, 572-587.
[10]. Giorgio, R.; Giancarlo, G.; Mario, D. B.; Daniela, P.; Vigilio, B.; Massimiliano, T.; Simona, B.; Elisabetta, B. Eur. J. Med. 2008, 43, 1665-1680.
http://dx.doi.org/10.1016/j.ejmech.2007.10.010
PMid:18045747
[11]. Menendez, C.; Chollet, A.; Rodriguez, F.; Inard, C.; Pasca, M.; Lherbet, C.; Baltas, M. Eur. J. Med. Chem. 2012, 52, 275-283
http://dx.doi.org/10.1016/j.ejmech.2012.03.029
PMid:22483635
[12]. Kucukguzel, I.; Guniz-Kucukguzel, S.; Rollas, S.; Otuk-Sanis, G.; Ozdemir, O.; Bayrak, I.; Altug, T.; Stables, J. II Farmaco 2004, 59(11), 893-901.
http://dx.doi.org/10.1016/j.farmac.2004.07.005
PMid:15544794
[13]. Nadeem, S.; Mash, A.; Waqua, R. A. Acta Pharm. 2008, 58, 445-454.
[14]. Jing, C.; Xian-Yu, S.; Kyu-Yun, C.; Jin-Seok, L.; Mi-Sun, S.; Zhe-Shan, Q. B. Med. Chem. 2007, 15, 6775-6781.
http://dx.doi.org/10.1016/j.bmc.2007.08.004
PMid:17761423
[15]. Mohamd, A.; Harish, K. Ind. J. Chem. 2007, 46, 1014-1019.
[16]. Padmavathi, V.; Sudhakar, G. R.; Padmaja, A.; Kondaiah, P.; Ali, S. Eur. J. Med. 2009, 44, 2106-2112.
http://dx.doi.org/10.1016/j.ejmech.2008.10.012
PMid:19036476
[17]. Kane, J. M.; Dubley, M. W.; Sorensen, S. M.; Miller, F. P. J. Med. Chem. 1988, 31, 1253-1255.
http://dx.doi.org/10.1021/jm00401a031
[18]. Athanasia, V.; Theodora, S. P.; Andrew, T.; Anna, T. K.; Alexandra, V. II Farmaco 1998, 53, 320-326.
http://dx.doi.org/10.1016/S0014-827X(98)00024-X
[19]. Bing, C.; Xuhong, Q.; Song, C.; Haidong, L.; Gonghua, S. Arkivoc 2003, 2, 141-145.
[20]. Gamal, A. I.; Omar, M. A.; Gamal El-Din, A. A.; Abou-Rahma, M. F.; Radwan, M. Eur. J. Med. 2009, 45, 1-8.
[21]. Michael, S. M.; Janet, S.; Michael, M.; Iwan, G.; Brenda, M.; Donald, S. Eur. J. Med. 2001, 36, 31-42.
http://dx.doi.org/10.1016/S0223-5234(00)01191-0
[22]. Ouyang, X.; Piatnitski, E. L.; Pattaropong, V.; Chen, X.; He, H. Y.; Kiselyov, A. S.; Velankar, A.; Kawakami, J.; Labelle, M.; Smith, L.; Lohman, J.; Lee, S. P.; Malikzay, A.; Fleming, J.; Gerlak, J.; Wang, Y.; Rosler, R. L.; Zhou, K.; Mitelman, S.; Camara, M.; Surguladze, D.; Doody, J. F.; Tuma, M. C.Bioorg. Med. Chem. Lett. 2006, 16, 1191-1196.
http://dx.doi.org/10.1016/j.bmcl.2005.11.094
PMid:16377187
[23]. Priyadarsini, R.; Vijayaraj, T. K.; Ravi, C.; Praba, M. Ind. J. Heterocycl. Chem. 2004, 20, 165-166.
[24]. Udupi, R. H.; Bhat, A. R. Ind. J. Heterocycl. Chem. 1996, 6, 41-45.
[25]. Dhanabal, T.; Sangeetha, R.; Mohan, P. S. Tetrahedron 2006, 62, 6258-6262.
http://dx.doi.org/10.1016/j.tet.2006.04.050
[26]. Arzel, E.; Rocca, P.; Grellier, P.; Labaeid, M.; Frappier, F.; Gueritte, F.; Gaspard, C.; Marsais, F.; Godard, A.; Queguiner, G. J. Med. Chem. 2001, 44, 949-954.
http://dx.doi.org/10.1021/jm0010419
[27]. Aly, A. A.; Behalo, M. S. J. Chem. Res. 2010, 34(10), 571-575.
http://dx.doi.org/10.3184/030823410X12863009209478
[28]. Behalo, M. S.; Aly, A. A. Eur. J. Chem. 2011, 2(3), 295-299.
http://dx.doi.org/10.5155/eurjchem.2.3.295-299.376
[29]. Issac, Y. A.; El-Karim, I. G.; Donia, S. G.; Behalo, M. S. Sulf. Lett. 2002, 25(4), 183-190.
http://dx.doi.org/10.1080/02786110213977
[30]. Mohd, A.; Rajesh, A. Ind. J. Heterocycl. Chem. 1998, 7, 225-228.
[31]. Leifert, C.; Chidbouree, S.; Hampson, S.; Workman, S.; Sigee, D.; Epton, H. A. S.; Harbour, A. J. Appl. Bacteriol. 1995, 78, 97-102.
http://dx.doi.org/10.1111/j.1365-2672.1995.tb02829.x
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DOI Link: https://doi.org/10.5155/eurjchem.4.2.92-97.615
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European Journal of Chemistry 2013, 4(2), 92-97 | doi: https://doi.org/10.5155/eurjchem.4.2.92-97.615 | Get rights and content
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