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Novel approach for preparing nontoxic stealth microspheres for drug delivery
Pawan Kumar Angra (1)
, Syed Asad Ali Rizvi (2,*) , Carl William Oettinger (3) , Martin Joaquim D’Souza (4) (1) Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA, 30341, USA
(2) Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA, 30341, USA
(3) Dialysis Clinic Inc. Atlanta, GA, 30318, USA
(4) Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA, 30341, USA
(*) Corresponding Author
Received: 26 Jan 2011 | Accepted: 23 Feb 2011 | Published: 30 Jun 2011 | Issue Date: June 2011
Abstract
Polyethylene glycol 2000 (PEG) entrapped, bovine serum albumin (BSA) microspheres were prepared and optimized. These microspheres were then analyzed to understand the stealth effect to the microspheres imparted by incorporated polyethylene glycol (PEG). Microsphere preparations (formulations) were studied for particle size, zeta potential, free BSA content, and in-vitro uptake by human micro-vascular endothelial cells (HMECs). The results demonstrate, a formulation containing 37.5 % PEG (w/w) exhibits an acceptable particle size of <5 µm, good suspendibility with zeta potential of -35 mV, and confers some degree of stealth property to the microspheres. These non-toxic, biodegradable and long circulating microspheres have the potential to be used for extended intravenous (IV) drug delivery. Statistical analysis done by ANOVA and results with p<0.05 were considered significant.
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DOI: 10.5155/eurjchem.2.2.125-129.394
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Citations
[1]. Rainer Tietze, Stefan Lyer, Stephan Dürr, Tobias Struffert, Tobias Engelhorn, Marc Schwarz, Elisabeth Eckert, Thomas Göen, Serhiy Vasylyev, Wolfgang Peukert, Frank Wiekhorst, Lutz Trahms, Arnd Dörfler, Christoph Alexiou
Efficient drug-delivery using magnetic nanoparticles — biodistribution and therapeutic effects in tumour bearing rabbits
Nanomedicine: Nanotechnology, Biology and Medicine 9(7), 961, 2013
DOI: 10.1016/j.nano.2013.05.001
[2]. Abuzer Alp Yetisgin, Sibel Cetinel, Merve Zuvin, Ali Kosar, Ozlem Kutlu
Therapeutic Nanoparticles and Their Targeted Delivery Applications
Molecules 25(9), 2193, 2020
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[3]. Syed A.A. Rizvi, Ayman M. Saleh
Applications of nanoparticle systems in drug delivery technology
Saudi Pharmaceutical Journal 26(1), 64, 2018
DOI: 10.1016/j.jsps.2017.10.012
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DOI Link: https://doi.org/10.5155/eurjchem.2.2.125-129.394
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European Journal of Chemistry 2011, 2(2), 125-129 | doi: https://doi.org/10.5155/eurjchem.2.2.125-129.394 | Get rights and content
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