European Journal of Chemistry 2011, 2(2), 125-129 | doi: https://doi.org/10.5155/eurjchem.2.2.125-129.394 | Get rights and content

Issue cover





  Open Access OPEN ACCESS | Open Access PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS

Novel approach for preparing nontoxic stealth microspheres for drug delivery


Pawan Kumar Angra (1) , Syed Asad Ali Rizvi (2,*) , Carl William Oettinger (3) , Martin Joaquim D’Souza (4)

(1) Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA, 30341, USA
(2) Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA, 30341, USA
(3) Dialysis Clinic Inc. Atlanta, GA, 30318, USA
(4) Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA, 30341, USA
(*) Corresponding Author

Received: 26 Jan 2011 | Accepted: 23 Feb 2011 | Published: 30 Jun 2011 | Issue Date: June 2011

Abstract


Polyethylene glycol 2000 (PEG) entrapped, bovine serum albumin (BSA) microspheres were prepared and optimized. These microspheres were then analyzed to understand the stealth effect to the microspheres imparted by incorporated polyethylene glycol (PEG). Microsphere preparations (formulations) were studied for particle size, zeta potential, free BSA content, and in-vitro uptake by human micro-vascular endothelial cells (HMECs). The results demonstrate, a formulation containing 37.5 % PEG (w/w) exhibits an acceptable particle size of <5 µm, good suspendibility with zeta potential of -35 mV, and confers some degree of stealth property to the microspheres. These non-toxic, biodegradable and long circulating microspheres have the potential to be used for extended intravenous (IV) drug delivery. Statistical analysis done by ANOVA and results with p<0.05 were considered significant.2_2_125_129_800


Keywords


Stealth microspheres; Bovine serum albumin; Cross-linked albumin; Polyethylene glycol 2000; Spray drying; Polymers

Full Text:

PDF
PDF    Open Access

DOI: 10.5155/eurjchem.2.2.125-129.394

Links for Article


| | | | | | |

| | | | | | |

| | | |

Related Articles




Article Metrics

icon graph This Abstract was viewed 1248 times | icon graph PDF Article downloaded 263 times


Citations

/


[1]. Rainer Tietze, Stefan Lyer, Stephan Dürr, Tobias Struffert, Tobias Engelhorn, Marc Schwarz, Elisabeth Eckert, Thomas Göen, Serhiy Vasylyev, Wolfgang Peukert, Frank Wiekhorst, Lutz Trahms, Arnd Dörfler, Christoph Alexiou
Efficient drug-delivery using magnetic nanoparticles — biodistribution and therapeutic effects in tumour bearing rabbits
Nanomedicine: Nanotechnology, Biology and Medicine  9(7), 961, 2013
DOI: 10.1016/j.nano.2013.05.001
/


[2]. Abuzer Alp Yetisgin, Sibel Cetinel, Merve Zuvin, Ali Kosar, Ozlem Kutlu
Therapeutic Nanoparticles and Their Targeted Delivery Applications
Molecules  25(9), 2193, 2020
DOI: 10.3390/molecules25092193
/


[3]. Syed A.A. Rizvi, Ayman M. Saleh
Applications of nanoparticle systems in drug delivery technology
Saudi Pharmaceutical Journal  26(1), 64, 2018
DOI: 10.1016/j.jsps.2017.10.012
/


References


[1]. D’Souza, M. J.; Oettinger, C. W.; Milton, G. V. Drug Dev. Ind. Pharm. 1999, 25, 727-734.
doi:10.1081/DDC-100102232
PMid:10349558

[2]. Haswani, D. K.; Nettey, H.; Oettinger, C. W.; D'Souza, M. J. J. Microencapsul. 2006, 23, 875-886.
doi:10.1080/02652040601035093
PMid:17390629

[3]. Nettey, H.; Haswani, D. K.; Oettinger, C. W.; D'Souza, M. J. J. Microencapsul. 2006, 23, 632-642.
doi:10.1080/02652040600776564
PMid:17118879

[4]. Haswani, D. K.; Nettey, H.; D'Souza. M, J.; Oettinger, C. W. Drug Dev. Ind. Pharm. 2007, 33, 181-190.
doi:10.1080/03639040600865249
PMid:17454050

[5]. Lai, Y. H.; D'Souza. M, J. J. Microencapsul. 2007, 24, 235-252.
doi:10.1080/02652040601162608
PMid:17454435

[6]. Oettinger, C. W.; D’Souza, M. J.; Akhavein. N.; Pee, G. T.; Taylor, F. B.; Kinasewitz, G. T. J. Microencapsul. 2007, 24, 337-348.
doi:10.1080/02652040601162525
PMid:17497387

[7]. Zhaowei, J.; D’Souza, M. J.; Oettinger, C. W. J. Microencapsul. 2007, 24, 596-607.
doi:10.1080/02652040701453477
PMid:17654178

[8]. Kramer, P. A. J. Pharm. Sci. 1974, 63, 1646-1647.
doi:10.1002/jps.2600631044
PMid:4436811

[9]. Tomilson, E.; Schoolderwoerd, E. M. A.; McVie, J. G. Human serum albumin microspheres for intra-arterial drug targeting of cytostatic compounds. Microspheres and Drug Therapy, Ed. Davis, S. S. Amsterdam, The Netherlands Elsevier, pp. 75-91, 1984.

[10]. Gref, R.; Quellec, P.; Blunk, T.; Muller, R. H.; Verbavatz, J. M.; Langer, R. Adv. Drug. Deliv. Rev. 1995, 16, 215-233.
doi:10.1016/0169-409X(95)00026-4

[11]. Moghimi, S. M.; Hunter, C.; Murray, J. C. Pharmacol. Rev. 2001, 53, 283-318.
PMid:11356986

[12]. Huh, K. M.; Cho, Y. W.; Park, K. Drug Deliv. Tech. 2003, 3(5), URL: http://drugdeliverytech.com

[13]. Zara, G. P.; Bargoni. A.; Fundaro, A.; Vighetto, D.; Gasco, M. R. J. Drug Target. 2002, 10, 327-335.
doi:10.1080/10611860290031868
PMid:12164381

[14]. Marino, D. Drug Deliv. Tech. 2003, 3(5), URL: http://drugdeliverytech.com

[15]. Vladimir, P. T.; Trubetskoy, V. S. Adv. Drug. Deliv. Rev. 1995, 16, 141-155.
doi:10.1016/0169-409X(95)00022-Y

[16]. Stolnik, S.; Illum, L.; Davis, S. S. Adv. Drug. Deliv. Rev. 1995, 16, 195-214.
doi:10.1016/0169-409X(95)00025-3

[17]. Ho, E. A.; Ramsay, E.; Ginj, M.; Anantha, M.; Bregman, I.; Sy, J.; Woo, J.; Osooly-Talesh, M.; Yapp, D. T.; Bally, M. B. J. Pharm. Sci. 2010, 99, 2839-2853.
doi:10.1002/jps.21845
PMid:19569058

[18]. Ades, E. W.; Candal, F. J.; Swerlick, R. A.; George, V. G.; Summer, S.; Bosse, D. C.; Lawley, T. J. J. Invest. Dermatol. 1992, 99, 683-690.
doi:10.1111/1523-1747.ep12613748
PMid:1361507

[19]. Udenfriend, S. Science 1972, 178, 871-872.
doi:10.1126/science.178.4063.871
PMid:5085985

[20]. Sigma-Aldrich. Fluorescamine. Product Information Sheet # F9015, 2005.


How to cite


Angra, P.; Rizvi, S.; Oettinger, C.; D’Souza, M. Eur. J. Chem. 2011, 2(2), 125-129. doi:10.5155/eurjchem.2.2.125-129.394
Angra, P.; Rizvi, S.; Oettinger, C.; D’Souza, M. Novel approach for preparing nontoxic stealth microspheres for drug delivery. Eur. J. Chem. 2011, 2(2), 125-129. doi:10.5155/eurjchem.2.2.125-129.394
Angra, P., Rizvi, S., Oettinger, C., & D’Souza, M. (2011). Novel approach for preparing nontoxic stealth microspheres for drug delivery. European Journal of Chemistry, 2(2), 125-129. doi:10.5155/eurjchem.2.2.125-129.394
Angra, Pawan, Syed Asad Ali Rizvi, Carl William Oettinger, & Martin Joaquim D’Souza. "Novel approach for preparing nontoxic stealth microspheres for drug delivery." European Journal of Chemistry [Online], 2.2 (2011): 125-129. Web. 24 Oct. 2021
Angra, Pawan, Rizvi, Syed, Oettinger, Carl, AND D’Souza, Martin. "Novel approach for preparing nontoxic stealth microspheres for drug delivery" European Journal of Chemistry [Online], Volume 2 Number 2 (30 June 2011)

The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item



DOI Link: https://doi.org/10.5155/eurjchem.2.2.125-129.394

CrossRef | Scilit | GrowKudos | Researchgate | Publons | Microsoft | scibey | Scite | Lens | OUCI

WorldCat Paperbuzz | LibKey Citeas | Dimensions | Semanticscholar | Plumx | Kopernio | Zotero | Mendeley

ZoteroSave to Zotero MendeleySave to Mendeley



European Journal of Chemistry 2011, 2(2), 125-129 | doi: https://doi.org/10.5155/eurjchem.2.2.125-129.394 | Get rights and content

Refbacks

  • There are currently no refbacks.




Copyright (c)





© Copyright 2010 - 2021  Atlanta Publishing House LLC All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2010-2021 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.