European Journal of Chemistry 2011, 2(2), 125-129. doi:10.5155/eurjchem.2.2.125-129.394

Novel approach for preparing nontoxic stealth microspheres for drug delivery


Pawan Kumar Angra (1) , Syed Asad Ali Rizvi (2,*) , Carl William Oettinger (3) , Martin Joaquim D’Souza (4)

(1) Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA, 30341, USA
(2) Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA, 30341, USA
(3) Dialysis Clinic Inc. Atlanta, GA, 30318, USA
(4) Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA, 30341, USA
(*) Corresponding Author

Received: 26 Jan 2011, Accepted: 23 Feb 2011, Published: 30 Jun 2011

Abstract


Polyethylene glycol 2000 (PEG) entrapped, bovine serum albumin (BSA) microspheres were prepared and optimized. These microspheres were then analyzed to understand the stealth effect to the microspheres imparted by incorporated polyethylene glycol (PEG). Microsphere preparations (formulations) were studied for particle size, zeta potential, free BSA content, and in-vitro uptake by human micro-vascular endothelial cells (HMECs). The results demonstrate, a formulation containing 37.5 % PEG (w/w) exhibits an acceptable particle size of <5 µm, good suspendibility with zeta potential of -35 mV, and confers some degree of stealth property to the microspheres. These non-toxic, biodegradable and long circulating microspheres have the potential to be used for extended intravenous (IV) drug delivery. Statistical analysis done by ANOVA and results with p<0.05 were considered significant.2_2_125_129_800


Keywords


Stealth microspheres; Bovine serum albumin; Cross-linked albumin; Polyethylene glycol 2000; Spray drying; Polymers

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DOI: 10.5155/eurjchem.2.2.125-129.394

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[1]. Rainer Tietze, Stefan Lyer, Stephan Dürr, Tobias Struffert, Tobias Engelhorn, Marc Schwarz, Elisabeth Eckert, Thomas Göen, Serhiy Vasylyev, Wolfgang Peukert, Frank Wiekhorst, Lutz Trahms, Arnd Dörfler, Christoph Alexiou
Efficient drug-delivery using magnetic nanoparticles — biodistribution and therapeutic effects in tumour bearing rabbits
Nanomedicine: Nanotechnology, Biology and Medicine  9(7), 961, 2013
DOI: 10.1016/j.nano.2013.05.001
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[2]. Syed A.A. Rizvi, Ayman M. Saleh
Applications of nanoparticle systems in drug delivery technology
Saudi Pharmaceutical Journal  26(1), 64, 2018
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How to cite


Angra, P.; Rizvi, S.; Oettinger, C.; D’Souza, M. Eur. J. Chem. 2011, 2(2), 125-129. doi:10.5155/eurjchem.2.2.125-129.394
Angra, P.; Rizvi, S.; Oettinger, C.; D’Souza, M. Novel approach for preparing nontoxic stealth microspheres for drug delivery. Eur. J. Chem. 2011, 2(2), 125-129. doi:10.5155/eurjchem.2.2.125-129.394
Angra, P., Rizvi, S., Oettinger, C., & D’Souza, M. (2011). Novel approach for preparing nontoxic stealth microspheres for drug delivery. European Journal of Chemistry, 2(2), 125-129. doi:10.5155/eurjchem.2.2.125-129.394
Angra, Pawan, Syed Asad Ali Rizvi, Carl William Oettinger, & Martin Joaquim D’Souza. "Novel approach for preparing nontoxic stealth microspheres for drug delivery." European Journal of Chemistry [Online], 2.2 (2011): 125-129. Web. 19 Sep. 2019
Angra, Pawan, Rizvi, Syed, Oettinger, Carl, AND D’Souza, Martin. "Novel approach for preparing nontoxic stealth microspheres for drug delivery" European Journal of Chemistry [Online], Volume 2 Number 2 (30 June 2011)

DOI Link: https://doi.org/10.5155/eurjchem.2.2.125-129.394

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