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Facile synthesis of 3-(1-(4'-(3-chloro-2-(substituted phenyl)-4-oxoazetidin-1-yl)biphenyl-4-yl)-5-oxo-2-phenyl-1H-imidazol-4(5H)-ylidene)indolin-2-ones: β-Lactam derivatives as antimicrobes
Abha Bishnoi (1,*)
, Krishna Srivastava (2) , Suruchi Singh (3) , Chandrakant Mani Tripathi (4) (1) Department of Chemistry, Lucknow University, University Road, Lucknow-226007, India
(2) Department of Chemistry, Shri Ramswaroop Memorial College of Engineering and Management, Faizabad Road, Lucknow-227105, India.
(3) Department of Chemistry, Lucknow University, University Road, Lucknow-226007, India
(4) Division of Fermentation Technology, Central Drug Research Institute, Chattar Manzil Palace, Lucknow-226001, India
(*) Corresponding Author
Received: 06 Apr 2011 | Revised: 05 May 2011 | Accepted: 06 May 2011 | Published: 30 Sep 2011 | Issue Date: September 2011
Abstract
A facile synthesis of b-lactam derivatives; 3-(1-(4'-(3-chloro-2-(substituted phenyl)-4-oxoazetidin-1-yl)biphenyl-4-yl)-5-oxo-2-phenyl-1H-imidazol-4(5H)-ylidene)indolin-2-ones (6a-e) and 3-(1-(3-chloro-2-(substituted phenyl)-4-oxoazetidin-1-yl)-5-oxo-2-phenyl-1H-imidazol-4(5H)-ylidene)indolin-2-ones (7a-e) is described herein. The title compounds 6a-e and 7a-e were evaluated for their in vitro antimicrobial activity against Candida albicans and Bacillus subtilis respectively using a two fold serial dilution technique. Investigation revealed that 2-hydroxy phenyl function at b-lactam ring in compounds 6d and 7d is a key factor for both antifungal and antibacterial activity, as newly designed compounds 6d and 7d exhibited good biological activity with minimum inhibitory concentration (MIC)12.5 mg/mL against Candida albicans and Bacillus subtilis respectively.
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DOI: 10.5155/eurjchem.2.3.359-364.439
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University Grants Commission, Central Drug Research Institute, India
Citations
[1]. Nikhilesh Arya, Archana Y. Jagdale, Tushar A. Patil, Shradha S. Yeramwar, Sidharam S. Holikatti, Jaya Dwivedi, Chamanlal J. Shishoo, Kishor S. Jain
The chemistry and biological potential of azetidin-2-ones
European Journal of Medicinal Chemistry 74, 619, 2014
DOI: 10.1016/j.ejmech.2014.01.002
[2]. Abha Bishnoi, Anil Kumar Tiwari, Suruchi Singh, Arun Sethi, Chandrakant Mani Tripathi, Bikram Banerjee
Synthesis, characterization, and biological evaluation of novel thiazole and pyrazole derivatives of quinoline-4-carboxylic acid as potential antimicrobial agents
Medicinal Chemistry Research 22(7), 3527, 2013
DOI: 10.1007/s00044-012-0333-2
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DOI Link: https://doi.org/10.5155/eurjchem.2.3.359-364.439
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European Journal of Chemistry 2011, 2(3), 359-364 | doi: https://doi.org/10.5155/eurjchem.2.3.359-364.439 | Get rights and content
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