European Journal of Chemistry 2012, 3(4), 406-410 | doi: https://doi.org/10.5155/eurjchem.3.4.406-410.476 | Get rights and content

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Synthesis and in-vitro antibacterial activity of some bis-5-(thiophen-2-yl)-carbothioamide-pyrazoline derivatives


Mamta Rani (1,*) , Mohamad Yusuf (2)

(1) Department of Chemistry, Punjabi University, Patiala, Punjab, 147002, India
(2) Department of Chemistry, Punjabi University, Patiala, Punjab, 147002, India
(*) Corresponding Author

Received: 08 Jun 2011 | Revised: 02 Sep 2011 | Accepted: 15 Sep 2011 | Published: 31 Dec 2012 | Issue Date: December 2012

Abstract


Five new compounds, bis-pyrazoline derivatives (2a-e) with antibacterial properties, built around the alkyl chains of varying lengths were prepared via reaction of various 1-ω-alkoxy-bis-chalcones with N-substituted thiosemicarbazide in ethanolic NaOH solution. The antibacterial activity of these compounds were evaluated by the disk diffusion method against two Gram-positive and two Gram-negative bacteria and the minimum inhibitory concentration were determined. The structures of these compounds were elucidated by IR, 1H-NMR, 13C-NMR, ESI mass spectrometry and their purities were also confirmed by elemental analyses. The formation and stereochemical features of the compounds, 2a-e, are found to be independent of the internal spacer length. The results showed that compounds 2a and 2e are better antibacterial agent compared to Gentamicin and Tetracycline.

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Keywords


Gentamicin; Tetracycline; Bis-chalcones; Bis-prazolines; Thiosemicarbazide; Antibacterial activity

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DOI: 10.5155/eurjchem.3.4.406-410.476

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Funding information


Rajiv Gandhi fellowship (Junior & Senior Research Fellowship, JRF & SRF (UGC)), N. Delhi, India and Department of Chemistry, Punjabi University, Patiala, India

Citations

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[1]. Maysoon Mohammed Almahdi, Ahmed Elsadig Mohammed Saeed, Nadia Hanafy Metwally
Synthesis and antimicrobial activity of some new pyrazoline derivatives bearing sulfanilamido moiety
European Journal of Chemistry  10(1), 30, 2019
DOI: 10.5155/eurjchem.10.1.30-36.1791
/


References


[1]. World Health Organization (WHO). "Guidelines for drinking-water quality", First Addendum to third edition, Geneva, 2006, 1,

[2]. Levai, A. Chem. Heterocyclic Compd. 1997, 33, 647-659.
http://dx.doi.org/10.1007/BF02291794

[3]. Ozdemir, Z; Kandilli, B.; Gumus, B. Euro. J. Med. Chem. 2007, 42, 309-315.

[4]. Brzozwski, Z.; Czewski, F. S.; Gdaniec, M. Euro. J. Med. Chem. 2000, 35, 1053-1064.
http://dx.doi.org/10.1016/S0223-5234(00)01194-6

[5]. Turan-Zitouni, G.; Ozdemir, A.; Guven, K. Arch. Pharm. 2005, 338, 96-104.
http://dx.doi.org/10.1002/ardp.200400935
PMid:15765490

[6]. Turan-Zitouni, G.; Ozdemir, A.; Kaplancikli, Z. A.; Chevallet P, Tunalı, Y. Phosphorus Sulfur 2005, 180, 2717-2724.
http://dx.doi.org/10.1080/104265090930452

[7]. Ozdemir, A.; Turan-Zitouni, G.; Kaplancikili, Z. A.; Revial, G.; Guven, K. Eur. J. Med. Chem. 2007, 42, 403-409.
http://dx.doi.org/10.1016/j.ejmech.2006.10.001
PMid:17125888

[8]. Shaharyar, M.; Siddiqui, A. A.; Ali, M. A.; Sriram, D.; Yogeeswari, P. Bioorg. Med. Chem. Lett. 2006, 16, 3947-3949.
http://dx.doi.org/10.1016/j.bmcl.2006.05.024
PMid:16725324

[9]. Nugent, R. A.; Murphy, M.; Schlachter, S. T.; Dunn, C. J.; Smith, R. J.; Staite, N. D.; Galinet, L. A.; Shields, S. K.; Aspar, D. G.; Richard, K. A.; Rohloff, N. A. J. Med. Chem. 1993, 36, 134-139.
http://dx.doi.org/10.1021/jm00053a017

[10]. Manna, F.; Chimenti, F.; Bolasco, A.; Cenicola, M. L.; D'Amico, M. Parrillo, C.; Rossi, F.; Marmo, E. Eur. J. Med. Chem. 1992, 27, 633-639.
http://dx.doi.org/10.1016/0223-5234(92)90142-N

[11]. Bazzanini, M.; Giovanni, B.; Pier, R.; Mario, G.; Daniele, S.; Maria, E. M.; Akssandra, P.; Enzo, T.; Paolo, C. J. Med. Chem. 1992, 35, 917-924.
http://dx.doi.org/10.1021/jm00083a017

[12]. Chetan, B. P.; Sreenivas, M. T.; Bhat, A. R. Ind. J. Heterocyclic Chem. 2004, 13, 225-228.

[13]. Bilgin, A. A.; Palaska, E.; Sunal, R. Arzneim. Forsch. Drug Res. 1993, 43, 1041-1044.

[14]. Bilgin, A. A.; Palaska, E.; Sunal, R.; Gumusel, B. Pharmazie 1994, 49, 67-69.
PMid:8140135

[15]. Raiford, L. C.; Peterson, W. J. J. Org. Chem. 1937, 1, 544-551.
http://dx.doi.org/10.1021/jo01235a003

[16]. Rani, M.; Yusuf, M. Eur. J. Chem. 2012, 3(1), 21-25.
http://dx.doi.org/10.5155/eurjchem.3.1.21-25.472

[17]. Khan, S. A.; Yusuf, M. Eur. J. Med. Chem. 2009, 44, 2270-2274.
http://dx.doi.org/10.1016/j.ejmech.2008.06.008
PMid:18715679

[18]. Husain, K.; Abid, M.; Azam A. Eur. J. Med. Chem. 2008, 43, 393-403.
http://dx.doi.org/10.1016/j.ejmech.2007.03.021
PMid:17513021

[19]. Khan, S. A.; Yusuf, M. Eur. J. Med. Chem. 2009, 44, 2597-2600.
http://dx.doi.org/10.1016/j.ejmech.2008.09.004
PMid:19211172

[20]. Bhat, A. R.; Athar, F.; Amir, A. Eur. J. Med. Chem. 2009, 44, 426-431.
http://dx.doi.org/10.1016/j.ejmech.2007.11.005
PMid:18187238

[21]. Bauer, A. W.; Kirby, W. M. M.; Sherris, J. C.; Truck, M. Am. J. Clin. Pathol. 1966, 36, 493-496.


How to cite


Rani, M.; Yusuf, M. Eur. J. Chem. 2012, 3(4), 406-410. doi:10.5155/eurjchem.3.4.406-410.476
Rani, M.; Yusuf, M. Synthesis and in-vitro antibacterial activity of some bis-5-(thiophen-2-yl)-carbothioamide-pyrazoline derivatives. Eur. J. Chem. 2012, 3(4), 406-410. doi:10.5155/eurjchem.3.4.406-410.476
Rani, M., & Yusuf, M. (2012). Synthesis and in-vitro antibacterial activity of some bis-5-(thiophen-2-yl)-carbothioamide-pyrazoline derivatives. European Journal of Chemistry, 3(4), 406-410. doi:10.5155/eurjchem.3.4.406-410.476
Rani, Mamta, & Mohamad Yusuf. "Synthesis and in-vitro antibacterial activity of some bis-5-(thiophen-2-yl)-carbothioamide-pyrazoline derivatives." European Journal of Chemistry [Online], 3.4 (2012): 406-410. Web. 26 Nov. 2022
Rani, Mamta, AND Yusuf, Mohamad. "Synthesis and in-vitro antibacterial activity of some bis-5-(thiophen-2-yl)-carbothioamide-pyrazoline derivatives" European Journal of Chemistry [Online], Volume 3 Number 4 (31 December 2012)

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European Journal of Chemistry 2012, 3(4), 406-410 | doi: https://doi.org/10.5155/eurjchem.3.4.406-410.476 | Get rights and content

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