

Synthesis and in-vitro antibacterial activity of some bis-5-(thiophen-2-yl)-carbothioamide-pyrazoline derivatives
Mamta Rani (1,*)


(1) Department of Chemistry, Punjabi University, Patiala, Punjab, 147002, India
(2) Department of Chemistry, Punjabi University, Patiala, Punjab, 147002, India
(*) Corresponding Author
Received: 08 Jun 2011 | Revised: 02 Sep 2011 | Accepted: 15 Sep 2011 | Published: 31 Dec 2012 | Issue Date: December 2012
Abstract
Five new compounds, bis-pyrazoline derivatives (2a-e) with antibacterial properties, built around the alkyl chains of varying lengths were prepared via reaction of various 1-ω-alkoxy-bis-chalcones with N-substituted thiosemicarbazide in ethanolic NaOH solution. The antibacterial activity of these compounds were evaluated by the disk diffusion method against two Gram-positive and two Gram-negative bacteria and the minimum inhibitory concentration were determined. The structures of these compounds were elucidated by IR, 1H-NMR, 13C-NMR, ESI mass spectrometry and their purities were also confirmed by elemental analyses. The formation and stereochemical features of the compounds, 2a-e, are found to be independent of the internal spacer length. The results showed that compounds 2a and 2e are better antibacterial agent compared to Gentamicin and Tetracycline.
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DOI: 10.5155/eurjchem.3.4.406-410.476
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Funding information
Rajiv Gandhi fellowship (Junior & Senior Research Fellowship, JRF & SRF (UGC)), N. Delhi, India and Department of Chemistry, Punjabi University, Patiala, India
Citations
[1]. Maysoon Mohammed Almahdi, Ahmed Elsadig Mohammed Saeed, Nadia Hanafy Metwally
Synthesis and antimicrobial activity of some new pyrazoline derivatives bearing sulfanilamido moiety
European Journal of Chemistry 10(1), 30, 2019
DOI: 10.5155/eurjchem.10.1.30-36.1791

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