European Journal of Chemistry 2012, 3(4), 406-410 | doi: https://doi.org/10.5155/eurjchem.3.4.406-410.476 | Get rights and content






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Synthesis and in-vitro antibacterial activity of some bis-5-(thiophen-2-yl)-carbothioamide-pyrazoline derivatives


Mamta Rani (1,*) , Mohamad Yusuf (2)

(1) Department of Chemistry, Punjabi University, Patiala, Punjab, 147002, India
(2) Department of Chemistry, Punjabi University, Patiala, Punjab, 147002, India
(*) Corresponding Author

Received: 08 Jun 2011 | Revised: 02 Sep 2011 | Accepted: 15 Sep 2011 | Published: 31 Dec 2012 | Issue Date: December 2012

Abstract


Five new compounds, bis-pyrazoline derivatives (2a-e) with antibacterial properties, built around the alkyl chains of varying lengths were prepared via reaction of various 1-ω-alkoxy-bis-chalcones with N-substituted thiosemicarbazide in ethanolic NaOH solution. The antibacterial activity of these compounds were evaluated by the disk diffusion method against two Gram-positive and two Gram-negative bacteria and the minimum inhibitory concentration were determined. The structures of these compounds were elucidated by IR, 1H-NMR, 13C-NMR, ESI mass spectrometry and their purities were also confirmed by elemental analyses. The formation and stereochemical features of the compounds, 2a-e, are found to be independent of the internal spacer length. The results showed that compounds 2a and 2e are better antibacterial agent compared to Gentamicin and Tetracycline.

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Keywords


Gentamicin; Tetracycline; Bis-chalcones; Bis-prazolines; Thiosemicarbazide; Antibacterial activity

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DOI: 10.5155/eurjchem.3.4.406-410.476

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Funding information


Rajiv Gandhi fellowship (Junior & Senior Research Fellowship, JRF & SRF (UGC)), N. Delhi, India and Department of Chemistry, Punjabi University, Patiala, India

Citations

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[1]. Maysoon Mohammed Almahdi, Ahmed Elsadig Mohammed Saeed, Nadia Hanafy Metwally
Synthesis and antimicrobial activity of some new pyrazoline derivatives bearing sulfanilamido moiety
European Journal of Chemistry  10(1), 30, 2019
DOI: 10.5155/eurjchem.10.1.30-36.1791
/


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How to cite


Rani, M.; Yusuf, M. Eur. J. Chem. 2012, 3(4), 406-410. doi:10.5155/eurjchem.3.4.406-410.476
Rani, M.; Yusuf, M. Synthesis and in-vitro antibacterial activity of some bis-5-(thiophen-2-yl)-carbothioamide-pyrazoline derivatives. Eur. J. Chem. 2012, 3(4), 406-410. doi:10.5155/eurjchem.3.4.406-410.476
Rani, M., & Yusuf, M. (2012). Synthesis and in-vitro antibacterial activity of some bis-5-(thiophen-2-yl)-carbothioamide-pyrazoline derivatives. European Journal of Chemistry, 3(4), 406-410. doi:10.5155/eurjchem.3.4.406-410.476
Rani, Mamta, & Mohamad Yusuf. "Synthesis and in-vitro antibacterial activity of some bis-5-(thiophen-2-yl)-carbothioamide-pyrazoline derivatives." European Journal of Chemistry [Online], 3.4 (2012): 406-410. Web. 26 May. 2020
Rani, Mamta, AND Yusuf, Mohamad. "Synthesis and in-vitro antibacterial activity of some bis-5-(thiophen-2-yl)-carbothioamide-pyrazoline derivatives" European Journal of Chemistry [Online], Volume 3 Number 4 (31 December 2012)

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DOI Link: https://doi.org/10.5155/eurjchem.3.4.406-410.476

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