European Journal of Chemistry

Synthesis and in-vitro antibacterial activity of some bis-5-(thiophen-2-yl)-carbothioamide-pyrazoline derivatives



Main Article Content

Mamta Rani
Mohamad Yusuf

Abstract

Five new compounds, bis-pyrazoline derivatives (2a-e) with antibacterial properties, built around the alkyl chains of varying lengths were prepared via reaction of various 1-ω-alkoxy-bis-chalcones with N-substituted thiosemicarbazide in ethanolic NaOH solution. The antibacterial activity of these compounds were evaluated by the disk diffusion method against two Gram-positive and two Gram-negative bacteria and the minimum inhibitory concentration were determined. The structures of these compounds were elucidated by IR, 1H-NMR, 13C-NMR, ESI mass spectrometry and their purities were also confirmed by elemental analyses. The formation and stereochemical features of the compounds, 2a-e, are found to be independent of the internal spacer length. The results showed that compounds 2a and 2e are better antibacterial agent compared to Gentamicin and Tetracycline.

3_4_406_410_800


icon graph This Abstract was viewed 1337 times | icon graph Article PDF downloaded 991 times

How to Cite
(1)
Rani, M.; Yusuf, M. Synthesis and in-Vitro Antibacterial Activity of Some Bis-5-(thiophen-2-Yl)-Carbothioamide-Pyrazoline Derivatives. Eur. J. Chem. 2012, 3, 406-410.

Article Details

Share
Crossref - Scopus - Google - European PMC
References

[1]. World Health Organization (WHO). "Guidelines for drinking-water quality", First Addendum to third edition, Geneva, 2006, 1,

[2]. Levai, A. Chem. Heterocyclic Compd. 1997, 33, 647-659.
http://dx.doi.org/10.1007/BF02291794

[3]. Ozdemir, Z; Kandilli, B.; Gumus, B. Euro. J. Med. Chem. 2007, 42, 309-315.

[4]. Brzozwski, Z.; Czewski, F. S.; Gdaniec, M. Euro. J. Med. Chem. 2000, 35, 1053-1064.
http://dx.doi.org/10.1016/S0223-5234(00)01194-6

[5]. Turan-Zitouni, G.; Ozdemir, A.; Guven, K. Arch. Pharm. 2005, 338, 96-104.
http://dx.doi.org/10.1002/ardp.200400935
PMid:15765490

[6]. Turan-Zitouni, G.; Ozdemir, A.; Kaplancikli, Z. A.; Chevallet P, Tunalı, Y. Phosphorus Sulfur 2005, 180, 2717-2724.
http://dx.doi.org/10.1080/104265090930452

[7]. Ozdemir, A.; Turan-Zitouni, G.; Kaplancikili, Z. A.; Revial, G.; Guven, K. Eur. J. Med. Chem. 2007, 42, 403-409.
http://dx.doi.org/10.1016/j.ejmech.2006.10.001
PMid:17125888

[8]. Shaharyar, M.; Siddiqui, A. A.; Ali, M. A.; Sriram, D.; Yogeeswari, P. Bioorg. Med. Chem. Lett. 2006, 16, 3947-3949.
http://dx.doi.org/10.1016/j.bmcl.2006.05.024
PMid:16725324

[9]. Nugent, R. A.; Murphy, M.; Schlachter, S. T.; Dunn, C. J.; Smith, R. J.; Staite, N. D.; Galinet, L. A.; Shields, S. K.; Aspar, D. G.; Richard, K. A.; Rohloff, N. A. J. Med. Chem. 1993, 36, 134-139.
http://dx.doi.org/10.1021/jm00053a017

[10]. Manna, F.; Chimenti, F.; Bolasco, A.; Cenicola, M. L.; D'Amico, M. Parrillo, C.; Rossi, F.; Marmo, E. Eur. J. Med. Chem. 1992, 27, 633-639.
http://dx.doi.org/10.1016/0223-5234(92)90142-N

[11]. Bazzanini, M.; Giovanni, B.; Pier, R.; Mario, G.; Daniele, S.; Maria, E. M.; Akssandra, P.; Enzo, T.; Paolo, C. J. Med. Chem. 1992, 35, 917-924.
http://dx.doi.org/10.1021/jm00083a017

[12]. Chetan, B. P.; Sreenivas, M. T.; Bhat, A. R. Ind. J. Heterocyclic Chem. 2004, 13, 225-228.

[13]. Bilgin, A. A.; Palaska, E.; Sunal, R. Arzneim. Forsch. Drug Res. 1993, 43, 1041-1044.

[14]. Bilgin, A. A.; Palaska, E.; Sunal, R.; Gumusel, B. Pharmazie 1994, 49, 67-69.
PMid:8140135

[15]. Raiford, L. C.; Peterson, W. J. J. Org. Chem. 1937, 1, 544-551.
http://dx.doi.org/10.1021/jo01235a003

[16]. Rani, M.; Yusuf, M. Eur. J. Chem. 2012, 3(1), 21-25.
http://dx.doi.org/10.5155/eurjchem.3.1.21-25.472

[17]. Khan, S. A.; Yusuf, M. Eur. J. Med. Chem. 2009, 44, 2270-2274.
http://dx.doi.org/10.1016/j.ejmech.2008.06.008
PMid:18715679

[18]. Husain, K.; Abid, M.; Azam A. Eur. J. Med. Chem. 2008, 43, 393-403.
http://dx.doi.org/10.1016/j.ejmech.2007.03.021
PMid:17513021

[19]. Khan, S. A.; Yusuf, M. Eur. J. Med. Chem. 2009, 44, 2597-2600.
http://dx.doi.org/10.1016/j.ejmech.2008.09.004
PMid:19211172

[20]. Bhat, A. R.; Athar, F.; Amir, A. Eur. J. Med. Chem. 2009, 44, 426-431.
http://dx.doi.org/10.1016/j.ejmech.2007.11.005
PMid:18187238

[21]. Bauer, A. W.; Kirby, W. M. M.; Sherris, J. C.; Truck, M. Am. J. Clin. Pathol. 1966, 36, 493-496.

Supporting Agencies

Rajiv Gandhi fellowship (Junior & Senior Research Fellowship, JRF & SRF (UGC)), N. Delhi, India and Department of Chemistry, Punjabi University, Patiala, India
TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).