European Journal of Chemistry 2012, 3(1), 94-98. doi:10.5155/eurjchem.3.1.94-98.523

Conventional and microwave assisted synthesis of 2-amino-4,6-diaryl pyrimidine derivatives and their cytotoxic, anti-oxidant activities


Mohammed Rayees Ahmad (1,*) , Vedula Girija Sastry (2) , Yejella Rajendra Prasad (3) , Mohammed Haseebur Rahman Khan (4) , Nasreen Bano (5) , Syed Anwar (6)

(1) Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, 530003, India
(2) Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, 530003, India
(3) Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, 530003, India
(4) Department of Pharmaceutical Chemistry, Shadan College of Pharmacy, Hyderabad, Andhra Pradesh, 500008, India
(5) Department of Pharmaceutical Chemistry, Shadan College of Pharmacy, Hyderabad, Andhra Pradesh, 500008, India
(6) Center for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad, Andhra Pradesh, 500085, India
(*) Corresponding Author

Received: 06 Sep 2011, Accepted: 13 Nov 2011, Published: 31 Mar 2012

Abstract


Pyrimidine is the parent substance of a large group of heterocyclic compounds and plays a vital role in many biological processes. It is also evident from literature; pyrimidines possess potential anti oxidant activities and cytotoxic activities. Chemoprotection by pyrimidines may be a consequence of their antioxidant properties, mediated via inhibition or induction of metabolic enzymes, by an anti-invasive effect or a reduction in nitric oxide production.  Free radicals are formed constantly in human system either as accidental products during metabolism or deliberately during the process of phagocytosis; or due to environmental pollutants, ionizing radiations, ozone, heavy metal poisoning, etc. Therefore, it is worthwhile to synthesize some pyrimidine derivatives by conventional and microwave (Catalyst systems) assisted synthesis methods. The synthesized compounds were purified by recrystallization or by chromatography and are characterized by 1H NMR, 13C NMR and IR analysis. The compounds were tested for their potential cytotoxic activity and antioxidant activities by standard methods. The microwave irradiation method (MWI) is proved to be advantageous with considerable increase in the reaction rate with better yields, after over all observation it is found  that pyrimidine derivatives possessing cytotoxic and anti-oxidant activities.

3_1_94_98_800


Keywords


Chalcones; Pyrimidines; Cytotoxic activity; Microwave assisted; Coventional method; Antioxidant activity

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DOI: 10.5155/eurjchem.3.1.94-98.523

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New pyrimidine-based photo-switchable bent-core liquid crystals
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[2]. Ahmed A. El-Barbary, Ashraf A. El-Shehawy, Nabiha I. Abdo
Synthesis and Antimicrobial Activities of Some 6-Methyl-3-Thioxo-2,3-Dihydro-1,2,4-Triazine Derivatives
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[3]. Shiwani Shukla, Dinesh Kumar, Ritu Ojha, Manish K. Gupta, Kunal Nepali, Preet M. S. Bedi
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How to cite


Ahmad, M.; Sastry, V.; Prasad, Y.; Khan, M.; Bano, N.; Anwar, S. Eur. J. Chem. 2012, 3(1), 94-98. doi:10.5155/eurjchem.3.1.94-98.523
Ahmad, M.; Sastry, V.; Prasad, Y.; Khan, M.; Bano, N.; Anwar, S. Conventional and microwave assisted synthesis of 2-amino-4,6-diaryl pyrimidine derivatives and their cytotoxic, anti-oxidant activities. Eur. J. Chem. 2012, 3(1), 94-98. doi:10.5155/eurjchem.3.1.94-98.523
Ahmad, M., Sastry, V., Prasad, Y., Khan, M., Bano, N., & Anwar, S. (2012). Conventional and microwave assisted synthesis of 2-amino-4,6-diaryl pyrimidine derivatives and their cytotoxic, anti-oxidant activities. European Journal of Chemistry, 3(1), 94-98. doi:10.5155/eurjchem.3.1.94-98.523
Ahmad, Mohammed, Vedula Girija Sastry, Yejella Rajendra Prasad, Mohammed Haseebur Rahman Khan, Nasreen Bano, & Syed Anwar. "Conventional and microwave assisted synthesis of 2-amino-4,6-diaryl pyrimidine derivatives and their cytotoxic, anti-oxidant activities." European Journal of Chemistry [Online], 3.1 (2012): 94-98. Web. 16 Sep. 2019
Ahmad, Mohammed, Sastry, Vedula, Prasad, Yejella, Khan, Mohammed, Bano, Nasreen, AND Anwar, Syed. "Conventional and microwave assisted synthesis of 2-amino-4,6-diaryl pyrimidine derivatives and their cytotoxic, anti-oxidant activities" European Journal of Chemistry [Online], Volume 3 Number 1 (31 March 2012)

DOI Link: https://doi.org/10.5155/eurjchem.3.1.94-98.523

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