

Conventional and microwave assisted synthesis of 2-amino-4,6-diaryl pyrimidine derivatives and their cytotoxic, anti-oxidant activities
Mohammed Rayees Ahmad (1,*)






(1) Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, 530003, India
(2) Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, 530003, India
(3) Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, 530003, India
(4) Department of Pharmaceutical Chemistry, Shadan College of Pharmacy, Hyderabad, Andhra Pradesh, 500008, India
(5) Department of Pharmaceutical Chemistry, Shadan College of Pharmacy, Hyderabad, Andhra Pradesh, 500008, India
(6) Center for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad, Andhra Pradesh, 500085, India
(*) Corresponding Author
Received: 06 Sep 2011 | Revised: 12 Oct 2011 | Accepted: 13 Nov 2011 | Published: 31 Mar 2012 | Issue Date: March 2012
Abstract
Pyrimidine is the parent substance of a large group of heterocyclic compounds and plays a vital role in many biological processes. It is also evident from literature; pyrimidines possess potential anti oxidant activities and cytotoxic activities. Chemoprotection by pyrimidines may be a consequence of their antioxidant properties, mediated via inhibition or induction of metabolic enzymes, by an anti-invasive effect or a reduction in nitric oxide production. Free radicals are formed constantly in human system either as accidental products during metabolism or deliberately during the process of phagocytosis; or due to environmental pollutants, ionizing radiations, ozone, heavy metal poisoning, etc. Therefore, it is worthwhile to synthesize some pyrimidine derivatives by conventional and microwave (Catalyst systems) assisted synthesis methods. The synthesized compounds were purified by recrystallization or by chromatography and are characterized by 1H NMR, 13C NMR and IR analysis. The compounds were tested for their potential cytotoxic activity and antioxidant activities by standard methods. The microwave irradiation method (MWI) is proved to be advantageous with considerable increase in the reaction rate with better yields, after over all observation it is found that pyrimidine derivatives possessing cytotoxic and anti-oxidant activities.
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DOI: 10.5155/eurjchem.3.1.94-98.523
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Citations
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One‐pot and two‐pot methods for chalcone derived pyrimidines synthesis and applications
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DOI: 10.1002/jhet.4226

[2]. Md Lutfor Rahman, Gurumurthy Hegde, Mashitah Mohd Yusoff, Muhammad Nor Fazli A. Malek, Hosapalya T. Srinivasa, Sandeep Kumar
New pyrimidine-based photo-switchable bent-core liquid crystals
New Journal of Chemistry 37(8), 2460, 2013
DOI: 10.1039/c3nj00359k

[3]. Ahmed A. El-Barbary, Ashraf A. El-Shehawy, Nabiha I. Abdo
Synthesis and Antimicrobial Activities of Some 6-Methyl-3-Thioxo-2,3-Dihydro-1,2,4-Triazine Derivatives
Phosphorus, Sulfur, and Silicon and the Related Elements 189(3), 400, 2014
DOI: 10.1080/10426507.2012.755972

[4]. Shiwani Shukla, Dinesh Kumar, Ritu Ojha, Manish K. Gupta, Kunal Nepali, Preet M. S. Bedi
4,6-Diaryl/heteroarylpyrimidin-2(1H)-ones as a New Class of Xanthine Oxidase Inhibitors
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DOI: 10.1002/ardp.201400031

[5]. Biswa Mohan Sahoo, Bimal Krishna Banik, Bera Venkata Varaha Ravi Kumar, Krishna Chandra Panda, Abhishek Tiwari, Varsha Tiwari, Sunil Singh, Manish Kumar
Microwave Induced Green Synthesis: Sustainable Technology for Efficient Development of Bioactive Pyrimidine Scaffolds
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DOI: 10.2174/0929867329666220622150013

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