European Journal of Chemistry 2012, 3(1), 94-98 | doi: https://doi.org/10.5155/eurjchem.3.1.94-98.523 | Get rights and content

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Conventional and microwave assisted synthesis of 2-amino-4,6-diaryl pyrimidine derivatives and their cytotoxic, anti-oxidant activities


Mohammed Rayees Ahmad (1,*) , Vedula Girija Sastry (2) , Yejella Rajendra Prasad (3) , Mohammed Haseebur Rahman Khan (4) , Nasreen Bano (5) , Syed Anwar (6)

(1) Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, 530003, India
(2) Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, 530003, India
(3) Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, 530003, India
(4) Department of Pharmaceutical Chemistry, Shadan College of Pharmacy, Hyderabad, Andhra Pradesh, 500008, India
(5) Department of Pharmaceutical Chemistry, Shadan College of Pharmacy, Hyderabad, Andhra Pradesh, 500008, India
(6) Center for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad, Andhra Pradesh, 500085, India
(*) Corresponding Author

Received: 06 Sep 2011 | Revised: 12 Oct 2011 | Accepted: 13 Nov 2011 | Published: 31 Mar 2012 | Issue Date: March 2012

Abstract


Pyrimidine is the parent substance of a large group of heterocyclic compounds and plays a vital role in many biological processes. It is also evident from literature; pyrimidines possess potential anti oxidant activities and cytotoxic activities. Chemoprotection by pyrimidines may be a consequence of their antioxidant properties, mediated via inhibition or induction of metabolic enzymes, by an anti-invasive effect or a reduction in nitric oxide production.  Free radicals are formed constantly in human system either as accidental products during metabolism or deliberately during the process of phagocytosis; or due to environmental pollutants, ionizing radiations, ozone, heavy metal poisoning, etc. Therefore, it is worthwhile to synthesize some pyrimidine derivatives by conventional and microwave (Catalyst systems) assisted synthesis methods. The synthesized compounds were purified by recrystallization or by chromatography and are characterized by 1H NMR, 13C NMR and IR analysis. The compounds were tested for their potential cytotoxic activity and antioxidant activities by standard methods. The microwave irradiation method (MWI) is proved to be advantageous with considerable increase in the reaction rate with better yields, after over all observation it is found  that pyrimidine derivatives possessing cytotoxic and anti-oxidant activities.

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Editor-in-Chief
European Journal of Chemistry

Keywords


Chalcones; Pyrimidines; Cytotoxic activity; Microwave assisted; Coventional method; Antioxidant activity

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DOI: 10.5155/eurjchem.3.1.94-98.523

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Citations

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[1]. Saba Farooq, Zainab Ngaini
One‐pot and two‐pot methods for chalcone derived pyrimidines synthesis and applications
Journal of Heterocyclic Chemistry  58(6), 1209, 2021
DOI: 10.1002/jhet.4226
/


[2]. Md Lutfor Rahman, Gurumurthy Hegde, Mashitah Mohd Yusoff, Muhammad Nor Fazli A. Malek, Hosapalya T. Srinivasa, Sandeep Kumar
New pyrimidine-based photo-switchable bent-core liquid crystals
New Journal of Chemistry  37(8), 2460, 2013
DOI: 10.1039/c3nj00359k
/


[3]. Ahmed A. El-Barbary, Ashraf A. El-Shehawy, Nabiha I. Abdo
Synthesis and Antimicrobial Activities of Some 6-Methyl-3-Thioxo-2,3-Dihydro-1,2,4-Triazine Derivatives
Phosphorus, Sulfur, and Silicon and the Related Elements  189(3), 400, 2014
DOI: 10.1080/10426507.2012.755972
/


[4]. Shiwani Shukla, Dinesh Kumar, Ritu Ojha, Manish K. Gupta, Kunal Nepali, Preet M. S. Bedi
4,6-Diaryl/heteroarylpyrimidin-2(1H)-ones as a New Class of Xanthine Oxidase Inhibitors
Archiv der Pharmazie  347(7), 486, 2014
DOI: 10.1002/ardp.201400031
/


[5]. Biswa Mohan Sahoo, Bimal Krishna Banik, Bera Venkata Varaha Ravi Kumar, Krishna Chandra Panda, Abhishek Tiwari, Varsha Tiwari, Sunil Singh, Manish Kumar
Microwave Induced Green Synthesis: Sustainable Technology for Efficient Development of Bioactive Pyrimidine Scaffolds
Current Medicinal Chemistry  30(9), 1029, 2023
DOI: 10.2174/0929867329666220622150013
/


References


[1]. Kidwai, M.; Saxena, S.; Rastogi, S.; Venkataramanan, R. Anti-Infect. Agents Med Chem. 2003, 2(4), 269-286.
http://dx.doi.org/10.2174/1568012033483015

[2]. Shah, V. H.; Trivedi, A. R.; Dodiya, D. K.; Ravat, N. R. Arkivoc 2008, 11, 131-141.

[3]. Kamal, A.; Reddy, K. L.; Devaiah, V.; Shankaraiah, N.; Kumar, M. S.; Reddy, G. S. K. Lett. Drug Des. Discovery 2005, 2, 55-61.
http://dx.doi.org/10.2174/1570180053398343

[4]. Huang, J.; Li, H.; Li, J.; Jiang, H.; Zhu, J.; Chen, T.; Liu, J. Molecules 2009, 14, 785-797.
http://dx.doi.org/10.3390/molecules14020785
PMid:19223827

[5]. Kau, B.; Pathak, P.; Kaur, R. Arkivoc 2006, 6, 160-171.

[6]. Narule, M. N.; Meshram, J. S. Int. J. Chem. Sci. 2007, 5(1), 310-318.

[7]. Amir, M.; Aggrawal, R.; Javed, S. A. Orient. J Chem. 2004, 20(3), 477-480.

[8]. Singh, P.; Kaur, J.; Paul, K. Indian J. Chem. 2008, 47B, 291-296.

[9]. Sondhi, S. M.; Jain, S.; Dwivedi, A. D.; Shukla, R.; Raghubir, R. Indian J. Chem. 2008, 47B, 136-143.

[10]. Desai. K. R.; Chikhalia, K. H.; Patel, R. B.; Desai, P. S. Indian J. Chem. 2006, 45B, 773-778.

[11]. Sondhi, S. M.; Dinodia, M.; Rani, R.; Shukla, R.; Raghubir, R. Indian. J. Chem. 2009, 49B, 273-281.

[12]. Brown, D. J. Rev. Pure Appl. Chem. 1953, 3, 115-116.

[13]. Brown, D. J. The pyridines, A. Weissberger, Interscience, New York, 1962, pp. 183-210.

[14]. Reddy, C. S.; Nagaraj, A. J. Heterocyclic. Chem, 2007, 44(5), 1181-1185.
http://dx.doi.org/10.1002/jhet.5570440534

[15]. Suryawanshi, S. N.; Bhat, B. A.; Susmita, P.; Naveen, C.; Suman, G. Eur. J. Med. Chem. 2007, 42, 1211-1217.
http://dx.doi.org/10.1016/j.ejmech.2006.10.002
PMid:17499393

[16]. Sunduru, N.; Agarwal, A.; Katiyar, S. B.; Nishi; Goyal, N.; Gupta, S.; Chauhan, P. M. S. Bioorg. Med. Chem. 2006, 14, 7706-7715.
http://dx.doi.org/10.1016/j.bmc.2006.08.009

[17]. Akbar, M.; Naser, F.; Golnar, K.; Neda, F. Synth. React. Inorg., Met.-Org., Nano-Met. Chem 2007, 37, 279-282.

[18]. Shujang, T.; Fung, F.; Chunbao, M.; Hong, J.; Youjian, F.; Daqing S.; Xiangshan, W. Tetrahedron Lett. 2003, 44, 6153-6156.
http://dx.doi.org/10.1016/S0040-4039(03)01466-7

[19]. Meyer, B. N.; Ferringi, N. R.; Putnam, J. E.; Jacobsen, L. B.; Nicholas, D.; McLaughlin, J. L. Planta Med. 1982, 45, 31-34.
http://dx.doi.org/10.1055/s-2007-971236
PMid:17396775

[20]. Michael, A. S., Thompson, C. G.; Abramovitz, M. Science 1956, 123, 464-464.
http://dx.doi.org/10.1126/science.123.3194.464
PMid:17775415

[21]. Vanhaeke, P.; Persoone, G.; Claus, C.; Sorgeloos, P. Ecotoxicol. Environ. Saf. 1981, 5, 382-387.
http://dx.doi.org/10.1016/0147-6513(81)90012-9

[22]. Harwing, J.; Scott, P. Appl. Microbiol. 1971, 21, 1011-1016.
PMid:5105681 PMCid:377334

[23]. McLaughlin, J. L.; Chang, C. J.; Smith, D. L. American Chemical Society Symp. Series 534, Am. Chem. Soc. Washington, D. C, 1993, 112-137.

[24]. Sleet, R. B.; Brendel, K. Ecotoxicol. Environ. Saf. 1983, 7, 435-446.
http://dx.doi.org/10.1016/0147-6513(83)90082-9

[25]. Lamaison, J. L.; Ptitjean-Freytet, C.; Carnet, A. Pharm. Acta Helv. 1991, 66, 185-188.
PMid:1763093


How to cite


Ahmad, M.; Sastry, V.; Prasad, Y.; Khan, M.; Bano, N.; Anwar, S. Eur. J. Chem. 2012, 3(1), 94-98. doi:10.5155/eurjchem.3.1.94-98.523
Ahmad, M.; Sastry, V.; Prasad, Y.; Khan, M.; Bano, N.; Anwar, S. Conventional and microwave assisted synthesis of 2-amino-4,6-diaryl pyrimidine derivatives and their cytotoxic, anti-oxidant activities. Eur. J. Chem. 2012, 3(1), 94-98. doi:10.5155/eurjchem.3.1.94-98.523
Ahmad, M., Sastry, V., Prasad, Y., Khan, M., Bano, N., & Anwar, S. (2012). Conventional and microwave assisted synthesis of 2-amino-4,6-diaryl pyrimidine derivatives and their cytotoxic, anti-oxidant activities. European Journal of Chemistry, 3(1), 94-98. doi:10.5155/eurjchem.3.1.94-98.523
Ahmad, Mohammed, Vedula Girija Sastry, Yejella Rajendra Prasad, Mohammed Haseebur Rahman Khan, Nasreen Bano, & Syed Anwar. "Conventional and microwave assisted synthesis of 2-amino-4,6-diaryl pyrimidine derivatives and their cytotoxic, anti-oxidant activities." European Journal of Chemistry [Online], 3.1 (2012): 94-98. Web. 28 Sep. 2023
Ahmad, Mohammed, Sastry, Vedula, Prasad, Yejella, Khan, Mohammed, Bano, Nasreen, AND Anwar, Syed. "Conventional and microwave assisted synthesis of 2-amino-4,6-diaryl pyrimidine derivatives and their cytotoxic, anti-oxidant activities" European Journal of Chemistry [Online], Volume 3 Number 1 (31 March 2012)

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