European Journal of Chemistry 2012, 3(2), 186-190. doi:10.5155/eurjchem.3.2.186-190.554

A comparative study on synthesis of some novel α,β-unsaturated carbonyl derivatives and their antioxidant potential


Mohammed Rayees Ahmad (1,*) , Mohammed Haseebur Rahman Khan (2) , Vedula Girija Sastry (3) , Nasreen Bano (4) , Syed Anwar (5) , Yejella Rajendra Prasad (6)

(1) Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, 530003, India
(2) Department of Pharmaceutical Chemistry, Shadan College of Pharmacy, Hyderabad, Andhra Pradesh, 500008, India
(3) Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, 530003, India
(4) Center for Biotechnology, Jawaharlal Nehru Technological University, Hyderabad, Andhra Pradesh, 500085, India
(5) Analytical Research and Development Department, Wockhardt Research Center, Aurangabad, Maharashtra, 431201, India
(6) Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, 530003, India
(*) Corresponding Author

Received: 25 Nov 2011, Accepted: 20 Jan 2012, Published: 30 Jun 2012

Abstract


Free radicals are constantly formed in human system either as accidental products during metabolism or deliberately during the process of phagocytosis or due to environmental pollutants, ionizing radiations, ozone, heavy metal poisoning, etc. It is found from literature survey that chalcones (α,β-unsaturated carbonyl derivatives) exhibit great antioxidant activity. Hence, the synthesis of some new chalcone derivatives was undertaken and were synthesized by two methods namely, conventional and microwave irradiation methods. The synthesized chalcone derivatives were tested for their in vitro antioxidant activity by using NBT-superoxide free-radical scavenging activity and DPPH radical scavenging activity. The potency of the chalcone derivatives was estimated by IC50 values and they have shown promising antioxidant activity. Among all the chalcones synthesized, derivative 3e showed maximum superoxide inhibition as per NBT method and all the derivatives have shown different percentage inhibitions at different concentrations as per  DPPH method. The compounds were characterized by 1H NMR and IR spectral analysis.

3_2_186_190_800


Keywords


Chalcones; Conventional method; Microwave irradiation; Radical scavenging activity; Potential antioxidant activity; Claisen-Schmidt condensation

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DOI: 10.5155/eurjchem.3.2.186-190.554

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Citations

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[1]. Rafael E. Rodríguez-Lugo, Neudo Urdaneta, Bruno Pribanic, Vanessa R. Landaeta
The solid-state emmissive chalcone (2E)-1-(5-chlorothiophen-2-yl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one
Acta Crystallographica Section C Structural Chemistry  71(9), 783, 2015
DOI: 10.1107/S2053229615014205
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[2]. Bharat Kumar Bugata, Satya Venkata Gopala Kaladhar Dowluru, Vasudeva Rao Avupati, Venkateswara Rao Gavalapu, Divakara Laxman Somayajulu Nori, Sreenu Barla
Synthesis, characterization and in vitro biological evaluation of some new diarylsulfonylurea-chalcone hybrids as potential 5-lipoxygenase inhibitors
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[3]. Divakara Laxman Somayajulu Nori, Kasapu Vishnu Veera Venkata Satyanarayan, Vasudeva Rao Avupati, Bharat Kumar Bugata, Subhash Yenupuri
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[4]. Farouq Emam Hawaiz, Awaz Jamil Hussein, Mohammed Kareem Samad
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How to cite


Ahmad, M.; Khan, M.; Sastry, V.; Bano, N.; Anwar, S.; Prasad, Y. Eur. J. Chem. 2012, 3(2), 186-190. doi:10.5155/eurjchem.3.2.186-190.554
Ahmad, M.; Khan, M.; Sastry, V.; Bano, N.; Anwar, S.; Prasad, Y. A comparative study on synthesis of some novel α,β-unsaturated carbonyl derivatives and their antioxidant potential. Eur. J. Chem. 2012, 3(2), 186-190. doi:10.5155/eurjchem.3.2.186-190.554
Ahmad, M., Khan, M., Sastry, V., Bano, N., Anwar, S., & Prasad, Y. (2012). A comparative study on synthesis of some novel α,β-unsaturated carbonyl derivatives and their antioxidant potential. European Journal of Chemistry, 3(2), 186-190. doi:10.5155/eurjchem.3.2.186-190.554
Ahmad, Mohammed, Mohammed Haseebur Rahman Khan, Vedula Girija Sastry, Nasreen Bano, Syed Anwar, & Yejella Rajendra Prasad. "A comparative study on synthesis of some novel α,β-unsaturated carbonyl derivatives and their antioxidant potential." European Journal of Chemistry [Online], 3.2 (2012): 186-190. Web. 13 Nov. 2019
Ahmad, Mohammed, Khan, Mohammed, Sastry, Vedula, Bano, Nasreen, Anwar, Syed, AND Prasad, Yejella. "A comparative study on synthesis of some novel α,β-unsaturated carbonyl derivatives and their antioxidant potential" European Journal of Chemistry [Online], Volume 3 Number 2 (30 June 2012)

DOI Link: https://doi.org/10.5155/eurjchem.3.2.186-190.554

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