European Journal of Chemistry 2012, 3(2), 143-146. doi:10.5155/eurjchem.3.2.143-146.551

Microwave-assisted solvent free efficient synthesis of 1,3,4-oxadiazole-2(3H)-thiones and their potent in vitro urease inhibition activity


Sohail Anjum Shahzad (1,*) , Muhammad Yar (2) , Zulfiqar Ali Khan (3) , Islam Ullah Khan (4) , Syed Ali Raza Naqvi (5) , Nasir Mahmood (6) , Khalid Mohammed Khan (7)

(1) Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad, 22060, Pakistan
(2) Interdisciplinary Research Center in Biomedical Materials, COMSATS Institute of Information Technology, Lahore, 54000, Pakistan
(3) Department of Chemistry, Government College University, Faisalabad, 38000, Pakistan
(4) Department of Chemistry, Government College University, Lahore, 54000, Pakistan
(5) Department of Chemistry, Government College University, Faisalabad, 38000, Pakistan
(6) Department of Allied Sciences and Chemical Pathology, University of Health Sciences, Lahore, 54600, Pakistan
(7) Hussain Ibrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan
(*) Corresponding Author

Received: 18 Nov 2011, Accepted: 03 Feb 2012, Published: 30 Jun 2012

Abstract


An efficient solvent free microwave assisted synthesis of 5-substituted-1,3,4-oxadiazole-2(3H)-thiones (2a-2r) from hydrazides and carbon disulfide has been accomplished in good to excellent yield. The urease inhibition activity of the resulting compounds was investigated. Preliminary bioassay indicated that the compound 2j bearing 2-bromo substituent is the most active inhibitor exhibiting IC50 12.60 ± 0.92 μM.

3_2_143_146_800


Keywords


High yield; Hydrazides; Solvent free; Urease inhibition; Microwave-irradiation; Substituted-1,3,4-oxadiazole

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DOI: 10.5155/eurjchem.3.2.143-146.551

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How to cite


Shahzad, S.; Yar, M.; Khan, Z.; Khan, I.; Naqvi, S.; Mahmood, N.; Khan, K. Eur. J. Chem. 2012, 3(2), 143-146. doi:10.5155/eurjchem.3.2.143-146.551
Shahzad, S.; Yar, M.; Khan, Z.; Khan, I.; Naqvi, S.; Mahmood, N.; Khan, K. Microwave-assisted solvent free efficient synthesis of 1,3,4-oxadiazole-2(3H)-thiones and their potent in vitro urease inhibition activity. Eur. J. Chem. 2012, 3(2), 143-146. doi:10.5155/eurjchem.3.2.143-146.551
Shahzad, S., Yar, M., Khan, Z., Khan, I., Naqvi, S., Mahmood, N., & Khan, K. (2012). Microwave-assisted solvent free efficient synthesis of 1,3,4-oxadiazole-2(3H)-thiones and their potent in vitro urease inhibition activity. European Journal of Chemistry, 3(2), 143-146. doi:10.5155/eurjchem.3.2.143-146.551
Shahzad, Sohail, Muhammad Yar, Zulfiqar Ali Khan, Islam Ullah Khan, Syed Ali Raza Naqvi, Nasir Mahmood, & Khalid Mohammed Khan. "Microwave-assisted solvent free efficient synthesis of 1,3,4-oxadiazole-2(3H)-thiones and their potent in vitro urease inhibition activity." European Journal of Chemistry [Online], 3.2 (2012): 143-146. Web. 17 Sep. 2019
Shahzad, Sohail, Yar, Muhammad, Khan, Zulfiqar, Khan, Islam, Naqvi, Syed, Mahmood, Nasir, AND Khan, Khalid. "Microwave-assisted solvent free efficient synthesis of 1,3,4-oxadiazole-2(3H)-thiones and their potent in vitro urease inhibition activity" European Journal of Chemistry [Online], Volume 3 Number 2 (30 June 2012)

DOI Link: https://doi.org/10.5155/eurjchem.3.2.143-146.551

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