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Novel indole-2-carboxylic acid analogues: Synthesis and a new light in to their antioxidant potentials
Nagaraja Naik (1,*)
, Vishwanath Sharath (2) , Honnaiah Vijay Kumar (3) (1) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570006, Karnataka, India
(2) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570006, Karnataka, India
(3) Department of Organic Chemistry, Indian Institute of Science, Bangalore, 560012, India
(*) Corresponding Author
Received: 14 Jan 2012 | Revised: 20 Feb 2012 | Accepted: 21 Feb 2012 | Published: 30 Jun 2012 | Issue Date: June 2012
Abstract
Two series of novel indole-2-carboxylic acid derivatives is reported. In the first series, N-substituted derivatives (3a-h) were synthesized via acylation of indole-2-carboxylic acid followed by aldol condensation reaction. Whereas, in the second series, indole-2-carboxamides (5a-g) were synthesized through conversion of acid to its acid chloride followed by coupling of substituted anilines. Structures of the newly synthesized compounds were confirmed by elemental analysis and spectral IR, 1H NMR and mass data and were screened for antioxidant activity. Among the first series, compound 3g showed higher antioxidant activity and whereas, in the second series compounds 5b and 5c exhibited potential antioxidant activity. Compounds 3g, 5b and 5c exhibited for its enhanced antioxidant activity.
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.3.2.214-219.588
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Indian Institute of Science, Bangalore, India
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[2]. Fares Hezam Al-Ostoot, D.V. Geetha, Yasser Hussein Eissa Mohammed, P. Akhileshwari, M.A. Sridhar, Shaukath Ara Khanum
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[4]. Honnaiah Vijay Kumar, Prasanth Kumar, Javarappa Rangaswamy, Kirugunda Udayakumar Sindhu, Nagaraja Naik
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DOI Link: https://doi.org/10.5155/eurjchem.3.2.214-219.588
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European Journal of Chemistry 2012, 3(2), 214-219 | doi: https://doi.org/10.5155/eurjchem.3.2.214-219.588 | Get rights and content
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