

In-vitro cytotoxic and radiosensitizing evaluation of novel 2-pyridone, isoquinoline, chromene and chromenopyridone derivatives
Mansour Sulaiman Al-Said (1)



(1) Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia
(2) Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, 11371, Egypt
(3) Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia
(*) Corresponding Author
Received: 10 Feb 2012 | Revised: 16 Mar 2012 | Accepted: 28 Mar 2012 | Published: 30 Jun 2012 | Issue Date: June 2012
Abstract
On the account of the reported anticancer activity of 2-pyridone, a new series of ethyl-1,6-dihydropyridine-3-carboxylate (4a-j), 1-oxo-1,2-dihydroisoquinoline-7-carbonitrile (6a-h), 2H-chromene (7,8) and 3H-chromeno[3,4-c]pyridone derivatives (9,10) were synthesized and tested for in-vitro anticancer activity against Ehrlich Ascites Carcinoma (EAC) cell line and human liver cell line (HEPG2). The structures of the synthesized compounds were confirmed by analytical and spectral data. Furthermore, radiosensitization study was performed for the most potent compounds (4a, 4d, 6a, 6c, 6e and 10).
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.3.2.228-234.596
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The Research Center, College of Pharmacy and the Deanship of Scientific Research, King Saud University, Riyadh, Saudi Arabia
Citations
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DOI: 10.1021/acs.jmedchem.0c00939

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DOI: 10.1080/00397911.2014.903422

[5]. Mostafa Ghorab, Marwa El-Gazzar, Mansour Alsaid
Synthesis and Anti-Breast Cancer Evaluation of Novel N-(Guanidinyl)benzenesulfonamides
International Journal of Molecular Sciences 15(4), 5582, 2014
DOI: 10.3390/ijms15045582

[6]. Serda Kecel-Gunduz, Yasemin Budama-Kilinc, Bahar Gok, Bilge Bicak, Gizem Akman, Busra Arvas, Feray Aydogan, Cigdem Yolacan
Computer-aided anticancer drug design: In vitro and in silico studies of new iminocoumarin derivative
Journal of Molecular Structure 1239, 130539, 2021
DOI: 10.1016/j.molstruc.2021.130539

[7]. Shivaputra A Patil, Renukadevi Patil, Lawrence M Pfeffer, Duane D Miller
Chromenes: potential new chemotherapeutic agents for cancer
Future Medicinal Chemistry 5(14), 1647, 2013
DOI: 10.4155/fmc.13.126

[8]. Pintu Kumar Mandal
Copper-catalyzed one-pot synthesis of glycosylated iminocoumarins and 3-triazolyl-2-iminocoumarins
RSC Advances 4(11), 5803, 2014
DOI: 10.1039/c3ra46844e

References
[1]. Abadi, A. H.; Ibrahim, T. M.; Abouzid, K. M.; Lehmann. J.; Tinsley, H. N.; Gary, B. D.; Piazza, G. A. Bioorg. Med. Chem. 2009, 17, 5974-5982.
http://dx.doi.org/10.1016/j.bmc.2009.06.063
[2]. Cheney, I. W.; Yan, S.; Appleby, T.; Walker, H.; Vo, T.; Yao, N.; Hamatake, R.; Hong, Z.; Wu, J. Z. Bioorg. Med. Chem. Lett. 2007, 17, 1679-1683.
http://dx.doi.org/10.1016/j.bmcl.2006.12.086
[3]. Wendt, M. D.; Sun, C.; Kunzer, A.; Sauer, D.; Sarris, K.; Hoff, E.; Yu, L.; Nettesheim, D. G.; Chen, J.; Jin, S.; Comess, K. M.; Fan, Y.; Anderson, S. N.; Isaac, B.; Olejniczak, E. T.; Hajduk, P. J.; Rosenberg, S. H.; Elmore, S. W. Bioorg. Med. Chem. Lett. 2007, 17, 3122-3129.
http://dx.doi.org/10.1016/j.bmcl.2007.03.042
[4]. Aqui, N. A.; Vonderheide, R. H. Cancer Biol. Ther. 2008, 7, 1888-1889.
http://dx.doi.org/10.4161/cbt.7.12.7219
[5]. Ambrosini, G.; Adida, C.; Altieri, D. C. Nat. Med. 1997, 3, 917-921.
http://dx.doi.org/10.1038/nm0897-917
PMid:9256286
[6]. Gary, P.; Soh, J. W.; Mao, Y.; Kim, M. G.; Pamukcu, R.; Li, H.; Piazza, G. A.; Thompson, W. J.; Weinstein, I. B. Clin. Cancer Res. 2000, 6, 4136-4141.
PMid:11051267
[7]. Alagille, D.; Baldwin, R. M.; Tamagnan, G. D. Tetrahedron Lett. 2004, 45, 6179-6181.
http://dx.doi.org/10.1016/j.tetlet.2004.06.007
[8]. Raj, T.; Bhatia, R. K.; Kapur, A.; Sharma, M.; Saxena, A. K.; Ishar, M. P. S. Eur. J. Med. Chem. 2010, 45, 790-794.
http://dx.doi.org/10.1016/j.ejmech.2009.11.001
PMid:19939522
[9]. Endo, S.; Matsunaga, T.; Kuwata, K.; Zhao, H. T.; El-Kabbani, O.; Kitade, Y.; Hara, A. Bioorg. Med. Chem. 2010, 18, 2485-2490.
http://dx.doi.org/10.1016/j.bmc.2010.02.050
[10]. Sabry, N. M.; Mohamed, H. M.; Shawky, E.; Khattab, A. E. H.; Motlaq, S. S.; El-Agrody, A. M. Eur. J. Med. Chem. 2011, 46, 765-772.
http://dx.doi.org/10.1016/j.ejmech.2010.12.015
PMid:21216502
[11]. Ghorab, M. M.; Ragab, F. A.; Hamed, M. M. Eur. J. Med. Chem. 2009, 44, 4211-4217.
http://dx.doi.org/10.1016/j.ejmech.2009.05.017
PMid:19540022
[12]. Al-Said, M. S.; Ghorab, M. M.; Al-Qasoumi, S. I.; El-Hossary, E. M.; Noaman, E. Eur. J. Med. Chem. 2010, 45, 3011-3018.
http://dx.doi.org/10.1016/j.ejmech.2010.03.030
PMid:20413187
[13]. Al-Qasoumi, S. I.; Al-Taweel, A. M.; Alafeey, A. M.; Ghorab, M. M.; Noaman, E. Bioorg. Med. Chem. Lett. 2009, 19, 6939-6942.
http://dx.doi.org/10.1016/j.bmcl.2009.10.065
[14]. Ghorab, M. M.; Ragab, F. A.; Al-Qasoumi, S. I.; Alafeefy, A. M.; Aboulmagd, S. A. Eur. J. Med. Chem. 2010, 45, 171-178.
http://dx.doi.org/10.1016/j.ejmech.2009.09.039
PMid:19853327
[15]. Al-Qasoumi, S. I.; Al-Taweel, A. M.; Al-Afeefy, A. M.; Noaman, E.; Ghorab, M. M. Eur. J. Med. Chem. 2010, 45, 738-744.
http://dx.doi.org/10.1016/j.ejmech.2009.11.021
PMid:19944497
[16]. Al-Qasoumi, S. I.; Al-Taweel, A. M.; Alafeefy, A. M.; Ghorab, M. M.; Noaman, E. Eur. J. Med. Chem. 2010, 45, 1849-1853.
http://dx.doi.org/10.1016/j.ejmech.2010.01.022
PMid:20149941
[17]. Devi, P. U.; Solomon, F. E.; Sharada, A. C. Pharm. Biol. 1999, 37(3), 231-236.
http://dx.doi.org/10.1076/phbi.37.3.231.6299
[18]. Skehan, P.; Storeng, R.; Scudiero, D.; Monks, A.; McMahon, J.; Vistica, D.; Warren, J. T.; Bokesch, H.; Kenney, S.; Boyd, M. R. J. Natl. Cancer Inst. 1990, 82, 1107-1112.
http://dx.doi.org/10.1093/jnci/82.13.1107
[19]. Nishimura, Y. Int. J. Clin. Oncol. 2004, 9, 414-420.
http://dx.doi.org/10.1007/s10147-004-0443-z
PMid:15616871
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