European Journal of Chemistry 2012, 3(2), 228-234. doi:10.5155/eurjchem.3.2.228-234.596

In-vitro cytotoxic and radiosensitizing evaluation of novel 2-pyridone, isoquinoline, chromene and chromenopyridone derivatives


Mansour Sulaiman Al-Said (1) , Marwa Galal El-Gazzar (2) , Mostafa Mohammed Ghorab (3,*)

(1) Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia
(2) Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, 11371, Egypt
(3) Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia
(*) Corresponding Author

Received: 10 Feb 2012, Accepted: 28 Mar 2012, Published: 30 Jun 2012

Abstract


On the account of the reported anticancer activity of 2-pyridone, a new series of ethyl-1,6-dihydropyridine-3-carboxylate (4a-j), 1-oxo-1,2-dihydroisoquinoline-7-carbonitrile (6a-h), 2H-chromene (7,8) and 3H-chromeno[3,4-c]pyridone derivatives (9,10) were synthesized and tested for in-vitro anticancer activity against Ehrlich Ascites Carcinoma (EAC) cell line and human liver cell line (HEPG2). The structures of the synthesized compounds were confirmed by analytical and spectral data. Furthermore, radiosensitization study was performed for the most potent compounds (4a, 4d, 6a, 6c, 6e and 10).

3_2_228_234_800


Keywords


Cytotoxic; Chromene; 2-Pyridone; Isoquinoline; Radiosensitizing; Chromenopyridone

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DOI: 10.5155/eurjchem.3.2.228-234.596

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[2]. S. Trichili, M. Kammoun, S. Abid, H. Ammar
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[3]. Mostafa Ghorab, Marwa El-Gazzar, Mansour Alsaid
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[4]. Shivaputra A Patil, Renukadevi Patil, Lawrence M Pfeffer, Duane D Miller
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[5]. Pintu Kumar Mandal
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How to cite


Al-Said, M.; El-Gazzar, M.; Ghorab, M. Eur. J. Chem. 2012, 3(2), 228-234. doi:10.5155/eurjchem.3.2.228-234.596
Al-Said, M.; El-Gazzar, M.; Ghorab, M. In-vitro cytotoxic and radiosensitizing evaluation of novel 2-pyridone, isoquinoline, chromene and chromenopyridone derivatives. Eur. J. Chem. 2012, 3(2), 228-234. doi:10.5155/eurjchem.3.2.228-234.596
Al-Said, M., El-Gazzar, M., & Ghorab, M. (2012). In-vitro cytotoxic and radiosensitizing evaluation of novel 2-pyridone, isoquinoline, chromene and chromenopyridone derivatives. European Journal of Chemistry, 3(2), 228-234. doi:10.5155/eurjchem.3.2.228-234.596
Al-Said, Mansour, Marwa Galal El-Gazzar, & Mostafa Mohammed Ghorab. "In-vitro cytotoxic and radiosensitizing evaluation of novel 2-pyridone, isoquinoline, chromene and chromenopyridone derivatives." European Journal of Chemistry [Online], 3.2 (2012): 228-234. Web. 21 Sep. 2019
Al-Said, Mansour, El-Gazzar, Marwa, AND Ghorab, Mostafa. "In-vitro cytotoxic and radiosensitizing evaluation of novel 2-pyridone, isoquinoline, chromene and chromenopyridone derivatives" European Journal of Chemistry [Online], Volume 3 Number 2 (30 June 2012)

DOI Link: https://doi.org/10.5155/eurjchem.3.2.228-234.596

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