European Journal of Chemistry

In-vitro cytotoxic and radiosensitizing evaluation of novel 2-pyridone, isoquinoline, chromene and chromenopyridone derivatives



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Mansour Sulaiman Al-Said
Marwa Galal El-Gazzar
Mostafa Mohammed Ghorab

Abstract

On the account of the reported anticancer activity of 2-pyridone, a new series of ethyl-1,6-dihydropyridine-3-carboxylate (4a-j), 1-oxo-1,2-dihydroisoquinoline-7-carbonitrile (6a-h), 2H-chromene (7,8) and 3H-chromeno[3,4-c]pyridone derivatives (9,10) were synthesized and tested for in-vitro anticancer activity against Ehrlich Ascites Carcinoma (EAC) cell line and human liver cell line (HEPG2). The structures of the synthesized compounds were confirmed by analytical and spectral data. Furthermore, radiosensitization study was performed for the most potent compounds (4a, 4d, 6a, 6c, 6e and 10).

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Al-Said, M. S.; El-Gazzar, M. G.; Ghorab, M. M. In-Vitro Cytotoxic and Radiosensitizing Evaluation of Novel 2-Pyridone, Isoquinoline, Chromene and Chromenopyridone Derivatives. Eur. J. Chem. 2012, 3, 228-234.

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The Research Center, College of Pharmacy and the Deanship of Scientific Research, King Saud University, Riyadh, Saudi Arabia
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