European Journal of Chemistry

In-vitro cytotoxic and radiosensitizing evaluation of novel 2-pyridone, isoquinoline, chromene and chromenopyridone derivatives

Article Sidebar

PDF
Published: Jun 30, 2012
DOI: https://doi.org/10.5155/eurjchem.3.2.228-234.596
Keywords:
Cytotoxic, Chromene, 2-Pyridone, Isoquinoline, Radiosensitizing, Chromenopyridone
Section
Research Article
Issue
Vol. 3 No. 2 (2012): June 2012
Dates
Received 2012-02-10
Accepted 2012-03-16
Published 2012-06-30


Main Article Content

Mansour Sulaiman Al-Said
Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia
Marwa Galal El-Gazzar
Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, 11371, Egypt
Mostafa Mohammed Ghorab
Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

Abstract

On the account of the reported anticancer activity of 2-pyridone, a new series of ethyl-1,6-dihydropyridine-3-carboxylate (4a-j), 1-oxo-1,2-dihydroisoquinoline-7-carbonitrile (6a-h), 2H-chromene (7,8) and 3H-chromeno[3,4-c]pyridone derivatives (9,10) were synthesized and tested for in-vitro anticancer activity against Ehrlich Ascites Carcinoma (EAC) cell line and human liver cell line (HEPG2). The structures of the synthesized compounds were confirmed by analytical and spectral data. Furthermore, radiosensitization study was performed for the most potent compounds (4a, 4d, 6a, 6c, 6e and 10).

3_2_228_234_800


icon graph This Abstract was viewed 1614 times | icon graph Article PDF downloaded 675 times

How to Cite
(1)
Al-Said, M. S.; El-Gazzar, M. G.; Ghorab, M. M. In-Vitro Cytotoxic and Radiosensitizing Evaluation of Novel 2-Pyridone, Isoquinoline, Chromene and Chromenopyridone Derivatives. Eur. J. Chem. 2012, 3, 228-234.

Article Details

Share
Links for Article


Crossref - Scopus - Google - European PMC
Crossref
Scopus
Google Scholar
Europe PMC
References

[1]. Abadi, A. H.; Ibrahim, T. M.; Abouzid, K. M.; Lehmann. J.; Tinsley, H. N.; Gary, B. D.; Piazza, G. A. Bioorg. Med. Chem. 2009, 17, 5974-5982.
http://dx.doi.org/10.1016/j.bmc.2009.06.063

[2]. Cheney, I. W.; Yan, S.; Appleby, T.; Walker, H.; Vo, T.; Yao, N.; Hamatake, R.; Hong, Z.; Wu, J. Z. Bioorg. Med. Chem. Lett. 2007, 17, 1679-1683.
http://dx.doi.org/10.1016/j.bmcl.2006.12.086

[3]. Wendt, M. D.; Sun, C.; Kunzer, A.; Sauer, D.; Sarris, K.; Hoff, E.; Yu, L.; Nettesheim, D. G.; Chen, J.; Jin, S.; Comess, K. M.; Fan, Y.; Anderson, S. N.; Isaac, B.; Olejniczak, E. T.; Hajduk, P. J.; Rosenberg, S. H.; Elmore, S. W. Bioorg. Med. Chem. Lett. 2007, 17, 3122-3129.
http://dx.doi.org/10.1016/j.bmcl.2007.03.042

[4]. Aqui, N. A.; Vonderheide, R. H. Cancer Biol. Ther. 2008, 7, 1888-1889.
http://dx.doi.org/10.4161/cbt.7.12.7219

[5]. Ambrosini, G.; Adida, C.; Altieri, D. C. Nat. Med. 1997, 3, 917-921.
http://dx.doi.org/10.1038/nm0897-917
PMid:9256286

[6]. Gary, P.; Soh, J. W.; Mao, Y.; Kim, M. G.; Pamukcu, R.; Li, H.; Piazza, G. A.; Thompson, W. J.; Weinstein, I. B. Clin. Cancer Res. 2000, 6, 4136-4141.
PMid:11051267

[7]. Alagille, D.; Baldwin, R. M.; Tamagnan, G. D. Tetrahedron Lett. 2004, 45, 6179-6181.
http://dx.doi.org/10.1016/j.tetlet.2004.06.007

[8]. Raj, T.; Bhatia, R. K.; Kapur, A.; Sharma, M.; Saxena, A. K.; Ishar, M. P. S. Eur. J. Med. Chem. 2010, 45, 790-794.
http://dx.doi.org/10.1016/j.ejmech.2009.11.001
PMid:19939522

[9]. Endo, S.; Matsunaga, T.; Kuwata, K.; Zhao, H. T.; El-Kabbani, O.; Kitade, Y.; Hara, A. Bioorg. Med. Chem. 2010, 18, 2485-2490.
http://dx.doi.org/10.1016/j.bmc.2010.02.050

[10]. Sabry, N. M.; Mohamed, H. M.; Shawky, E.; Khattab, A. E. H.; Motlaq, S. S.; El-Agrody, A. M. Eur. J. Med. Chem. 2011, 46, 765-772.
http://dx.doi.org/10.1016/j.ejmech.2010.12.015
PMid:21216502

[11]. Ghorab, M. M.; Ragab, F. A.; Hamed, M. M. Eur. J. Med. Chem. 2009, 44, 4211-4217.
http://dx.doi.org/10.1016/j.ejmech.2009.05.017
PMid:19540022

[12]. Al-Said, M. S.; Ghorab, M. M.; Al-Qasoumi, S. I.; El-Hossary, E. M.; Noaman, E. Eur. J. Med. Chem. 2010, 45, 3011-3018.
http://dx.doi.org/10.1016/j.ejmech.2010.03.030
PMid:20413187

[13]. Al-Qasoumi, S. I.; Al-Taweel, A. M.; Alafeey, A. M.; Ghorab, M. M.; Noaman, E. Bioorg. Med. Chem. Lett. 2009, 19, 6939-6942.
http://dx.doi.org/10.1016/j.bmcl.2009.10.065

[14]. Ghorab, M. M.; Ragab, F. A.; Al-Qasoumi, S. I.; Alafeefy, A. M.; Aboulmagd, S. A. Eur. J. Med. Chem. 2010, 45, 171-178.
http://dx.doi.org/10.1016/j.ejmech.2009.09.039
PMid:19853327

[15]. Al-Qasoumi, S. I.; Al-Taweel, A. M.; Al-Afeefy, A. M.; Noaman, E.; Ghorab, M. M. Eur. J. Med. Chem. 2010, 45, 738-744.
http://dx.doi.org/10.1016/j.ejmech.2009.11.021
PMid:19944497

[16]. Al-Qasoumi, S. I.; Al-Taweel, A. M.; Alafeefy, A. M.; Ghorab, M. M.; Noaman, E. Eur. J. Med. Chem. 2010, 45, 1849-1853.
http://dx.doi.org/10.1016/j.ejmech.2010.01.022
PMid:20149941

[17]. Devi, P. U.; Solomon, F. E.; Sharada, A. C. Pharm. Biol. 1999, 37(3), 231-236.
http://dx.doi.org/10.1076/phbi.37.3.231.6299

[18]. Skehan, P.; Storeng, R.; Scudiero, D.; Monks, A.; McMahon, J.; Vistica, D.; Warren, J. T.; Bokesch, H.; Kenney, S.; Boyd, M. R. J. Natl. Cancer Inst. 1990, 82, 1107-1112.
http://dx.doi.org/10.1093/jnci/82.13.1107

[19]. Nishimura, Y. Int. J. Clin. Oncol. 2004, 9, 414-420.
http://dx.doi.org/10.1007/s10147-004-0443-z
PMid:15616871

Most read articles by the same author(s)
TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).