European Journal of Chemistry

In-vitro cytotoxic and radiosensitizing evaluation of novel 2-pyridone, isoquinoline, chromene and chromenopyridone derivatives

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Published: Jun 30, 2012
DOI: https://doi.org/10.5155/eurjchem.3.2.228-234.596
Keywords:
Cytotoxic, Chromene, 2-Pyridone, Isoquinoline, Radiosensitizing, Chromenopyridone
Section
Research Article
Issue
Vol. 3 No. 2 (2012): June 2012
Dates
Received 2012-02-10
Accepted 2012-03-28
Published 2012-06-30


Main Article Content

Mansour Sulaiman Al-Said
Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia
Marwa Galal El-Gazzar
Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, 11371, Egypt
Mostafa Mohammed Ghorab
Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

Abstract

On the account of the reported anticancer activity of 2-pyridone, a new series of ethyl-1,6-dihydropyridine-3-carboxylate (4a-j), 1-oxo-1,2-dihydroisoquinoline-7-carbonitrile (6a-h), 2H-chromene (7,8) and 3H-chromeno[3,4-c]pyridone derivatives (9,10) were synthesized and tested for in-vitro anticancer activity against Ehrlich Ascites Carcinoma (EAC) cell line and human liver cell line (HEPG2). The structures of the synthesized compounds were confirmed by analytical and spectral data. Furthermore, radiosensitization study was performed for the most potent compounds (4a, 4d, 6a, 6c, 6e and 10).

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Al-Said, M. S.; El-Gazzar, M. G.; Ghorab, M. M. In-Vitro Cytotoxic and Radiosensitizing Evaluation of Novel 2-Pyridone, Isoquinoline, Chromene and Chromenopyridone Derivatives. Eur. J. Chem. 2012, 3, 228-234.

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The Research Center, College of Pharmacy and the Deanship of Scientific Research, King Saud University, Riyadh, Saudi Arabia
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