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In-vitro cytotoxic and radiosensitizing evaluation of novel 2-pyridone, isoquinoline, chromene and chromenopyridone derivatives
Mansour Sulaiman Al-Said (1)
, Marwa Galal El-Gazzar (2) , Mostafa Mohammed Ghorab (3,*) (1) Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia
(2) Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, 11371, Egypt
(3) Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia
(*) Corresponding Author
Received: 10 Feb 2012 | Revised: 16 Mar 2012 | Accepted: 28 Mar 2012 | Published: 30 Jun 2012 | Issue Date: June 2012
Abstract
On the account of the reported anticancer activity of 2-pyridone, a new series of ethyl-1,6-dihydropyridine-3-carboxylate (4a-j), 1-oxo-1,2-dihydroisoquinoline-7-carbonitrile (6a-h), 2H-chromene (7,8) and 3H-chromeno[3,4-c]pyridone derivatives (9,10) were synthesized and tested for in-vitro anticancer activity against Ehrlich Ascites Carcinoma (EAC) cell line and human liver cell line (HEPG2). The structures of the synthesized compounds were confirmed by analytical and spectral data. Furthermore, radiosensitization study was performed for the most potent compounds (4a, 4d, 6a, 6c, 6e and 10).
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.3.2.228-234.596
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The Research Center, College of Pharmacy and the Deanship of Scientific Research, King Saud University, Riyadh, Saudi Arabia
Citations
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[2]. Zainab Almarhoon, Hessa H. Al Rasheed, Ayman El-Faham
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[4]. S. Trichili, M. Kammoun, S. Abid, H. Ammar
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DOI Link: https://doi.org/10.5155/eurjchem.3.2.228-234.596
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