European Journal of Chemistry 2013, 4(2), 132-137. doi:10.5155/eurjchem.4.2.132-137.746

Solvent-free synthesis of 2H-indazolo[2,1-b] phthalazine-triones promoted by cavitational phenomenon using iodine as catalyst


Anitha Varghese (1,*) , Aatika Nizam (2) , Rajani Kulkarni (3) , Louis George (4)

(1) Department of Chemistry, Christ University, Bangalore, 560 029, India
(2) Department of Chemistry, Christ University, Bangalore, 560 029, India
(3) Department of Chemistry, Christ University, Bangalore, 560 029, India
(4) Department of Chemistry, Christ University, Bangalore, 560 029, India
(*) Corresponding Author

Received: 11 Feb 2013, Accepted: 13 Mar 2013, Published: 30 Jun 2013

Abstract


An environmentally benign, simple and efficient protocol for the synthesis of 2H-indazolo[2,1-b] phthalazine-triones by condensation of phthalhydrazide, aromatic aldehydes and dimedone under solvent-free ultrasound assisted conditions employing a safe, readily available iodine as catalyst has been described. This process is a valuable addition as it devoids the use of any solvent and takes place in short duration of time giving good yield of the products.

4_2_132_137

Keywords


Iodine; Dimedone; Phthalhydrazide; Aromatic aldehydes; Cavitational chemistry; 2H-Indazolo[2,1-b]phthalazine-triones

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DOI: 10.5155/eurjchem.4.2.132-137.746

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Citations

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[1]. Cinnathambi Subramani Maheswari, Chandrabose Shanmugapriya, Krishnan Revathy, Appaswami Lalitha
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[3]. Maryam Mousapour, Farhad Shirini, Masoumeh Abedini
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[4]. Masoumeh Abedini, Farhad Shirini, Javad Mohammad-Alinejad Omran
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[5]. Omid Goli-Jolodar, Farhad Shirini, Mohadeseh Seddighi
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[6]. O. Goli-Jolodar, F. Shirini
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[7]. Farhad Shirini, Mohaddeseh Safarpoor Nikoo Langarudi, Omid Goli-Jolodar
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[8]. Lilin Jiang, Zumrat Druzhinin
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How to cite


Varghese, A.; Nizam, A.; Kulkarni, R.; George, L. Eur. J. Chem. 2013, 4(2), 132-137. doi:10.5155/eurjchem.4.2.132-137.746
Varghese, A.; Nizam, A.; Kulkarni, R.; George, L. Solvent-free synthesis of 2H-indazolo[2,1-b] phthalazine-triones promoted by cavitational phenomenon using iodine as catalyst. Eur. J. Chem. 2013, 4(2), 132-137. doi:10.5155/eurjchem.4.2.132-137.746
Varghese, A., Nizam, A., Kulkarni, R., & George, L. (2013). Solvent-free synthesis of 2H-indazolo[2,1-b] phthalazine-triones promoted by cavitational phenomenon using iodine as catalyst. European Journal of Chemistry, 4(2), 132-137. doi:10.5155/eurjchem.4.2.132-137.746
Varghese, Anitha, Aatika Nizam, Rajani Kulkarni, & Louis George. "Solvent-free synthesis of 2H-indazolo[2,1-b] phthalazine-triones promoted by cavitational phenomenon using iodine as catalyst." European Journal of Chemistry [Online], 4.2 (2013): 132-137. Web. 16 Sep. 2019
Varghese, Anitha, Nizam, Aatika, Kulkarni, Rajani, AND George, Louis. "Solvent-free synthesis of 2H-indazolo[2,1-b] phthalazine-triones promoted by cavitational phenomenon using iodine as catalyst" European Journal of Chemistry [Online], Volume 4 Number 2 (30 June 2013)

DOI Link: https://doi.org/10.5155/eurjchem.4.2.132-137.746

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