Solvent-free synthesis of 2H-indazolo[2,1-b] phthalazine-triones promoted by cavitational phenomenon using iodine as catalyst

Anitha Varghese; Aatika Nizam; Rajani Kulkarni; Louis George

doi:10.5155/eurjchem.4.2.132-137.746

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Published: Jun 30, 2013

DOI: https://doi.org/10.5155/eurjchem.4.2.132-137.746

Keywords:

Iodine, Dimedone, Phthalhydrazide, Aromatic aldehydes, Cavitational chemistry, 2H-Indazolo[2, 1-b]phthalazine-triones

Section

Research Article

Issue

Vol. 4 No. 2 (2013): June 2013

Dates

Received 2013-02-11
Accepted 2013-02-18
Published 2013-06-30

Anitha Varghese

Department of Chemistry, Christ University, Bangalore, 560 029, India

Aatika Nizam

Department of Chemistry, Christ University, Bangalore, 560 029, India

Rajani Kulkarni

Department of Chemistry, Christ University, Bangalore, 560 029, India

Louis George

Department of Chemistry, Christ University, Bangalore, 560 029, India

Abstract

An environmentally benign, simple and efficient protocol for the synthesis of 2H-indazolo[2,1-b] phthalazine-triones by condensation of phthalhydrazide, aromatic aldehydes and dimedone under solvent-free ultrasound assisted conditions employing a safe, readily available iodine as catalyst has been described. This process is a valuable addition as it devoids the use of any solvent and takes place in short duration of time giving good yield of the products.

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Varghese, A.; Nizam, A.; Kulkarni, R.; George, L. Solvent-Free Synthesis of 2H-indazolo[2,1-B] Phthalazine-Triones Promoted by Cavitational Phenomenon Using Iodine As Catalyst. Eur. J. Chem. 2013, 4, 132-137.

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