European Journal of Chemistry

An efficient synthesis of some new isolated and fused 2-oxo-2H-chromene derivatives as antimicrobial and antitumor agents

Main Article Content

Hafez Mohamed El-Shaaer


An efficient synthesis of the biologically active novel systems derived from the reaction of 4-methyl-2-oxo-2H-chromene-3-carbonitrile (1) with sodium hydroxide and/or DMF-DMA and cyclocondensation reactions of 4-[(E)-2-(dimethylamino)ethenyl]-2-oxo-2H-chromene-3-carbonitrile (5) with nitrogen nucleophilic reagents afforded the corresponding 4-iminochromeno[3,4-c]pyridine derivatives (6-14). The structures of the prepared compounds have been proved by elemental analysis, IR, 1H  and 13C NMR and mass spectra. Significant antitumor activities in planta were observed for some of the prepared compounds.


icon graph This Abstract was viewed 1877 times | icon graph Article PDF downloaded 810 times

How to Cite
El-Shaaer, H. M. An Efficient Synthesis of Some New Isolated and Fused 2-Oxo-2H-Chromene Derivatives As Antimicrobial and Antitumor Agents. Eur. J. Chem. 2013, 4, 138-145.

Article Details

Crossref - Scopus - Google - European PMC

[1]. El-Sayed, A. M.; Abdallah, O. A. Phosphorus, Sulfur, and Silicon 2001, 170, 75-86.

[2]. El-Shaaer, H. M. Eur. J. Chem. 2012, 3(1), 51-56.

[3]. Ali, T. E.; Abdel-Aziz, S. A.; El-Shaaer, H. M.; Hanafy, F. I.; El-Fauomy, A. Z. Phosphorus, Sulfur, and Silicon 2008, 183, 2139-2160.

[4]. Ali, T. E.; Abdel-Aziz, S. A.; El-Shaaer, H. M.; Hanafy, F. I.; El-Fauomy, A. Z. Turk. J. Chem. 2008, 32, 365-374.

[5]. El-Shaaer, H. M.; Foltinova, P.; Lacova, M.; Chovancova, J.; Stankovicova, H. Il Farmaco 1998, 53, 224-232.

[6]. Gasparova, R.; Lacova, M.; El-Shaaer, H. M.; Odlerova, Z. Il Farmaco 1997, 52, 251-253.

[7]. Manolov, I.; Maichle-Moessmer, C.; Danchev, N. Eur. J. Med. Chem. 2006, 41, 882-890.

[8]. Manolov, I.; Maichle-Moessmer, C.; Nicolova, I.; Danchev, N. Arch. Pharm. 2006, 336, 319-326.

[9]. Jackson, S. A.; Sahni, S.; Lee, L.; Luo, Y.; Nieduzak, T. R. Bioorg. Med. Chem. 2005, 13, 2723-2739.

[10]. Choudhary, M.; Fatima, N.; Khan, K.; Jalil, S.; Iqbal, S.; Rahman, A. Bioorg. Med. Chem. 2006, 14, 8066-8072.

[11]. Cravotto, G.; Tagliapietra, S.; Cappelo, R.; Palmisano, G.; Curini, M.; Boccalini, M. Arch. Pharm. 2006, 336, 129-132.

[12]. Ishar, M. P. S.; Singh, G.; Singh, S.; Sreenivasan, K. K.; Singh, G. Bioorg. Med. Chem. Lett. 2006, 16, 1366-1370.

[13]. Liu, J.; Wu, J.; Zhao, Y. X.; Deng, Y. Y.; Mei, W. L.; Dai, H. F. Chin. Chem. Lett. 2008, 19, 934-936.

[14]. Lacova, M.; Gasparova, R.; Kois, P.; Bohac, A.; El-Shaaer, H. M. Tetrahedron 2010, 66, 1410-1419.

[15]. Gaplovsky, A.; Donovalova, J.; Lacova, M.; Mracnova, R.; El-Shaaer, H. M. J. Photochem. Photobiol. A 2000, 136, 61-65.

[16]. El-Shaaer, H. M.; Abdel-Aziz, S. A.; Hanafy, F. I.; Ali, T. E.; El-Fauomy, A. Z. Eur. J. Chem. 2011, 2(2), 158-162.

[17]. El-Shaaer, H. M.; Perjessy, A.; Zahradnik, P.; Lacova, M.; Sustekova, Z. Monatsh. Chem. 1993, 124, 539-548.

[18]. El-Shaaer, H. M.; Ibrahim, S. S.; Abd-Elmonem, W. R.; Ibrahim, C. G. Eur. J. Chem. 2012, 3(2), 172-178.

[19]. Dornow, A.; Menzel, M. P. Chem. Ber. 1964, 97, 2173-2178.

[20]. Bauer, A. W.; Kirby, W. W. M.; Sherris, J. C.; Turck, M. Am. J. Clin. Path. 1966, 45, 493-496.

Supporting Agencies

Ain Shams University, Roxy, 11711, Cairo, Egypt

Dimensions - Altmetric - scite_ - PlumX

Downloads and views


Download data is not yet available.


Metrics Loading ...
License Terms

License Terms


Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License ( By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License ( are administered by Atlanta Publishing House LLC (European Journal of Chemistry).