

An efficient synthesis of some new isolated and fused 2-oxo-2H-chromene derivatives as antimicrobial and antitumor agents
Hafez Mohamed El-Shaaer (1,*)

(1) Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt
(*) Corresponding Author
Received: 14 Feb 2013 | Revised: 28 Mar 2013 | Accepted: 30 Mar 2013 | Published: 30 Jun 2013 | Issue Date: June 2013
Abstract
An efficient synthesis of the biologically active novel systems derived from the reaction of 4-methyl-2-oxo-2H-chromene-3-carbonitrile (1) with sodium hydroxide and/or DMF-DMA and cyclocondensation reactions of 4-[(E)-2-(dimethylamino)ethenyl]-2-oxo-2H-chromene-3-carbonitrile (5) with nitrogen nucleophilic reagents afforded the corresponding 4-iminochromeno[3,4-c]pyridine derivatives (6-14). The structures of the prepared compounds have been proved by elemental analysis, IR, 1H and 13C NMR and mass spectra. Significant antitumor activities in planta were observed for some of the prepared compounds.

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European Journal of Chemistry
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DOI: 10.5155/eurjchem.4.2.138-145.749
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Ain Shams University, Roxy, 11711, Cairo, Egypt
Citations
[1]. Zahira Kibou, Didier Villemin, Jean-François Lohier, Nawel Cheikh, Nathalie Bar, Noureddine Choukchou-Braham
Easy solventless synthesis of new mono and bis amino-5H-chromeno [3,4-c] pyridin-5-one derivatives
Tetrahedron 72(13), 1653, 2016
DOI: 10.1016/j.tet.2016.01.063

[2]. Jian Xiao, Yuye Chen, Shuai Zhu, Liang Wang, Lubin Xu, Hongtao Wei
Diversified Construction of Chromeno[3,4-c]pyridin-5-one and Benzo[c]chromen-6-one Derivatives by Domino Reaction of 4-Alkynyl-2-oxo-2H-chromene-3-carbaldehydes
Advanced Synthesis & Catalysis 356(8), 1835, 2014
DOI: 10.1002/adsc.201301171

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