European Journal of Chemistry 2011, 2(2), 158-162. doi:10.5155/eurjchem.2.2.158-162.381

Synthesis, antifungal activity and semi-empirical AM1-MO calculations of some new 4-oxo-4H-chromene derivatives


Hafez Mohamed El-Shaaer (1) , Salah Abdel-Ghaffar Abdel-Aziz (2) , Faten Ismail Hanafy (3) , Tarik El-Sayed Ali (4,*) , Ali Zaky El-Fauomy (5)

(1) Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt
(2) Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt
(3) Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt
(4) Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt
(5) Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt
(*) Corresponding Author

Received: 01 Jan 2011, Accepted: 09 Feb 2011, Published: 30 Jun 2011

Abstract


Some new antifungal agents have been prepared through reaction of 4-oxo-4H-chromene-3-carbaldehydes (1a,b) with some active primary amines (2a-e) and amides/thioamides (6a-d) in different conditions. Structures of the products were established on the basis of elemental analysis, IR, 1H NMR, mass spectra and semi-empirical AM1-MO calculations.2_2_158_162_800

Keywords


Synthesis; Chromone; Chromone Derivatives; 3-Formylchromones; Antifungal activity; AM1-MO Calculation

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DOI: 10.5155/eurjchem.2.2.158-162.381

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[1]. Hafez Mohamed El-Shaaer, Salah Sayed Ibrahim, Wafaa Ramzy Abd-Elmonem, Christine Gamal Ibrahim
An efficient cyclocondensation reactions, antimicrobial activity and molecular orbital calculations of α-benzopyrone derivatives
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DOI: 10.5155/eurjchem.3.2.172-178.582
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[2]. Hafez Mohamed El-Shaaer
An efficient synthesis of some new isolated and fused 2-oxo-2H-chromene derivatives as antimicrobial and antitumor agents
European Journal of Chemistry  4(2), 138, 2013
DOI: 10.5155/eurjchem.4.2.138-145.749
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[3]. H. Surya Prakash Rao, Venkata Swamy Tangeti, Lakshmi Narayana Adigopula
Synthesis and antimicrobial evaluation of 2-hydroxynaphthalene-1,4-dione and 4H-chromene conjugates
Research on Chemical Intermediates  42(10), 7285, 2016
DOI: 10.1007/s11164-016-2536-5
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[4]. Nayim Sepay, Sankar P. Dey
Synthesis and Chemical Reactivity of 4-Oxo-4H-1-benzopyran-3-carboxaldehyde
Journal of Heterocyclic Chemistry  51(S1), E1, 2014
DOI: 10.1002/jhet.2001
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[5]. Fadi M. Awadallah, Tamer A. El-Waei, Mona M. Hanna, Safinaz E. Abbas, Mariangela Ceruso, Beyza Ecem Oz, Ozen Ozensoy Guler, Claudiu T. Supuran
Synthesis, carbonic anhydrase inhibition and cytotoxic activity of novel chromone-based sulfonamide derivatives
European Journal of Medicinal Chemistry  96, 425, 2015
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[6]. Hafez Mohamed El-Shaaer, Wafaa Ramzy Abd-Elmonem, Salah Sayed Ibrahim, Christine Gamal Ibrahim
Study of the Reactivity of 6,8-Dimethyl-4-oxo-4H-1-benzopyran-3-carboxaldehyde Towards Amino-6-oxopyridine-3-carboxylate Derivatives
Journal of Heterocyclic Chemistry  51(S1), E167, 2014
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[7]. Ahmed Bari, Mohammad Khalid Parvez, Azmat Ali Khan, Amer M. Alanazi, Saeed Ali Syed, Mohammed S. Al-Dosari, Abdulrahman M. Alobaid
A Facile One-Pot Synthesis and Anticancer Evaluation of Novel Substituted 1,2-Dihydropyridine and 1,2,3,4-Tetrahydropyrimidine Analogues
Journal of Heterocyclic Chemistry  53(2), 377, 2016
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How to cite


El-Shaaer, H.; Abdel-Aziz, S.; Hanafy, F.; Ali, T.; El-Fauomy, A. Eur. J. Chem. 2011, 2(2), 158-162. doi:10.5155/eurjchem.2.2.158-162.381
El-Shaaer, H.; Abdel-Aziz, S.; Hanafy, F.; Ali, T.; El-Fauomy, A. Synthesis, antifungal activity and semi-empirical AM1-MO calculations of some new 4-oxo-4H-chromene derivatives. Eur. J. Chem. 2011, 2(2), 158-162. doi:10.5155/eurjchem.2.2.158-162.381
El-Shaaer, H., Abdel-Aziz, S., Hanafy, F., Ali, T., & El-Fauomy, A. (2011). Synthesis, antifungal activity and semi-empirical AM1-MO calculations of some new 4-oxo-4H-chromene derivatives. European Journal of Chemistry, 2(2), 158-162. doi:10.5155/eurjchem.2.2.158-162.381
El-Shaaer, Hafez, Salah Abdel-Ghaffar Abdel-Aziz, Faten Ismail Hanafy, Tarik El-Sayed Ali, & Ali Zaky El-Fauomy. "Synthesis, antifungal activity and semi-empirical AM1-MO calculations of some new 4-oxo-4H-chromene derivatives." European Journal of Chemistry [Online], 2.2 (2011): 158-162. Web. 21 Oct. 2019
El-Shaaer, Hafez, Abdel-Aziz, Salah, Hanafy, Faten, Ali, Tarik, AND El-Fauomy, Ali. "Synthesis, antifungal activity and semi-empirical AM1-MO calculations of some new 4-oxo-4H-chromene derivatives" European Journal of Chemistry [Online], Volume 2 Number 2 (30 June 2011)

DOI Link: https://doi.org/10.5155/eurjchem.2.2.158-162.381

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