Synthesis, antifungal activity and semi-empirical AM1-MO calculations of some new 4-oxo-4H-chromene derivatives | European Journal of Chemistry

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Published: Jun 30, 2011

DOI: https://doi.org/10.5155/eurjchem.2.2.158-162.381

Keywords:

Synthesis, Chromone, Chromone Derivatives, 3-Formylchromones, Antifungal activity, AM1-MO Calculation

Section

Research Article

Issue

Vol. 2 No. 2 (2011): June 2011

Dates

Received 2011-01-01
Accepted 2011-02-09
Published 2011-06-30

Hafez Mohamed El-Shaaer

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Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt

Salah Abdel-Ghaffar Abdel-Aziz

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Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt

Faten Ismail Hanafy

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Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt

Tarik El-Sayed Ali

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Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt

Ali Zaky El-Fauomy

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Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt

Abstract

Some new antifungal agents have been prepared through reaction of 4-oxo-4H-chromene-3-carbaldehydes (1a,b) with some active primary amines (2a-e) and amides/thioamides (6a-d) in different conditions. Structures of the products were established on the basis of elemental analysis, IR, ¹H NMR, mass spectra and semi-empirical AM1-MO calculations. 2_2_158_162_800

2_2_158_162_800

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El-Shaaer, H. M.; Abdel-Aziz, S. A.-G.; Hanafy, F. I.; Ali, T. E.-S.; El-Fauomy, A. Z. Synthesis, Antifungal Activity and Semi-Empirical AM1-MO Calculations of Some New 4-Oxo-4H-Chromene Derivatives. Eur. J. Chem. 2011, 2, 158-162.

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