Synthesis and antimicrobial activity of some new 1,3-thiazoles, 1,3,4-thiadiazoles, 1,2,4-triazoles and 1,3-thiazines incorporating acridine and 1,2,3,4-tetrahydroacridine moieties

Tarik El-Sayed Ali; Azza Mohammed El-Kazak

doi:10.5155/eurjchem.1.1.6-11.12

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Published: Mar 31, 2010

DOI: https://doi.org/10.5155/eurjchem.1.1.6-11.12

Keywords:

Acridine, 1, 2, 3, 4-Tetrahydroacridine, S, N-heterocycles, Antimicrobial Activity

Section

Research Article

Issue

Vol. 1 No. 1 (2010): March 2010

Dates

Received 2010-03-24
Accepted 2010-03-24
Published 2010-03-31

Tarik El-Sayed Ali

Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt

Azza Mohammed El-Kazak

Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt

Abstract

Some new sulfur-nitrogen heterocyclic systems such as 1,3-thiazoles, 1,3,4-thiadiazoles, 1,2,4-triazoles and 1,3-thiazines incorporating acridine and 1,2,3,4-tetrahydroacridine moieties were synthesized via heterocyclization of the key intermediate 4-(acridin-9-yl)-1-(1,2,3,4-tetrahydroacridin-9-ylcarbonyl)thiosemicarbazide. Structures of the new comp-ounds were established by elemental analyses and spectral data. All the products were also screened in vitro for their antimicrobial activity.

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Ali, T. E.-S.; El-Kazak, A. M. Synthesis and Antimicrobial Activity of Some New 1,3-Thiazoles, 1,3,4-Thiadiazoles, 1,2,4-Triazoles and 1,3-Thiazines Incorporating Acridine and 1,2,3,4-Tetrahydroacridine Moieties. Eur. J. Chem. 2010, 1, 6-11.

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