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3-Formylchromones as diverse building blocks in heterocycles synthesis
Tarik El-Sayed Ali (1,*)
, Magdy Ahmed Ibrahim (2) , Nasser Mohamed El-Gohary (3) , Azza Mohamed El‐Kazak (4) (1) Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt
(2) Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt
(3) Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt
(4) Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt
(*) Corresponding Author
Received: 29 Apr 2013 | Accepted: 03 Jun 2013 | Published: 30 Sep 2013 | Issue Date: September 2013
Abstract
This review covers the chemical reactivity of 3-formylchromones towards condensation reactions with a variety of carbon and nitrogen nucleophiles. Some chromone derivatives linked a variety of heterocyclic systems were prepared from the direct condensation of 3-formylchromones with heterocyclic compounds containing active methylene groups. A diverse number of fused heterocyclic systems were prepared from the reaction of 3-formylchromones with some bifunctional nucleophiles, these reactions mainly proceed via condensation with the aldehydic function followed by nucleophilic attack at C-2 position of the chromone moiety.
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DOI: 10.5155/eurjchem.4.3.311-328.815
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