

Synthesis and antimicrobial activities of some novel bis-pyrazole derivatives containing a hydrophosphoryl unit
Salah Abdel-Ghaffar Abdel-Aziz (1)




(1) Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, EG-11711, Egypt
(2) Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, EG-11711, Egypt
(3) Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, EG-11711, Egypt
(4) Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, EG-11711, Egypt
(*) Corresponding Author
Received: 15 Jul 2010 | Revised: 10 Aug 2010 | Accepted: 16 Aug 2010 | Published: 28 Mar 2011 | Issue Date: March 2011
Abstract
Vilsmeier-Haack reaction conditions were applied on some methyl ketone aryl phosphonicdihydrazones to yield some interesting bis-pyrazole derivatives containing a hydro-phosphoryl unit. Bis-{4-formyl-3-aryl-1H-pyrazol-1-yl}phosphine oxides (4a,b) were condensed with some nucleophiles such as aniline, phenacyltriphenylphosphonium bromide and 4-phenylthiosemicarbazide followed by treatment with thioglycolic acid, diethyl phosphite and/or acetic anhydride to yield a novel class of bis-pyrazoles containing sulfur and phosphorus derivatives. Most of the newly synthesized compounds were evaluated for their in vitro antimicrobial activities.
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DOI: 10.5155/eurjchem.2.1.25-35.208
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