European Journal of Chemistry 2011, 2(1), 25-35. doi:10.5155/eurjchem.2.1.25-35.208

Synthesis and antimicrobial activities of some novel bis-pyrazole derivatives containing a hydrophosphoryl unit


Salah Abdel-Ghaffar Abdel-Aziz (1) , Tarik El-Sayed Ali (2,*) , Kamilia Mohamed El-Mahdy (3) , Somaia Mohamed Abdel-Karim (4)

(1) Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, EG-11711, Egypt
(2) Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, EG-11711, Egypt
(3) Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, EG-11711, Egypt
(4) Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, EG-11711, Egypt
(*) Corresponding Author

Received: 15 Jul 2010, Accepted: 16 Aug 2010, Published: 28 Mar 2011

Abstract


Vilsmeier-Haack reaction conditions were applied on some methyl ketone aryl phosphonicdihydrazones to yield some interesting bis-pyrazole derivatives containing a hydro-phosphoryl unit. Bis-{4-formyl-3-aryl-1H-pyrazol-1-yl}phosphine oxides (4a,b) were condensed with some nucleophiles such as aniline, phenacyltriphenylphosphonium bromide and 4-phenylthiosemicarbazide followed by treatment with thioglycolic acid, diethyl phosphite and/or acetic anhydride to yield a novel class of bis-pyrazoles containing sulfur and phosphorus derivatives. Most of the newly synthesized compounds were evaluated for their in vitro antimicrobial activities.

2_1_25_35_800


Keywords


Phosphonicdihydrazones; Hydro-phosphoryl; Vilsmeier-Haack reaction; Bis-pyrazoles; Sulfur-phosphorus heterocycles; Antimicrobial activity

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DOI: 10.5155/eurjchem.2.1.25-35.208

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How to cite


Abdel-Aziz, S.; Ali, T.; El-Mahdy, K.; Abdel-Karim, S. Eur. J. Chem. 2011, 2(1), 25-35. doi:10.5155/eurjchem.2.1.25-35.208
Abdel-Aziz, S.; Ali, T.; El-Mahdy, K.; Abdel-Karim, S. Synthesis and antimicrobial activities of some novel bis-pyrazole derivatives containing a hydrophosphoryl unit. Eur. J. Chem. 2011, 2(1), 25-35. doi:10.5155/eurjchem.2.1.25-35.208
Abdel-Aziz, S., Ali, T., El-Mahdy, K., & Abdel-Karim, S. (2011). Synthesis and antimicrobial activities of some novel bis-pyrazole derivatives containing a hydrophosphoryl unit. European Journal of Chemistry, 2(1), 25-35. doi:10.5155/eurjchem.2.1.25-35.208
Abdel-Aziz, Salah, Tarik El-Sayed Ali, Kamilia Mohamed El-Mahdy, & Somaia Mohamed Abdel-Karim. "Synthesis and antimicrobial activities of some novel bis-pyrazole derivatives containing a hydrophosphoryl unit." European Journal of Chemistry [Online], 2.1 (2011): 25-35. Web. 23 Oct. 2019
Abdel-Aziz, Salah, Ali, Tarik, El-Mahdy, Kamilia, AND Abdel-Karim, Somaia. "Synthesis and antimicrobial activities of some novel bis-pyrazole derivatives containing a hydrophosphoryl unit" European Journal of Chemistry [Online], Volume 2 Number 1 (28 March 2011)

DOI Link: https://doi.org/10.5155/eurjchem.2.1.25-35.208

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