European Journal of Chemistry

Novel heterocyclic derivatives of pyrano[3,2-c]quinolinone from 3-(1-ethy1-4-hydroxy-2-oxo-2(1H)-quinolin-3-yl)-3-oxopropanoic acid

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Published: Sep 29, 2010
DOI: https://doi.org/10.5155/eurjchem.1.3.195-199.91
Keywords:
β-ketoacid, Quinolinone, Chromone, Cyclocondensation, Knoevenagel condensation
Section
Research Article
Issue
Vol. 1 No. 3 (2010): September 2010
Dates
Received 2010-05-05
Accepted 2010-06-08
Published 2010-09-29


Main Article Content

Magdy Ahmed Ibrahim
Department of Chemistry, Faculty of Education, Ain Shams University, Roxy 11711, Cairo, Egypt
Hany Mohamed Hassanin
Department of Chemistry, Faculty of Education, Ain Shams University, Roxy 11711, Cairo, Egypt
Yassin Abdel-Allah Gabr
Department of Chemistry, Faculty of Education, Ain Shams University, Roxy 11711, Cairo, Egypt
Youssef Abdel-Salam Alnamer
Department of Chemistry, Faculty of Education, Ain Shams University, Roxy 11711, Cairo, Egypt

Abstract

3-(1-Ethyl-4-hydroxy-2-oxo-2(1H)-quinolin-3-yl)-3-oxopropanoic acid (2) has been synthesized. The chemical behaviour of β-ketoacid 2 was studied towards condensation reactions with salicylaldelyde, 2-hydroxy-1-naphthaldehyde, 1-phenyl-4-hydroxy-2-oxo-quinoline-3-carboxaldehyde, 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxalde-hyde, 2-amino-3-formylchromone and its 8-allyl analog, 3-cyanochromone and its 8-allyl analog. Structures of the newly synthesized products have been deduced from their elemental analysis and spectral data.

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(1)
Ibrahim, M. A.; Hassanin, H. M.; Gabr, Y. A.-A.; Alnamer, Y. A.-S. Novel Heterocyclic Derivatives of pyrano[3,2-c]quinolinone from 3-(1-Ethy1-4-Hydroxy-2-Oxo-2(1H)-Quinolin-3-Yl)-3-Oxopropanoic Acid. Eur. J. Chem. 2010, 1, 195-199.

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