Synthesis, characterization and comparative study the antibacterial activities of some imine-amoxicillin derivatives

(1) Department of Chemistry, College of Sciences, Al-Mustansiriya University, 10052, Baghdad, Iraq
(2) Department of Chemistry, College of Sciences, Al-Mustansiriya University, 10052, Baghdad, Iraq
(3) Department of Chemistry, College of Sciences, Al-Mustansiriya University, 10052, Baghdad, Iraq
(4) Department of Chemistry, College of Sciences, Al-Mustansiriya University, 10052, Baghdad, Iraq
(*) Corresponding Author

Received: 15 Feb 2013, Accepted: 25 Mar 2013, Published: 30 Jun 2013

Abstract

In this study, we report the synthesis of some new Schiff base compounds (1-5) from the reaction of amoxicillin with some aromatic aldehydes in classical Schiff base method. These derivatives were characterized by melting point, elemental analysis, FT-IR and ¹H NMR data. All the synthesized compounds were evaluated in vitro for their antibacterial activities against two Gram positive (Staphylococcus aureus, Streptococcus faecalis) and two Gram negative (Escherichia coli, Pseudomonas aeruginosa) microorganisms in different concentrations (10^-1, 10^-3, 10^-5 and 10^-7 M) by agar diffusion disk method. The results showed that some of these derivatives have good antibacterial activities compared to biological activity of parent drug.

Keywords

Schiff base; Amoxicillin; Penicillin A; Azomethine; Imine derivatives; Antibacterial activity

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DOI: 10.5155/eurjchem.4.2.153-156.751

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Citations

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DOI: 10.1021/acs.oprd.7b00250

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How to cite

Tomi, I.; Abdullah, A.; Al-Daraji, A.; Abbass, S. Eur. J. Chem. 2013, 4(2), 153-156. doi:10.5155/eurjchem.4.2.153-156.751

Tomi, I.; Abdullah, A.; Al-Daraji, A.; Abbass, S. Synthesis, characterization and comparative study the antibacterial activities of some imine-amoxicillin derivatives. Eur. J. Chem. 2013, 4(2), 153-156. doi:10.5155/eurjchem.4.2.153-156.751

Tomi, I., Abdullah, A., Al-Daraji, A., & Abbass, S. (2013). Synthesis, characterization and comparative study the antibacterial activities of some imine-amoxicillin derivatives. European Journal of Chemistry, 4(2), 153-156. doi:10.5155/eurjchem.4.2.153-156.751

Tomi, Ivan, Amer Hasan Abdullah, Ali Hussein Raheemah Al-Daraji, & Selma Abdul Rudha Abbass. "Synthesis, characterization and comparative study the antibacterial activities of some imine-amoxicillin derivatives." European Journal of Chemistry [Online], 4.2 (2013): 153-156. Web. 23 Oct. 2019

Tomi, Ivan, Abdullah, Amer, Al-Daraji, Ali, AND Abbass, Selma. "Synthesis, characterization and comparative study the antibacterial activities of some imine-amoxicillin derivatives" European Journal of Chemistry [Online], Volume 4 Number 2 (30 June 2013)

DOI Link: https://doi.org/10.5155/eurjchem.4.2.153-156.751

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