European Journal of Chemistry

Synthesis, characterization and comparative study the antibacterial activities of some imine-amoxicillin derivatives

Article Sidebar

PDF
Published: Jun 30, 2013
DOI: https://doi.org/10.5155/eurjchem.4.2.153-156.751
Keywords:
Schiff base, Amoxicillin, Penicillin A, Azomethine, Imine derivatives, Antibacterial activity
Section
Research Article
Issue
Vol. 4 No. 2 (2013): June 2013
Dates
Received 2013-02-15
Accepted 2013-03-25
Published 2013-06-30


Main Article Content

Ivan Hameed Rouil Tomi
Department of Chemistry, College of Sciences, Al-Mustansiriya University, 10052, Baghdad, Iraq
Amer Hasan Abdullah
Department of Chemistry, College of Sciences, Al-Mustansiriya University, 10052, Baghdad, Iraq
Ali Hussein Raheemah Al-Daraji
Department of Chemistry, College of Sciences, Al-Mustansiriya University, 10052, Baghdad, Iraq
Selma Abdul Rudha Abbass
Department of Chemistry, College of Sciences, Al-Mustansiriya University, 10052, Baghdad, Iraq

Abstract

In this study, we report the synthesis of some new Schiff base compounds (1-5) from the reaction of amoxicillin with some aromatic aldehydes in classical Schiff base method. These derivatives were characterized by melting point, elemental analysis, FT-IR and 1H NMR data. All the synthesized compounds were evaluated in vitro for their antibacterial activities against two Gram positive (Staphylococcus aureus, Streptococcus faecalis) and two Gram negative (Escherichia coli, Pseudomonas aeruginosa) microorganisms in different concentrations (10-1, 10-3, 10-5 and 10-7 M) by agar diffusion disk method. The results showed that some of these derivatives have good antibacterial activities compared to biological activity of parent drug.

4_2_153_156

icon graph This Abstract was viewed 2588 times | icon graph Article PDF downloaded 1351 times

How to Cite
(1)
Tomi, I. H. R.; Abdullah, A. H.; Al-Daraji, A. H. R.; Abbass, S. A. R. Synthesis, Characterization and Comparative Study the Antibacterial Activities of Some Imine-Amoxicillin Derivatives. Eur. J. Chem. 2013, 4, 153-156.

Article Details

Share
Links for Article


Crossref - Scopus - Google - European PMC
Crossref
Scopus
Google Scholar
Europe PMC
References

[1]. Unal, A.; Palabiyik, L.; Karacan, E.; Onur, F. Turk. Pharm. Sci. 2008, 5, 1-16.

[2]. Bisson-Boutelliez, C.; Fontanay, S.; Finance, C., Kedzierewicz, F. AAPS Pharm. Sci. Tech. 2010, 11, 574-581.
http://dx.doi.org/10.1208/s12249-010-9412-1
PMid:20352533 PMCid:2902304

[3]. Jodeh, S.; Stati, H.; Haddad, M.; Renno, T.; Zaid, A.; Jaradat, N.; Kharoaf, M. Eur. J. Chem. 2012, 3(4), 480-484.
http://dx.doi.org/10.5155/eurjchem.3.4.480-484.698

[4]. Jodeh, S. Eur. J. Chem. 2012, 3(4), 468-474.
http://dx.doi.org/10.5155/eurjchem.3.4.468-474.706

[5]. Sivakumar, R.; Pradeepchandran, R. V.; Jayaveera, K. N. Eur. J. Chem. 2011, 2(4), 558-560.
http://dx.doi.org/10.5155/eurjchem.2.4.558-560.275

[6]. El-Sawi, E. A.; Mostafa, T. B.; Radwan, H. A. Eur. J. Chem. 2011, 2(4), 539-543.
http://dx.doi.org/10.5155/eurjchem.2.4.539-543.55

[7]. Imran, M.; Iqbal, J.; Iqbal, S.; Ijaz, N. Turk. J. Biol. 2007, 31, 67-72.

[8]. Parekh, H. M.; Patel, M. N. Russian J. Coord. Chem. 2006, 32, 431-436.
http://dx.doi.org/10.1134/S1070328406060066

[9]. Singh, K.; Barwa, M. S.; Tyagi, P. Eur. J. Med. Chem. 2007, 42, 394-402.
http://dx.doi.org/10.1016/j.ejmech.2006.10.016
PMid:17224205

[10]. Bagihalli, G. B.; Avaji, P. G.; Patil, S. A.; Badami, P. S. Eur. J. Med. Chem. 2008, 43, 2639-2649.
http://dx.doi.org/10.1016/j.ejmech.2008.02.013
PMid:18395942

[11]. Naz, N.; Iqbal, M. Z. J. Chem. Soc. Pak. 2009, 31, 440-446.

[12]. Joshi, S.; Pawar, V.; Uma, V. Int. J. Pharm. Bio Sci. 2011, 2, 240-250.

[13]. Al-Garawi, Z. S. M.; Tomi, I. H. R.; Al-Daraji, A. H. R. E-Journal Chem. 2012, 9(2), 962-969.
http://dx.doi.org/10.1155/2012/218675

[14]. Tomi, I. H. R.; Al-Daraji, A. H. R.; Al-Qaysi, R. R. T.; Hasson, M. M.; Al-Dulaimy, K. H. Arabian J. Chem. 2011 http://dx.doi.org/10.1016/ j.arabjc.2010.12.003

[15]. Panda, S. S.; Chowdary. P.; Jayashree, B. S. Indian J. Pharm. Sci. 2009, 71(6), 684-687.
http://dx.doi.org/10.4103/0250-474X.59554
PMid:20376225 PMCid:2846477

[16]. Branch, S. K.; Casy, A. F.; Lipczynsky, A.; Ominde, E. M. A. Magn. Reson. Chem. 1986, 24, 465-479.
http://dx.doi.org/10.1002/mrc.1260240602

[17]. Branch, S. K.; Casy, A. F.; Ominde, E. M. A. J. Pharm. Biomed. Anal. 1987, 5, 73-103.
http://dx.doi.org/10.1016/0731-7085(87)80011-0

[18]. Kupka, T.; Dziegielewski, J. O.; Pasterna, G. J. Pharm. Biomed. Anal. 1993, 11, 103-116.
http://dx.doi.org/10.1016/0731-7085(93)80130-S

[19]. Stefano, R. D.; Scopelliti, M.; Pellerito, C.; Fiore, T.; Vitturi, R.; Colomba, M. S.; Gianguzza, P.; Stocco, G. C.; Consiglio, M.; Pellerito, L. J. Inorg. Biochem. 2002, 89, 279-292.
http://dx.doi.org/10.1016/S0162-0134(02)00366-5

Supporting Agencies

Most read articles by the same author(s)
TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2025 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).