European Journal of Chemistry 2013, 4(2), 153-156. doi:10.5155/eurjchem.4.2.153-156.751

Synthesis, characterization and comparative study the antibacterial activities of some imine-amoxicillin derivatives


Ivan Hameed Rouil Tomi (1,*) , Amer Hasan Abdullah (2) , Ali Hussein Raheemah Al-Daraji (3) , Selma Abdul Rudha Abbass (4)

(1) Department of Chemistry, College of Sciences, Al-Mustansiriya University, 10052, Baghdad, Iraq
(2) Department of Chemistry, College of Sciences, Al-Mustansiriya University, 10052, Baghdad, Iraq
(3) Department of Chemistry, College of Sciences, Al-Mustansiriya University, 10052, Baghdad, Iraq
(4) Department of Chemistry, College of Sciences, Al-Mustansiriya University, 10052, Baghdad, Iraq
(*) Corresponding Author

Received: 15 Feb 2013, Accepted: 25 Mar 2013, Published: 30 Jun 2013

Abstract


In this study, we report the synthesis of some new Schiff base compounds (1-5) from the reaction of amoxicillin with some aromatic aldehydes in classical Schiff base method. These derivatives were characterized by melting point, elemental analysis, FT-IR and 1H NMR data. All the synthesized compounds were evaluated in vitro for their antibacterial activities against two Gram positive (Staphylococcus aureus, Streptococcus faecalis) and two Gram negative (Escherichia coli, Pseudomonas aeruginosa) microorganisms in different concentrations (10-1, 10-3, 10-5 and 10-7 M) by agar diffusion disk method. The results showed that some of these derivatives have good antibacterial activities compared to biological activity of parent drug.

4_2_153_156

Keywords


Schiff base; Amoxicillin; Penicillin A; Azomethine; Imine derivatives; Antibacterial activity

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DOI: 10.5155/eurjchem.4.2.153-156.751

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How to cite


Tomi, I.; Abdullah, A.; Al-Daraji, A.; Abbass, S. Eur. J. Chem. 2013, 4(2), 153-156. doi:10.5155/eurjchem.4.2.153-156.751
Tomi, I.; Abdullah, A.; Al-Daraji, A.; Abbass, S. Synthesis, characterization and comparative study the antibacterial activities of some imine-amoxicillin derivatives. Eur. J. Chem. 2013, 4(2), 153-156. doi:10.5155/eurjchem.4.2.153-156.751
Tomi, I., Abdullah, A., Al-Daraji, A., & Abbass, S. (2013). Synthesis, characterization and comparative study the antibacterial activities of some imine-amoxicillin derivatives. European Journal of Chemistry, 4(2), 153-156. doi:10.5155/eurjchem.4.2.153-156.751
Tomi, Ivan, Amer Hasan Abdullah, Ali Hussein Raheemah Al-Daraji, & Selma Abdul Rudha Abbass. "Synthesis, characterization and comparative study the antibacterial activities of some imine-amoxicillin derivatives." European Journal of Chemistry [Online], 4.2 (2013): 153-156. Web. 23 Oct. 2019
Tomi, Ivan, Abdullah, Amer, Al-Daraji, Ali, AND Abbass, Selma. "Synthesis, characterization and comparative study the antibacterial activities of some imine-amoxicillin derivatives" European Journal of Chemistry [Online], Volume 4 Number 2 (30 June 2013)

DOI Link: https://doi.org/10.5155/eurjchem.4.2.153-156.751

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