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Synthesis, characterization and comparative study the antibacterial activities of some imine-amoxicillin derivatives
Ivan Hameed Rouil Tomi (1,*)
, Amer Hasan Abdullah (2) , Ali Hussein Raheemah Al-Daraji (3) , Selma Abdul Rudha Abbass (4) (1) Department of Chemistry, College of Sciences, Al-Mustansiriya University, 10052, Baghdad, Iraq
(2) Department of Chemistry, College of Sciences, Al-Mustansiriya University, 10052, Baghdad, Iraq
(3) Department of Chemistry, College of Sciences, Al-Mustansiriya University, 10052, Baghdad, Iraq
(4) Department of Chemistry, College of Sciences, Al-Mustansiriya University, 10052, Baghdad, Iraq
(*) Corresponding Author
Received: 15 Feb 2013 | Revised: 22 Mar 2013 | Accepted: 25 Mar 2013 | Published: 30 Jun 2013 | Issue Date: June 2013
Abstract
In this study, we report the synthesis of some new Schiff base compounds (1-5) from the reaction of amoxicillin with some aromatic aldehydes in classical Schiff base method. These derivatives were characterized by melting point, elemental analysis, FT-IR and 1H NMR data. All the synthesized compounds were evaluated in vitro for their antibacterial activities against two Gram positive (Staphylococcus aureus, Streptococcus faecalis) and two Gram negative (Escherichia coli, Pseudomonas aeruginosa) microorganisms in different concentrations (10-1, 10-3, 10-5 and 10-7 M) by agar diffusion disk method. The results showed that some of these derivatives have good antibacterial activities compared to biological activity of parent drug.
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DOI: 10.5155/eurjchem.4.2.153-156.751
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References
[1]. Unal, A.; Palabiyik, L.; Karacan, E.; Onur, F. Turk. Pharm. Sci. 2008, 5, 1-16.
[2]. Bisson-Boutelliez, C.; Fontanay, S.; Finance, C., Kedzierewicz, F. AAPS Pharm. Sci. Tech. 2010, 11, 574-581.
http://dx.doi.org/10.1208/s12249-010-9412-1
PMid:20352533 PMCid:2902304
[3]. Jodeh, S.; Stati, H.; Haddad, M.; Renno, T.; Zaid, A.; Jaradat, N.; Kharoaf, M. Eur. J. Chem. 2012, 3(4), 480-484.
http://dx.doi.org/10.5155/eurjchem.3.4.480-484.698
[4]. Jodeh, S. Eur. J. Chem. 2012, 3(4), 468-474.
http://dx.doi.org/10.5155/eurjchem.3.4.468-474.706
[5]. Sivakumar, R.; Pradeepchandran, R. V.; Jayaveera, K. N. Eur. J. Chem. 2011, 2(4), 558-560.
http://dx.doi.org/10.5155/eurjchem.2.4.558-560.275
[6]. El-Sawi, E. A.; Mostafa, T. B.; Radwan, H. A. Eur. J. Chem. 2011, 2(4), 539-543.
http://dx.doi.org/10.5155/eurjchem.2.4.539-543.55
[7]. Imran, M.; Iqbal, J.; Iqbal, S.; Ijaz, N. Turk. J. Biol. 2007, 31, 67-72.
[8]. Parekh, H. M.; Patel, M. N. Russian J. Coord. Chem. 2006, 32, 431-436.
http://dx.doi.org/10.1134/S1070328406060066
[9]. Singh, K.; Barwa, M. S.; Tyagi, P. Eur. J. Med. Chem. 2007, 42, 394-402.
http://dx.doi.org/10.1016/j.ejmech.2006.10.016
PMid:17224205
[10]. Bagihalli, G. B.; Avaji, P. G.; Patil, S. A.; Badami, P. S. Eur. J. Med. Chem. 2008, 43, 2639-2649.
http://dx.doi.org/10.1016/j.ejmech.2008.02.013
PMid:18395942
[11]. Naz, N.; Iqbal, M. Z. J. Chem. Soc. Pak. 2009, 31, 440-446.
[12]. Joshi, S.; Pawar, V.; Uma, V. Int. J. Pharm. Bio Sci. 2011, 2, 240-250.
[13]. Al-Garawi, Z. S. M.; Tomi, I. H. R.; Al-Daraji, A. H. R. E-Journal Chem. 2012, 9(2), 962-969.
http://dx.doi.org/10.1155/2012/218675
[14]. Tomi, I. H. R.; Al-Daraji, A. H. R.; Al-Qaysi, R. R. T.; Hasson, M. M.; Al-Dulaimy, K. H. Arabian J. Chem. 2011 http://dx.doi.org/10.1016/ j.arabjc.2010.12.003
[15]. Panda, S. S.; Chowdary. P.; Jayashree, B. S. Indian J. Pharm. Sci. 2009, 71(6), 684-687.
http://dx.doi.org/10.4103/0250-474X.59554
PMid:20376225 PMCid:2846477
[16]. Branch, S. K.; Casy, A. F.; Lipczynsky, A.; Ominde, E. M. A. Magn. Reson. Chem. 1986, 24, 465-479.
http://dx.doi.org/10.1002/mrc.1260240602
[17]. Branch, S. K.; Casy, A. F.; Ominde, E. M. A. J. Pharm. Biomed. Anal. 1987, 5, 73-103.
http://dx.doi.org/10.1016/0731-7085(87)80011-0
[18]. Kupka, T.; Dziegielewski, J. O.; Pasterna, G. J. Pharm. Biomed. Anal. 1993, 11, 103-116.
http://dx.doi.org/10.1016/0731-7085(93)80130-S
[19]. Stefano, R. D.; Scopelliti, M.; Pellerito, C.; Fiore, T.; Vitturi, R.; Colomba, M. S.; Gianguzza, P.; Stocco, G. C.; Consiglio, M.; Pellerito, L. J. Inorg. Biochem. 2002, 89, 279-292.
http://dx.doi.org/10.1016/S0162-0134(02)00366-5
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DOI Link: https://doi.org/10.5155/eurjchem.4.2.153-156.751
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European Journal of Chemistry 2013, 4(2), 153-156 | doi: https://doi.org/10.5155/eurjchem.4.2.153-156.751 | Get rights and content
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