European Journal of Chemistry 2013, 4(3), 207-210 | doi: https://doi.org/10.5155/eurjchem.4.3.207-210.780 | Get rights and content

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Synthesis, characterization and antibacterial activity of (E)-chalcone derivatives


Ahmed Mutanabbi Abdula (1,*)

(1) Chemistry Department, College of Science, Al-Mustansiriyah University, Baghdad, 00964, Iraq
(*) Corresponding Author

Received: 23 Mar 2013 | Revised: 23 Apr 2013 | Accepted: 23 Apr 2013 | Published: 30 Sep 2013 | Issue Date: September 2013

Abstract


(E)-Chalcone derivatives were synthesized by the Claisen-Schmidt condensation of aromatic aldehydes with methyl ketones. 5-Arylfuran-2-carboxaldehydes (1a-b) were synthesized by Meerwein´s method and condensed with 2-acetylpyrole or 2-acetylfuran to produce the new chalcone derivatives (2a-d). The new chalcones were characterized using FT-IR and GC-MS. The synthesized compounds were also screened against some bacterial species to evaluate their activity as promising antibacterial agents.

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Keywords


Furan derivatives; Meerwein's reaction; Chalcone derivatives; Antibacterial activity; Claisen-Schmidt condensation; 1,3-Diphenyl-2-propen-1-ones

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DOI: 10.5155/eurjchem.4.3.207-210.780

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Funding information


Chemistry Department, College of Science, Al-Mustansiriyah University, Baghdad, Iraq

Citations

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[1]. Venkatakrishna Manikala, V. Madhusudhan Rao
Synthesis and biological evaluation of chalcone tethered quinoline derivatives as anticancer agents
Chemical Data Collections  28, 100423, 2020
DOI: 10.1016/j.cdc.2020.100423
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[2]. Gayathri Rajendran, Deepu Bhanu, Baladhandapani Aruchamy, Prasanna Ramani, Nanjan Pandurangan, Kondapa Naidu Bobba, Eun Jung Oh, Ho Yun Chung, Prakash Gangadaran, Byeong-Cheol Ahn
Chalcone: A Promising Bioactive Scaffold in Medicinal Chemistry
Pharmaceuticals  15(10), 1250, 2022
DOI: 10.3390/ph15101250
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[3]. Ahmed Kamal, Vangala Santhosh Reddy, Karnewar Santosh, G. Bharath Kumar, Anver Basha Shaik, Rasala Mahesh, Sumit. S. Chourasiya, Ibrahim Bin Sayeed, Srigiridhar Kotamraju
Synthesis of imidazo[2,1-b][1,3,4]thiadiazole–chalcones as apoptosis inducing anticancer agents
Med. Chem. Commun.  5(11), 1718, 2014
DOI: 10.1039/C4MD00228H
/


[4]. Veera venkatarao, Lav Kumar, Anjali Jha, Gattu Sridhar
Synthesis and biological evaluation of chalcone fused quinoline derivatives as anticancer agents
Chemical Data Collections  22, 100236, 2019
DOI: 10.1016/j.cdc.2019.100236
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[5]. Bathélémy Ngameni, Musa Erdoğan, Victor Kuete, Erdin Dalkılıç, Bonaventure T Ngadjui, Arif Daştan
Synthesis and structural characterization of novel O-substituted phenolic and chalcone derivatives with antioxidant activity
Journal of Chemical Research  45(1-2), 159, 2021
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How to cite


Abdula, A. Eur. J. Chem. 2013, 4(3), 207-210. doi:10.5155/eurjchem.4.3.207-210.780
Abdula, A. Synthesis, characterization and antibacterial activity of (E)-chalcone derivatives. Eur. J. Chem. 2013, 4(3), 207-210. doi:10.5155/eurjchem.4.3.207-210.780
Abdula, A. (2013). Synthesis, characterization and antibacterial activity of (E)-chalcone derivatives. European Journal of Chemistry, 4(3), 207-210. doi:10.5155/eurjchem.4.3.207-210.780
Abdula, Ahmed. "Synthesis, characterization and antibacterial activity of (E)-chalcone derivatives." European Journal of Chemistry [Online], 4.3 (2013): 207-210. Web. 26 Nov. 2022
Abdula, Ahmed. "Synthesis, characterization and antibacterial activity of (E)-chalcone derivatives" European Journal of Chemistry [Online], Volume 4 Number 3 (30 September 2013)

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European Journal of Chemistry 2013, 4(3), 207-210 | doi: https://doi.org/10.5155/eurjchem.4.3.207-210.780 | Get rights and content

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