European Journal of Chemistry 2013, 4(3), 207-210. doi:10.5155/eurjchem.4.3.207-210.780

Synthesis, characterization and antibacterial activity of (E)-chalcone derivatives


Ahmed Mutanabbi Abdula (1,*)

(1) Chemistry Department, College of Science, Al-Mustansiriyah University, Baghdad, 00964, Iraq
(*) Corresponding Author

Received: 23 Mar 2013, Accepted: 23 Apr 2013, Published: 30 Sep 2013

Abstract


(E)-Chalcone derivatives were synthesized by the Claisen-Schmidt condensation of aromatic aldehydes with methyl ketones. 5-Arylfuran-2-carboxaldehydes (1a-b) were synthesized by Meerwein´s method and condensed with 2-acetylpyrole or 2-acetylfuran to produce the new chalcone derivatives (2a-d). The new chalcones were characterized using FT-IR and GC-MS. The synthesized compounds were also screened against some bacterial species to evaluate their activity as promising antibacterial agents.

4_3_207_210

Keywords


Furan derivatives; Meerwein's reaction; Chalcone derivatives; Antibacterial activity; Claisen-Schmidt condensation; 1,3-Diphenyl-2-propen-1-ones

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DOI: 10.5155/eurjchem.4.3.207-210.780

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References

[1]. Kumar, S. K.; Hager, E.; Pettit, C.; Gurulingappa, H.; Davidson, N. E.; Khan, S. R. J. Med. Chem. 2003, 46, 2813-2815.
http://dx.doi.org/10.1021/jm030213+
PMid:12825923

[2]. Hsieh, H. K.; Lee, T. H.; Wang, J. P.; Wang, J. J.; Lin, C. N. Pharm. Res. 1998, 15(1), 39-46.
http://dx.doi.org/10.1023/A:1011940401754
PMid:9487544

[3]. Murakami, S.; Muramatsu, M.; Aihara, H.; Otomo, S. Biochem. Pharmacol. 1991, 42(7), 1447-1451.
http://dx.doi.org/10.1016/0006-2952(91)90458-H

[4]. Viana, G. S.; Bandeira, M. A.; Matos, F. J. Phytomedicine 2003, 10(2), 189-195.
http://dx.doi.org/10.1078/094471103321659924
PMid:12725575

[5]. Wu, J. H.; Wang, X. H.; Yi, Y. H.; Lee, K. H. Bioorg. Med. Chem. Lett. 2003, 13(10), 1813-1815.
http://dx.doi.org/10.1016/S0960-894X(03)00197-5

[6]. Lopez, S. N.; Castelli, M. V.; Zacchino, S. A.; Dominguez, J. N.; Lobo, G.; Cortes, J. C.; Ribas, J. C.; Devia, C.; Rodriguez, A. M.; Enriz, R. D. Bioorg. Med. Chem. 2001, 9(8), 1999-2004.
http://dx.doi.org/10.1016/S0968-0896(01)00116-X

[7]. Liu, M.; Go, P.; Wilairat, M. L. J. Med. Chem. 2001, 44(25), 4443-4452.
http://dx.doi.org/10.1021/jm0101747

[8]. Bekhit, A. A.; Habib, N. S.; Bekhit, A. Boll. Chim. Farm. 2001, 140(5), 297-301.
PMid:11680081

[9]. Puterova, Z.; Krutosikova, A.; Lycka, A.; Durcekova, T. Molecules 2004, 9, 241-255.
http://dx.doi.org/10.3390/90400241
PMid:18007428

[10]. Puterova. Z.; Sterk, H.; Krutosikova, A. Molecules 2004, 9(1), 11-21.
PMid:18007407

[11]. Basaif, S. A.; Sobahi, T. R.; Khalil, A. K.; Hassan, M. A. Bull. Korean Chem. Soc. 2005, 26 (11), 1677-1681.
http://dx.doi.org/10.5012/bkcs.2005.26.11.1677

[12]. Radwan, M. A. A.; Abbas, E. M. H. Monatsh. Chem. 2009. 140 (2), 229-233.
http://dx.doi.org/10.1007/s00706-008-0061-y

[13]. Yadav, N.; Dixit, S. K.; Bhattacharya, A.; Mishra, L. C.; Sharma, M.; Awasthi, S. K.; Bhasin, V. K. Chem. Biol. Drug Des. 2012, 80(2), 340-347.
http://dx.doi.org/10.1111/j.1747-0285.2012.01383.x
PMid:22429524

[14]. Sid, A.; Lamara, K.; Mokhtari, M.; Ziani, N.; Mosset, P. Eur. J. Chem. 2011, 2(3) 311‐313.
http://dx.doi.org/10.5155/eurjchem.2.3.311-313.414

[15]. Tomi, I. H. R.; Al-Daraji, A. H. R.; Al-Qaysi, R. R. T.; Hasson, M. M.; Al-Dulaimy, K. H. D. Arab. J. Chem. 2010. doi:10.1016/j.arabjc.2010.12.003. In press.
http://dx.doi.org/10.1016/j.arabjc.2010.12.003


How to cite


Abdula, A. Eur. J. Chem. 2013, 4(3), 207-210. doi:10.5155/eurjchem.4.3.207-210.780
Abdula, A. Synthesis, characterization and antibacterial activity of (E)-chalcone derivatives. Eur. J. Chem. 2013, 4(3), 207-210. doi:10.5155/eurjchem.4.3.207-210.780
Abdula, A. (2013). Synthesis, characterization and antibacterial activity of (E)-chalcone derivatives. European Journal of Chemistry, 4(3), 207-210. doi:10.5155/eurjchem.4.3.207-210.780
Abdula, Ahmed. "Synthesis, characterization and antibacterial activity of (E)-chalcone derivatives." European Journal of Chemistry [Online], 4.3 (2013): 207-210. Web. 21 Oct. 2019
Abdula, Ahmed. "Synthesis, characterization and antibacterial activity of (E)-chalcone derivatives" European Journal of Chemistry [Online], Volume 4 Number 3 (30 September 2013)

DOI Link: https://doi.org/10.5155/eurjchem.4.3.207-210.780

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