Email this article 
Hide
Show all
OPEN ACCESS | 
PEER-REVIEWED |
RESEARCH ARTICLE
|
DOWNLOAD PDF
|
VIEW FULL-TEXT PDF
| TOTAL VIEWS
Synthesis, characterization and antibacterial activity of (E)-chalcone derivatives
Ahmed Mutanabbi Abdula (1,*)
(1) Chemistry Department, College of Science, Al-Mustansiriyah University, Baghdad, 00964, Iraq
(*) Corresponding Author
Received: 23 Mar 2013 | Revised: 23 Apr 2013 | Accepted: 23 Apr 2013 | Published: 30 Sep 2013 | Issue Date: September 2013
Abstract
(E)-Chalcone derivatives were synthesized by the Claisen-Schmidt condensation of aromatic aldehydes with methyl ketones. 5-Arylfuran-2-carboxaldehydes (1a-b) were synthesized by Meerwein´s method and condensed with 2-acetylpyrole or 2-acetylfuran to produce the new chalcone derivatives (2a-d). The new chalcones were characterized using FT-IR and GC-MS. The synthesized compounds were also screened against some bacterial species to evaluate their activity as promising antibacterial agents.
Announcements
One of our sponsors will cover the article processing fee for all submissions made between May 17, 2023 and June 16, 2023 (Voucher code: SPONSOR2023).
Editor-in-Chief
European Journal of Chemistry
Keywords
Full Text:
PDF
DOI: 10.5155/eurjchem.4.3.207-210.780
Links for Article
| | | | | | |
| | | | | | |
| | | |
Related Articles
Article Metrics
This Abstract was viewed 2956 times |
PDF Article downloaded 1084 times
Funding information
Chemistry Department, College of Science, Al-Mustansiriyah University, Baghdad, Iraq
Citations
[1]. Venkatakrishna Manikala, V. Madhusudhan Rao
Synthesis and biological evaluation of chalcone tethered quinoline derivatives as anticancer agents
Chemical Data Collections 28, 100423, 2020
DOI: 10.1016/j.cdc.2020.100423
[2]. Gayathri Rajendran, Deepu Bhanu, Baladhandapani Aruchamy, Prasanna Ramani, Nanjan Pandurangan, Kondapa Naidu Bobba, Eun Jung Oh, Ho Yun Chung, Prakash Gangadaran, Byeong-Cheol Ahn
Chalcone: A Promising Bioactive Scaffold in Medicinal Chemistry
Pharmaceuticals 15(10), 1250, 2022
DOI: 10.3390/ph15101250
[3]. Ahmed Kamal, Vangala Santhosh Reddy, Karnewar Santosh, G. Bharath Kumar, Anver Basha Shaik, Rasala Mahesh, Sumit. S. Chourasiya, Ibrahim Bin Sayeed, Srigiridhar Kotamraju
Synthesis of imidazo[2,1-b][1,3,4]thiadiazole–chalcones as apoptosis inducing anticancer agents
Med. Chem. Commun. 5(11), 1718, 2014
DOI: 10.1039/C4MD00228H
[4]. Veera venkatarao, Lav Kumar, Anjali Jha, Gattu Sridhar
Synthesis and biological evaluation of chalcone fused quinoline derivatives as anticancer agents
Chemical Data Collections 22, 100236, 2019
DOI: 10.1016/j.cdc.2019.100236
[5]. Bathélémy Ngameni, Musa Erdoğan, Victor Kuete, Erdin Dalkılıç, Bonaventure T Ngadjui, Arif Daştan
Synthesis and structural characterization of novel O-substituted phenolic and chalcone derivatives with antioxidant activity
Journal of Chemical Research 45(1-2), 159, 2021
DOI: 10.1177/1747519820932789
References
[1]. Kumar, S. K.; Hager, E.; Pettit, C.; Gurulingappa, H.; Davidson, N. E.; Khan, S. R. J. Med. Chem. 2003, 46, 2813-2815.
http://dx.doi.org/10.1021/jm030213+
PMid:12825923
[2]. Hsieh, H. K.; Lee, T. H.; Wang, J. P.; Wang, J. J.; Lin, C. N. Pharm. Res. 1998, 15(1), 39-46.
http://dx.doi.org/10.1023/A:1011940401754
PMid:9487544
[3]. Murakami, S.; Muramatsu, M.; Aihara, H.; Otomo, S. Biochem. Pharmacol. 1991, 42(7), 1447-1451.
http://dx.doi.org/10.1016/0006-2952(91)90458-H
[4]. Viana, G. S.; Bandeira, M. A.; Matos, F. J. Phytomedicine 2003, 10(2), 189-195.
http://dx.doi.org/10.1078/094471103321659924
PMid:12725575
[5]. Wu, J. H.; Wang, X. H.; Yi, Y. H.; Lee, K. H. Bioorg. Med. Chem. Lett. 2003, 13(10), 1813-1815.
http://dx.doi.org/10.1016/S0960-894X(03)00197-5
[6]. Lopez, S. N.; Castelli, M. V.; Zacchino, S. A.; Dominguez, J. N.; Lobo, G.; Cortes, J. C.; Ribas, J. C.; Devia, C.; Rodriguez, A. M.; Enriz, R. D. Bioorg. Med. Chem. 2001, 9(8), 1999-2004.
http://dx.doi.org/10.1016/S0968-0896(01)00116-X
[7]. Liu, M.; Go, P.; Wilairat, M. L. J. Med. Chem. 2001, 44(25), 4443-4452.
http://dx.doi.org/10.1021/jm0101747
[8]. Bekhit, A. A.; Habib, N. S.; Bekhit, A. Boll. Chim. Farm. 2001, 140(5), 297-301.
PMid:11680081
[9]. Puterova, Z.; Krutosikova, A.; Lycka, A.; Durcekova, T. Molecules 2004, 9, 241-255.
http://dx.doi.org/10.3390/90400241
PMid:18007428
[10]. Puterova. Z.; Sterk, H.; Krutosikova, A. Molecules 2004, 9(1), 11-21.
PMid:18007407
[11]. Basaif, S. A.; Sobahi, T. R.; Khalil, A. K.; Hassan, M. A. Bull. Korean Chem. Soc. 2005, 26 (11), 1677-1681.
http://dx.doi.org/10.5012/bkcs.2005.26.11.1677
[12]. Radwan, M. A. A.; Abbas, E. M. H. Monatsh. Chem. 2009. 140 (2), 229-233.
http://dx.doi.org/10.1007/s00706-008-0061-y
[13]. Yadav, N.; Dixit, S. K.; Bhattacharya, A.; Mishra, L. C.; Sharma, M.; Awasthi, S. K.; Bhasin, V. K. Chem. Biol. Drug Des. 2012, 80(2), 340-347.
http://dx.doi.org/10.1111/j.1747-0285.2012.01383.x
PMid:22429524
[14]. Sid, A.; Lamara, K.; Mokhtari, M.; Ziani, N.; Mosset, P. Eur. J. Chem. 2011, 2(3) 311‐313.
http://dx.doi.org/10.5155/eurjchem.2.3.311-313.414
[15]. Tomi, I. H. R.; Al-Daraji, A. H. R.; Al-Qaysi, R. R. T.; Hasson, M. M.; Al-Dulaimy, K. H. D. Arab. J. Chem. 2010. doi:10.1016/j.arabjc.2010.12.003. In press.
http://dx.doi.org/10.1016/j.arabjc.2010.12.003
How to cite
The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item
DOI Link: https://doi.org/10.5155/eurjchem.4.3.207-210.780
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
Save to Zotero
Save to Mendeley
European Journal of Chemistry 2013, 4(3), 207-210 | doi: https://doi.org/10.5155/eurjchem.4.3.207-210.780 | Get rights and content
Refbacks
- There are currently no refbacks.
Copyright (c)
© Copyright 2010 - 2023 • Atlanta Publishing House LLC • All Right Reserved.
The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.
Copyright 2010-2023 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.