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Synthesis, characterization and antibacterial activity of (E)-chalcone derivatives
Ahmed Mutanabbi Abdula (1,*)
(1) Chemistry Department, College of Science, Al-Mustansiriyah University, Baghdad, 00964, Iraq
(*) Corresponding Author
Received: 23 Mar 2013 | Revised: 23 Apr 2013 | Accepted: 23 Apr 2013 | Published: 30 Sep 2013 | Issue Date: September 2013
Abstract
(E)-Chalcone derivatives were synthesized by the Claisen-Schmidt condensation of aromatic aldehydes with methyl ketones. 5-Arylfuran-2-carboxaldehydes (1a-b) were synthesized by Meerwein´s method and condensed with 2-acetylpyrole or 2-acetylfuran to produce the new chalcone derivatives (2a-d). The new chalcones were characterized using FT-IR and GC-MS. The synthesized compounds were also screened against some bacterial species to evaluate their activity as promising antibacterial agents.
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DOI: 10.5155/eurjchem.4.3.207-210.780
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Chemistry Department, College of Science, Al-Mustansiriyah University, Baghdad, Iraq
Citations
[1]. Venkatakrishna Manikala, V. Madhusudhan Rao
Synthesis and biological evaluation of chalcone tethered quinoline derivatives as anticancer agents
Chemical Data Collections 28, 100423, 2020
DOI: 10.1016/j.cdc.2020.100423
[2]. Gayathri Rajendran, Deepu Bhanu, Baladhandapani Aruchamy, Prasanna Ramani, Nanjan Pandurangan, Kondapa Naidu Bobba, Eun Jung Oh, Ho Yun Chung, Prakash Gangadaran, Byeong-Cheol Ahn
Chalcone: A Promising Bioactive Scaffold in Medicinal Chemistry
Pharmaceuticals 15(10), 1250, 2022
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Synthesis of imidazo[2,1-b][1,3,4]thiadiazole–chalcones as apoptosis inducing anticancer agents
Med. Chem. Commun. 5(11), 1718, 2014
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Synthesis and biological evaluation of chalcone fused quinoline derivatives as anticancer agents
Chemical Data Collections 22, 100236, 2019
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[5]. Bathélémy Ngameni, Musa Erdoğan, Victor Kuete, Erdin Dalkılıç, Bonaventure T Ngadjui, Arif Daştan
Synthesis and structural characterization of novel O-substituted phenolic and chalcone derivatives with antioxidant activity
Journal of Chemical Research 45(1-2), 159, 2021
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DOI Link: https://doi.org/10.5155/eurjchem.4.3.207-210.780
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European Journal of Chemistry 2013, 4(3), 207-210 | doi: https://doi.org/10.5155/eurjchem.4.3.207-210.780 | Get rights and content
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