European Journal of Chemistry 2013, 4(3), 235-239 | doi: | Get rights and content

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Synthesis and characterization of diaza analogues of podophyllotoxin

Yeriyur Basavaiah Basavaraju (1,*) , Basavaiah Umesha (2)

(1) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570006, Karnataka, India
(2) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570006, Karnataka, India
(*) Corresponding Author

Received: 23 Mar 2013 | Accepted: 07 May 2013 | Published: 30 Sep 2013 | Issue Date: September 2013


In an attempt to synthesize the novel diaza analogues of podophyllotoxin (7a-d) in five step reactions. The synthesis of title compounds has been achieved from tetralones, which were formylated with ethylformate; prepared via cyclization with hydrazine hydrate. Furthermore, these newly synthesized compounds were characterized by spectral and elemental analysis data.



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European Journal of Chemistry


Chalcones; Tetralones; Ethylformate; Sodium hydride; Hydrazine hydrate; Cyclopropyl ketones

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DOI: 10.5155/eurjchem.4.3.235-239.782

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Indian Institute of Technology, Bombay, India



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[3]. Kanakapura Narayanaramakrishna Padmavath, Yeriyuru Basavaiah Basavaraju, Basavaiah Umesha
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[1]. Shi-Wu, C.; Yun-Hua, W.; Yan, J.; Xuan, T.; Yong-Tang, Z.; Du-Qiang, L.; Yong-Qiang, T. Bioorg. Med. Chem. Lett. 2007, 17, 2091- 2095.

[2]. Mohammed, M. M. D.; Chen, M.; Zhai, L.; Ibrahim, N. A. Eur. J. Chem. 2010, 1(2), 110-114.

[3]. Zhu, X. K.; Guan, J.; Xiao, Z.; Cosentino, M.; Lee, K. H. Bioorg. Med. Chem. 2004, 12, 4267-4273.

[4]. Lee, K. H. ACS Symp. Ser. 1993, 170-190.

[5]. MacRae, W. D.; Hudson, J. B.; Towers, B. H. N. Planta Med. 1993, 55, 531-535.

[6]. Imbert, T. F. Biochimie. 1998, 80, 207-222.

[7]. Hemakumar, K. H.; Sathisha, A. D.; Basavaraju, Y. B. E-Journal Chem. 2008, 5, 114-119.

[8]. Jardine, I.; Carrady, J. M.; Dourous, J. D. Anticancer agents Based on Natural Product Models, Eds., Academic press, New York. 1980, pp. 319-351.

[9]. Lee, K. H.; Beers, S. A.; Mori, M.; Wang, Z. Q.; Kuo, Y. H.; Li, L.; Liu, S. Y.; Chang, J. Y.; Han, F. S.; Chang, Y. C. J. Med. Chem. 1990, 33, 1365-1368.

[10]. Stehlin, H.; Von Wartburg, A. Prog. Drug Res. 1989, 33, 169-266.

[11]. Ahmad, K.; Ashwin, K. B.; Paidakula, S.; Nagula, S.; Shiva, K. M. Bioorg. Med. Chem. Lett. 2011, 21, 350-353.

[12]. Kelly, M. G.; Hart Well, J. L. Natl. J. Cancer Ins. 1954, 14, 967-1010.

[13]. Furniss, B. S.; Hannaford, A. J.; Smith, P. W. G.; Tatchell, A. R. Vogels text book of practical organic chemistry, 5th edition, ELBS with Longman, 1989.

[14]. Rai, K. M. L.; Murthy, C. V.; Radhakrishna, P. M. Synthetic Comm. 1990, 20, 1273-1277.

[15]. Doyle, M. P.; Hu, W. Adv. Synth. Catal. 2001, 343, 299-302.<299::AID-ADSC299>3.0.CO;2-Y

[16]. Davies, H. M. L.; Calvo, R. L.; Townsend, R. J.; Ren, P.; Churchill, R. M. J. Org. Chem. 2000, 65, 4261-4268.

[17]. Sadashiva, M. B.; Basavaraju, Y. B. Bulg. Chem. Comm. 2005, 37, 135-139.

[18]. Anjana, M. C.; Basavaraju, Y. B. Ind. J. Hetero. Chem. 1998, 7, 177-180.

[19]. Padmavathi, V.; Mohan, R. B. J.; Balaiah, A.; Venugopal, R. K.; Bhaskar, R. D. Molecules. 2000, 5, 1281-1286.

How to cite

Basavaraju, Y.; Umesha, B. Eur. J. Chem. 2013, 4(3), 235-239. doi:10.5155/eurjchem.4.3.235-239.782
Basavaraju, Y.; Umesha, B. Synthesis and characterization of diaza analogues of podophyllotoxin. Eur. J. Chem. 2013, 4(3), 235-239. doi:10.5155/eurjchem.4.3.235-239.782
Basavaraju, Y., & Umesha, B. (2013). Synthesis and characterization of diaza analogues of podophyllotoxin. European Journal of Chemistry, 4(3), 235-239. doi:10.5155/eurjchem.4.3.235-239.782
Basavaraju, Yeriyur, & Basavaiah Umesha. "Synthesis and characterization of diaza analogues of podophyllotoxin." European Journal of Chemistry [Online], 4.3 (2013): 235-239. Web. 3 Jun. 2023
Basavaraju, Yeriyur, AND Umesha, Basavaiah. "Synthesis and characterization of diaza analogues of podophyllotoxin" European Journal of Chemistry [Online], Volume 4 Number 3 (30 September 2013)

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