European Journal of Chemistry

Green synthesis of novel pyrazole containing Schiff base derivatives as antibacterial agents on the bases of in-vitro and DFT



Main Article Content

Salman Ahmad Khan
Abdullah Mohamed Asiri
Abdulrhim Alabbas Basheike
Kamlesh Sharma

Abstract

A series of pyrazole containing Schiff bases were synthesized, by the reaction of 3,5-dimethyl-1-phenylpyrazole-4-carboxaldehyde and the corresponding active amines under microwave irradiation. The structures of the synthesized compounds were established by spectroscopic data (FT-IR, 1H NMR, 13C NMR and ESI-MS) and elemental analyses. The anti-bacterial activity of these compounds were tested in vitro by the disc diffusion assay against two Gram-positive and two Gram-negative bacteria, and then the minimum inhibitory concentration using chloramphenicol as reference drug. All the molecules were modeled and optimized by using density functional theory, DFT/B3LYP method. Calculated descriptors, the lower unoccupied molecular orbital and the density were used to interpret the antibacterial activity of the compounds. The results showed that compound 3 is better inhibitor of both types of test bacteria as compared to chloramphenicol.

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Khan, S. A.; Asiri, A. M.; Basheike, A. A.; Sharma, K. Green Synthesis of Novel Pyrazole Containing Schiff Base Derivatives As Antibacterial Agents on the Bases of in-Vitro and DFT. Eur. J. Chem. 2013, 4, 454-458.

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Supporting Agencies

Department of Chemistry and Center of Excellence for Advance Materials at King Abdulaziz University
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