European Journal of Chemistry

Synthesis of some new fluorine substituted thiobarbituric acid derivatives as anti HIV1 and cyclin-dependent kinase 2 (CDK2) for cell tumor division: Part I

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Abdulrahman Salim Al-Harbi
Reda Mohammady Abdel-Rahman
Abdullah Mohamed Asiri


New potential enzyme inhibitors, fluorine-substituted thiobarbituric acid derivatives (2, 3, 9, 8 and 12) and their fused/isolated heterocyclic nitrogen systems (5, 6, 10 and 14) have been obtained from heterocyclization of fluorinated N, Nʹ-disubstituted thiourea (1, 7 and 11) with malonic acid followed by ring closure reactions with primary nitrogen reagents. Structures of the synthesized products have been deduced from their elemental analysis and spectral data. Anti-HIV-1 and inhibition of cyclin-dependent kinase2 (CDK2) for cell tumor division for the synthesized compounds were also evaluated.

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Al-Harbi, A. S.; Abdel-Rahman, R. M.; Asiri, A. M. Synthesis of Some New Fluorine Substituted Thiobarbituric Acid Derivatives As Anti HIV1 and Cyclin-Dependent Kinase 2 (CDK2) for Cell Tumor Division: Part I. Eur. J. Chem. 2015, 6, 63-70.

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