European Journal of Chemistry

Synthesis of new benzisoxazole derivatives and their antimicrobial, antioxidant and anti-inflammatory activities

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Published: Mar 31, 2014
DOI: https://doi.org/10.5155/eurjchem.5.1.91-95.866
Keywords:
Piperidine, Antioxidant, Spirolactone, Benzisoxazole, Antimicrobial, Anti-inflammatory
Section
Research Article
Issue
Vol. 5 No. 1 (2014): March 2014
Dates
Received 2013-07-05
Accepted 2013-09-22
Published 2014-03-31


Main Article Content

Chalya Mallappaji Shivaprasad
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570 006, India
Swamy Jagadish
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570 006, India
Toreshettahally Ramesh Swaroop
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570 006, India
Chakrabhavi Dhananjaya Mohan
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570 006, India
Rangaswamy Roopashree
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570 006, India
Kothanahally Shivaramu Sharath Kumar
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570 006, India
Kanchugarakoppal Subbegowda Rangappa
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570 006, India

Abstract

A series of benzisoxazole derivatives were synthesized and evaluated for their antibacterial, antioxidant and anti-inflammatory activities. The results indicated that most of the compounds exhibit moderate antimicrobial activity against Gram negative (Escherichia coli, Klebsiella pneumoniae, Salmonella typhi, Shigella flexineri) and Gram positive (Bacillus subtilis) bacterial culture. The molecules were evaluated for antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl scavenging, super oxide radical scavenging and hydroxyl radical scavenging assays and most of them showed good antioxidant activities. Also, the synthesized compounds were screened for anti-inflammatory activities such as lipoxygenase inhibition and indirect haemolytic assays.


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Shivaprasad, C. M.; Jagadish, S.; Swaroop, T. R.; Mohan, C. D.; Roopashree, R.; Kumar, K. S. S.; Rangappa, K. S. Synthesis of New Benzisoxazole Derivatives and Their Antimicrobial, Antioxidant and Anti-Inflammatory Activities. Eur. J. Chem. 2014, 5, 91-95.

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References

[1]. Priya, B. S.; Basappa,; Swamy, S. N.; Rangappa, K. S. Bioorg. Med. Chem. 2005, 13, 2623-2628.
http://dx.doi.org/10.1016/j.bmc.2005.01.026

[2]. Stiff, D. D.; Zemaitis, M. A. Drug Metab. Dispos. 1990, 18, 888-894.

[3]. Uno, H.; Kurokawa, M.; Masuda, Y.; Nishimura, H. J. Med. Chem. 1979, 22, 180-188.
http://dx.doi.org/10.1021/jm00188a011

[4]. Gopalsamy, A.; Shi, M.; Golas, J.; Vogan, E.; Jacob, J.; Johnson, M.; Lee, F.; Nilakantan, R.; Petersen, R.; Svenson, K.; Chopra, R.; Tam, M. S.; Wen, Y.; Ellingboe, J.; Arndt, K.; Boschelli, F. J. Med. Chem. 2008, 51, 373-379.
http://dx.doi.org/10.1021/jm701385c

[5]. Jain, M.; Kwon, C. H. J. Med. Chem. 2003, 46, 5428-5434.
http://dx.doi.org/10.1021/jm020581y

[6]. Davis, L.; Effland, R. C.; Klein, J. T.; Dunn, R. W.; Geyer, H. M.; Petko, W. M. Drug Design Disc. 1992, 8, 225-240.

[7]. Strupczewski, J. T.; Allen, R. C.; Gardner, B. A.; Schmid, B. L.; Stache, U.; Glamkowski, E. J.; Jones, M. C.; Ellis, D. B.; Huger, F. P.; Dunn, R. W. J. Med. Chem. 1985, 28, 761-767.
http://dx.doi.org/10.1021/jm00383a012

[8]. Janssen, P. A. J.; Niemegeers, C. J. E.; Awouters, F.; Schellekens, K. H. L.; Megens, A. A. H. P.; Meert, T. F. J. Pharmacol. Exp. Ther. 1988, 244, 685-691.

[9]. Nuhrich, A.; Varache-Lembege, M.; Renard, P.; Devaux, G. Eur. J. Med. Chem. 1994, 29, 75-82.
http://dx.doi.org/10.1016/0223-5234(94)90129-5

[10]. Hasegawa, H. Cur. Med. Res. Opin. 2004, 20, 577-586.
http://dx.doi.org/10.1185/030079904125003313

[11]. Shantharam, C. S.; Suyoga Vardhan, D. M.; Suhas, R.; Sridhara, M. B.; Channe Gowda, D. Eur. J. Med. Chem. 2013, 60, 325-332.
http://dx.doi.org/10.1016/j.ejmech.2012.12.029

[12]. Villalobos, A.; Blake, J. F.; Biggers, C. K.; Butler, T. W.; Chapin, D. S.; Chen, Y. L.; Ives, J. L.; Jones, S. B.; Liston, D. R.; Nagel, A. A.; Nason, D. M.; Nielsen, J. A.; Shalaby, I. A.; White, W. F. J. Med. Chem. 1994, 37, 2721-2730.
http://dx.doi.org/10.1021/jm00043a012

[13]. Rangappa, K. S.; Basappa. J. Phys. Chem. 2005, 18, 773-779.

[14]. Shivaprasad, C. M.; Jagadish, S.; Swaroop, T. R.; Mohan, C. D.; Roopashree, R.; Sharath Kumar, K. S.; Rangappa, K. S. Eur. J. Chem. 2013, 4, 402-407.
http://dx.doi.org/10.5155/eurjchem.4.4.402-407.864

[15]. Chuanga, Y. M. D.; Wanga, Y. S.; Kuob, Y. Y.; Tsaia, H. P.; Shyura, W. L. F. J. Ethnopharmacol. 2004, 95, 409-419.
http://dx.doi.org/10.1016/j.jep.2004.08.010

[16]. Halliwell, B.; Gutteridge, J. M. C.; Arnoma, O. L. Anal. Biochem. 1987, 165, 215-219.
http://dx.doi.org/10.1016/0003-2697(87)90222-3

[17]. Nishimiki, M.; Appaji, N.; Yagi, K. Biochem. Bioph. Res. Co. 1972, 46, 849-854.
http://dx.doi.org/10.1016/S0006-291X(72)80218-3

[18]. Shinde, U. A.; Kulkarni, K. R.; Phadke, A. S.; Nair, A. M.; Mungantiwar, D. V. J.; Saraf, M. N. Indian J. Exp. Biol. 1999, 371, 258-261.

[19]. Boman, H. G.; Kaletta, U Biochim. Biophys. Acta 1957, 24, 619-623.
http://dx.doi.org/10.1016/0006-3002(57)90256-1

[20]. Gaint, S.; Fitton, A. Drugs 1994, 48, 253-273.
http://dx.doi.org/10.2165/00003495-199448020-00009

Supporting Agencies

Board of Research in Nuclear Sciences (BRNS), University Grants Commission (UGC), Indo-French Centre for the Promotion of Advance Research (IFCPAR), Council of Scientific and Industrial Research (CSIR) for Junior and Senior Research Fellowship
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