European Journal of Chemistry 2014, 5(1), 73-80 | doi: https://doi.org/10.5155/eurjchem.5.1.73-80.884 | Get rights and content






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Photostability studies on gemifloxacin and lomefloxacin in bulk powder and dosage forms


Marwa Hosny Tammam (1,*)

(1) Drug Bioavailability Center, National Organization for Drug Control and Research (NODCAR), Giza, 35521, Egypt
(*) Corresponding Author

Received: 24 Jul 2013 | Revised: 18 Aug 2013 | Accepted: 18 Aug 2013 | Published: 31 Mar 2014 | Issue Date: March 2014

Abstract


The photostability of gemifloxacin mesylate (GFLX) and lomefloxacin hydrochloride (LFLX) antibacterial agents in dilute aqueous solutions (bulk powder and dosage form) was studied by applying the International Conference on Harmonization (ICH) recommended conditions. The photodegradation processes were monitored by UV-Vis spectrophotometry and quantified by HPLC. The structures of degradation products in the aqueous solution have been deduced from LC-MS/MS. The GFLX and LFLX photodegradation kinetic rates were also determined. The photodegradation process for GFLX and LFLX solutions can be described as first order kinetic with rate constants 0.105 and 0.119 1/h, respectively, under the applied experimental conditions. The photodegradation rates of GFLX (0.119 1/h) and LFLX (0.0.157 1/h) in aqueous solutions were higher in dosage forms than bulk powder. Titanium dioxide cannot be used as an opacifier with these fluoroquinolone drugs because the rates of photodegradation of GFLX (0.0.161 1/h) and LFLX (0.0.164 1/h) were significantly enhanced by the addition of TiO2. The obtained results showed that these fluoroquinolone drugs are photolabile, thus these two drugs should be strictly protected from light during storage, administration and drug analysis.


Keywords


HPLC; LC-MS/MS; Gemifloxacin; Lomefloxacin; Photostability; Fluoroquinolone drugs

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DOI: 10.5155/eurjchem.5.1.73-80.884

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[1]. Fawzia A. Ibrahim, Medhat A. Al-Ghobashy, Mohamed K. Abd El-Rahman, Ibrahim F. Abo-Elmagd
Optimization and in line potentiometric monitoring of enhanced photocatalytic degradation kinetics of gemifloxacin using TiO2 nanoparticles/H2O2
Environmental Science and Pollution Research  24(30), 23880, 2017
DOI: 10.1007/s11356-017-0045-8
/


[2]. Marwa Hosny Tammam
Erratum to ‘‘Photostability studies on gemifloxacin and lomefloxacin in bulk powder and dosage forms” [Eur. J. Chem. 5 (1) (2014) 73-80]
European Journal of Chemistry  5(4), 695, 2014
DOI: 10.5155/eurjchem.5.4.695-696.1119
/


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How to cite


Tammam, M. Eur. J. Chem. 2014, 5(1), 73-80. doi:10.5155/eurjchem.5.1.73-80.884
Tammam, M. Photostability studies on gemifloxacin and lomefloxacin in bulk powder and dosage forms. Eur. J. Chem. 2014, 5(1), 73-80. doi:10.5155/eurjchem.5.1.73-80.884
Tammam, M. (2014). Photostability studies on gemifloxacin and lomefloxacin in bulk powder and dosage forms. European Journal of Chemistry, 5(1), 73-80. doi:10.5155/eurjchem.5.1.73-80.884
Tammam, Marwa. "Photostability studies on gemifloxacin and lomefloxacin in bulk powder and dosage forms." European Journal of Chemistry [Online], 5.1 (2014): 73-80. Web. 23 Jan. 2020
Tammam, Marwa. "Photostability studies on gemifloxacin and lomefloxacin in bulk powder and dosage forms" European Journal of Chemistry [Online], Volume 5 Number 1 (31 March 2014)

DOI Link: https://doi.org/10.5155/eurjchem.5.1.73-80.884

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