European Journal of Chemistry 2014, 5(1), 33-40 | doi: https://doi.org/10.5155/eurjchem.5.1.33-40.900 | Get rights and content






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Facile synthesis of new fused and non-fused heterocyclic systems from a γ-ketoacid


Marwa Sayed Salem (1,*) , Maher Abd El-Aziz Mahmoud El-Hashash (2) , Al-Shimaa Omar Ali Mahmoud (3) , Hassan Mohamed Fawzy Madkour (4)

(1) Synthetic Organic Chemistry Laboratory, Chemistry Department, Faculty of Science, Ain Shams University, Abbasiya, Cairo, 11566, Egypt
(2) Synthetic Organic Chemistry Laboratory, Chemistry Department, Faculty of Science, Ain Shams University, Abbasiya, Cairo, 11566, Egypt
(3) Synthetic Organic Chemistry Laboratory, Chemistry Department, Faculty of Science, Ain Shams University, Abbasiya, Cairo, 11566, Egypt
(4) Synthetic Organic Chemistry Laboratory, Chemistry Department, Faculty of Science, Ain Shams University, Abbasiya, Cairo, 11566, Egypt
(*) Corresponding Author

Received: 30 Jul 2013 | Revised: 28 Aug 2013 | Accepted: 30 Aug 2013 | Published: 31 Mar 2014 | Issue Date: March 2014

Abstract


The chemical reactivity of 4-(2-tetryl)-4-oxobut-2-enoic acid towards carbon, nitrogen, oxygen, sulfur nucleophiles and binucleophiles namely o-phenylenediamine, o-aminophenol, and o-aminothiophenol has been studied. The investigated nucleophilic reactions result in the formation of heterocyclic compounds with fused and non-fused systems namely, pyridazinone, tetrhydroquinoline, quinoxalone, oxazinone, thiazole and benzocoumarin.


Keywords


Thiazole; Quinoxalone; Pyridazinone; Benzocoumarin; Pyrazolothiazole; Thiazolopyridazine

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DOI: 10.5155/eurjchem.5.1.33-40.900

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Funding information


Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt

Citations

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[1]. Mohamed El-Kady, Eman M. H. Abbas, Marwa S. Salem, Asmaa F. M. Kassem, Sherein I. Abd El-Moez
Synthesis and antimicrobial evaluation of novel 1,3-thiazoles and unsymmetrical azines
Research on Chemical Intermediates  42(4), 3333, 2016
DOI: 10.1007/s11164-015-2214-z
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How to cite


Salem, M.; El-Hashash, M.; Mahmoud, A.; Madkour, H. Eur. J. Chem. 2014, 5(1), 33-40. doi:10.5155/eurjchem.5.1.33-40.900
Salem, M.; El-Hashash, M.; Mahmoud, A.; Madkour, H. Facile synthesis of new fused and non-fused heterocyclic systems from a γ-ketoacid. Eur. J. Chem. 2014, 5(1), 33-40. doi:10.5155/eurjchem.5.1.33-40.900
Salem, M., El-Hashash, M., Mahmoud, A., & Madkour, H. (2014). Facile synthesis of new fused and non-fused heterocyclic systems from a γ-ketoacid. European Journal of Chemistry, 5(1), 33-40. doi:10.5155/eurjchem.5.1.33-40.900
Salem, Marwa, Maher Abd El-Aziz Mahmoud El-Hashash, Al-Shimaa Omar Ali Mahmoud, & Hassan Mohamed Fawzy Madkour. "Facile synthesis of new fused and non-fused heterocyclic systems from a γ-ketoacid." European Journal of Chemistry [Online], 5.1 (2014): 33-40. Web. 19 Jan. 2020
Salem, Marwa, El-Hashash, Maher, Mahmoud, Al-Shimaa, AND Madkour, Hassan. "Facile synthesis of new fused and non-fused heterocyclic systems from a γ-ketoacid" European Journal of Chemistry [Online], Volume 5 Number 1 (31 March 2014)

DOI Link: https://doi.org/10.5155/eurjchem.5.1.33-40.900

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