European Journal of Chemistry

Facile synthesis of new fused and non-fused heterocyclic systems from a γ-ketoacid



Main Article Content

Marwa Sayed Salem
Maher Abd El-Aziz Mahmoud El-Hashash
Al-Shimaa Omar Ali Mahmoud
Hassan Mohamed Fawzy Madkour

Abstract

The chemical reactivity of 4-(2-tetryl)-4-oxobut-2-enoic acid towards carbon, nitrogen, oxygen, sulfur nucleophiles and binucleophiles namely o-phenylenediamine, o-aminophenol, and o-aminothiophenol has been studied. The investigated nucleophilic reactions result in the formation of heterocyclic compounds with fused and non-fused systems namely, pyridazinone, tetrhydroquinoline, quinoxalone, oxazinone, thiazole and benzocoumarin.


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Salem, M. S.; El-Hashash, M. A. E.-A. M.; Mahmoud, A.-S. O. A.; Madkour, H. M. F. Facile Synthesis of New Fused and Non-Fused Heterocyclic Systems from a γ-Ketoacid. Eur. J. Chem. 2014, 5, 33-40.

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Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt
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