European Journal of Chemistry 2014, 5(2), 252-259 | doi: https://doi.org/10.5155/eurjchem.5.2.252-259.990 | Get rights and content

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Characterization and biological activity studies on some transition metal complexes of thiosemicarbazide derived from 2-picolinic acid hydrazide


Eshraga Eltayeb Mohamed (1,*) , Abeer Taha AbedelKarim (2) , Yahia Hassan Elmalik (3) , Amna Elamin Mohamed (4) , Mutlaq Sheeded Aljahdali (5)

(1) Department of Chemistry, Faculty of Pharmacy, Northern Borders University, Rafha, 156, The Kingdom of Saudi Arabia
(2) Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613 , Egypt
(3) Department of Chemistry, Faculty of Pharmacy, Northern Borders University, Rafha, 156, The Kingdom of Saudi Arabia
(4) Department of Chemistry, Faculty of Pharmacy, Northern Borders University, Rafha, 156, The Kingdom of Saudi Arabia
(5) Department of Chemistry, Faculty of Science, King Abd Al-Aziz University, Jeddah, 21589, The Kingdom of Saudi Arabia
(*) Corresponding Author

Received: 05 Dec 2013 | Revised: 02 Jan 2014 | Accepted: 03 Jan 2014 | Published: 30 Jun 2014 | Issue Date: June 2014

Abstract


Mixed-ligand bivalent transition metal ion complexes with N-ethyl-2-picolinoyl hydrazinecarbothioamide (EPHC) and 1,10-phenanthroline (1,10-phen) have been synthesized. The complexes namely [Cu(EPHC)(1,10-phen)(Cl)H2O] (1), [Ni(EPHC)(1,10-phen)(Cl)H2O] (2), [Mn(EPHC)(1,10-phen)(Cl)H2O] (3) and [Co(EPHC)(1,10-phen)(Cl)H2O] (4) were characterized by elemental analysis, spectral (IR, 1H NMR and UV-Vis) and magnetic moment measurements. The magnetic and spectral data indicates octahedral structure for all complexes. Metal complexes have been modeled using parameterized PM3 semi-empirical method. The free ligand and its M(II)-chelates have been screened for their antimicrobial activities. The antibacterial screening demonstrated that, the Cu(II) complex have the maximum and broad activities among the investigated complexes.


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Keywords


Complex; Antifungal; Picolinic acid; Antibacterial; Thiosemicarbazone; Molecular modeling

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DOI: 10.5155/eurjchem.5.2.252-259.990

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Funding information


Northern Borders University, Rafha, The Kingdom of Saudi Arabia

Citations

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[1]. D. Lj. Stojković, V. V. Jevtić, N. Vuković, M. Vukić, I. Potočňák, I. R. Zelen, M. M. Zarić, M. M. Mišić, D. Baskić, G. N. Kaluđerović, S. R. Trifunović
Crystal and molecular structure of a new palladium(II) complex with a coumarin-valine derivate
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[2]. Ashraf A. Aly, Elham M. Abdallah, Salwa A. Ahmed, Mai M. Rabee, Stefan Bräse
Transition Metal Complexes of Thiosemicarbazides, Thiocarbohydrazides, and Their Corresponding Carbazones with Cu(I), Cu(II), Co(II), Ni(II), Pd(II), and Ag(I)—A Review
Molecules  28(4), 1808, 2023
DOI: 10.3390/molecules28041808
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[3]. Neelam P. Prajapati, Hitesh D. Patel
Novel thiosemicarbazone derivatives and their metal complexes: Recent development
Synthetic Communications  , 1, 2019
DOI: 10.1080/00397911.2019.1649432
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How to cite


Mohamed, E.; AbedelKarim, A.; Elmalik, Y.; Mohamed, A.; Aljahdali, M. Eur. J. Chem. 2014, 5(2), 252-259. doi:10.5155/eurjchem.5.2.252-259.990
Mohamed, E.; AbedelKarim, A.; Elmalik, Y.; Mohamed, A.; Aljahdali, M. Characterization and biological activity studies on some transition metal complexes of thiosemicarbazide derived from 2-picolinic acid hydrazide. Eur. J. Chem. 2014, 5(2), 252-259. doi:10.5155/eurjchem.5.2.252-259.990
Mohamed, E., AbedelKarim, A., Elmalik, Y., Mohamed, A., & Aljahdali, M. (2014). Characterization and biological activity studies on some transition metal complexes of thiosemicarbazide derived from 2-picolinic acid hydrazide. European Journal of Chemistry, 5(2), 252-259. doi:10.5155/eurjchem.5.2.252-259.990
Mohamed, Eshraga, Abeer Taha AbedelKarim, Yahia Hassan Elmalik, Amna Elamin Mohamed, & Mutlaq Sheeded Aljahdali. "Characterization and biological activity studies on some transition metal complexes of thiosemicarbazide derived from 2-picolinic acid hydrazide." European Journal of Chemistry [Online], 5.2 (2014): 252-259. Web. 30 May. 2023
Mohamed, Eshraga, AbedelKarim, Abeer, Elmalik, Yahia, Mohamed, Amna, AND Aljahdali, Mutlaq. "Characterization and biological activity studies on some transition metal complexes of thiosemicarbazide derived from 2-picolinic acid hydrazide" European Journal of Chemistry [Online], Volume 5 Number 2 (30 June 2014)

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