European Journal of Chemistry

Characterization and biological activity studies on some transition metal complexes of thiosemicarbazide derived from 2-picolinic acid hydrazide

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Eshraga Eltayeb Mohamed
Abeer Taha AbedelKarim
Yahia Hassan Elmalik
Amna Elamin Mohamed
Mutlaq Sheeded Aljahdali


Mixed-ligand bivalent transition metal ion complexes with N-ethyl-2-picolinoyl hydrazinecarbothioamide (EPHC) and 1,10-phenanthroline (1,10-phen) have been synthesized. The complexes namely [Cu(EPHC)(1,10-phen)(Cl)H2O] (1), [Ni(EPHC)(1,10-phen)(Cl)H2O] (2), [Mn(EPHC)(1,10-phen)(Cl)H2O] (3) and [Co(EPHC)(1,10-phen)(Cl)H2O] (4) were characterized by elemental analysis, spectral (IR, 1H NMR and UV-Vis) and magnetic moment measurements. The magnetic and spectral data indicates octahedral structure for all complexes. Metal complexes have been modeled using parameterized PM3 semi-empirical method. The free ligand and its M(II)-chelates have been screened for their antimicrobial activities. The antibacterial screening demonstrated that, the Cu(II) complex have the maximum and broad activities among the investigated complexes.

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Mohamed, E. E.; AbedelKarim, A. T.; Elmalik, Y. H.; Mohamed, A. E.; Aljahdali, M. S. Characterization and Biological Activity Studies on Some Transition Metal Complexes of Thiosemicarbazide Derived from 2-Picolinic Acid Hydrazide. Eur. J. Chem. 2014, 5, 252-259.

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[1]. Lakshmi, B.; Avaji, P. G.; Shivananda, K. N.; Nagella, P.; Manohar, S. H.; Mahendra, K. N. Polyhedron 2011, 30, 1507-1515.

[2]. Chan, J.; Huang, Y.; Liu, G.; Afrasiabi, Z.; Sinn, E.; Padhye, S.; Ma, Y. Toxicol. Appl. Pharm. 2004, 197, 40-48.

[3]. Rosen, J.; Smith, H.; Wiggall, K. J.; Zhang, L.; Luengo, J. I. J. Med. Chem. 2002, 45, 3573-3575.

[4]. Du, X.; Guo, C.; Hansel, E.; Doyle, P. S.; Caffrey, C. R.; Holler, T. P.; McKerrow, J. H.; Cohen, F. E. J. Med. Chem. 2002, 45, 2695-2707.

[5]. Kovala-Demertzi, D.; Demertzis, M. A.; Filiou, E.; Pantazaki, A. A.; Yadav, P. N.; Miller, J. R.; Zheng, Y.; Kyriakidis, D. A. Biometals 2003, 16, 411-419.

[6]. Scovill, J. P.; Klayman, D. L.; Franchino, D. G. J. Med. Chem. 1982, 25, 1261-1264.

[7]. Klayman, L.; Scovill, J. P.; Bartosevich, J. F.; Bruce, J. J. Med. Chem. 1983, 26, 35-39.

[8]. Demertzi, D. K.; Demertzis, M. A.; Miller, J. R.; Papadopoulou, C.; Dodorou, C.; Filousis, G. J. Inorg. Biochem. 2001, 86, 555-563.

[9]. Shongwe, M. S.; Al-Kharousi, H. N. R.; Adams, H.; Morris, M. J.; Bill, E. Inorg. Chem. 2006, 45, 1103-1107.

[10]. Saha, N. C.; Saha, A.; Butcher, R. J.; Chaudhari, S.; Saha, N. Inorg. Chim. Acta 2002, 339, 348-352.

[11]. Gupta, P.; Basuli, F.; Peng, S. M.; Lee, G. H.; Bhattacharya, S. Inorg. Chem. 2003, 42, 2069-2074.

[12]. Singh, N. K.; Srivastava, A. Trans. Met. Chem. 2000, 25, 133-140.

[13]. Li, J.; Zheng, L. M.; King, I.; Doyle, T. W.; Chen, S. H. Curr. Med. Chem. 2001, 8, 121-133.

[14]. Chandra, S.; Kumar, U.; Verma, H. S. J. Saudi Chem. Soc. 2003, 7(3), 337-346.

[15]. Chandra, S.; Kumar, U.; Verma, H. S. Oriental J. Chem. 2003, 19(2), 355-359.

[16]. Saha, N. C.; Butcher, R. J.; Chaudhuri, S.; Saha, N. Polyhedron 2003, 22, 383-390.

[17]. Chandra, S.; Singh, G.; Tyagi, V. P.; Raizada, S. Synth. React. Inorg. Met. Org. Chem. 2001, 31(10), 1759-1770.

[18]. Malon, M.; Travnicek, Z.; Marysko, M.; Zboril, R.; Maslan, M.; Marek, J.; Dolezal, K.; Rolcik, J.; Krystof, V.; Strnad, M.; Inorg. Chim. Acta 2001, 323, 119-129.

[19]. Saha, D. K.; Padhye, S.; Sinn, E.; Newton, C. Indian J. Chem. A 2002, 41A, 279‐283.

[20]. Booth, B. A.; Moore, E. C.; Sartorelli, A. C. Cancer Res. 1971, 31, 228-234.

[21]. Tojal, J. G.; Orad, A. G.; Serra, J. L.; Pizarro, J. L.; Lezama, L.; Arriortua, M. I.; Rojo, T. J. Inorg. Biochem. 1999, 75, 45-54.

[22]. El-Sherif, A. A.; Aljahdali, M. S. Inorg. Chim. Acta 2013, 407, 58-68.

[23]. Sammes, P. G.; Yahioglu, G. Chem. Soc. Rev. 1994, 23, 327-334.

[24]. Farrell, N. Transition Metal Complexes as Drugs and Chemotherapeutic Agents, Kluwer Academic, Dordrecht, 1989.

[25]. Hyper Chem. version 7. 5 Hypercube, Inc., 2003.

[26]. Bauer, A. W.; Kirby, W. M.; Sherris, C.; Turck, M. Am. J. Clin. Pathol. 1966, 45, 493-496.

[27]. Liebowitz, L. D.; Ashbee, H. R.; Evans, E. G. V.; Chong, Y.; Mallatova, N.; Zaidi, M.; Gibbs, D. Microbiol. Infet. Dis. 2001, 24, 27-33.

[28]. Pfaller, M. A.; Burmeister, L.; Bartlett, M. A.; Rinaldi, M. G. J. Clin. Microbiol. 1988, 26, 1437-1441.

[29]. National Committee for Clinical Laboratory Standards, Reference method for broth dilution antifungal susceptibility testing of conidium-forming filamentous fungi: Proposed standard M38-A, NCCLS, Wayne, PA, USA, 2002.

[30]. Skehan, P.; Storeng, R.; Scudiero, D.; Monks, A.; McMahon, J.; Vistica, D.; Warren, J. T.; Bokesch, H.; Kenney, S.; Boyd, M. R. J. Natl. Cancer Inst. 1990, 82, 1107-1112.

[31]. Aljahdali, M. S. Eur. J. Chem. 2013, 4(4), 434-443.

[32]. Li, Z.; Zhang, Y.; Wang, Y. Phosphor., Sulfur Silicon Relat. Elem. 2003, 178, 293-297.

[33]. Braibanti, A.; Dallavalle, F.; Pellinghelli, M. A.; Leporati, E. Inorg. Chem. 1968, 7, 1430-1433.

[34]. Maurya, R. C.; Mishra, D. D.; Jaiswal, S. K.; Dubey, J. Synth. React. Inorg. Met. Org. Chem. 1995, 25, 521-535.

[35]. John, R. P.; Sreekanth, A.; Rajakannan, V.; Ajith, T. A.; Kurup, M. R. P. Polyhedron 2004, 23, 2549-2559.

[36]. Sreekanth, A.; Joseph, M.; Fun, H. K.; Kurup, M. R. P. Polyhedron 2006, 25, 1408-1411.

[37]. Philip, V.; Suni, V.; Kurup, M. R. P.; Nethaji, M. Polyhedron 2004, 23, 1225-1233.

[38]. Lever, A. B. P. Inorganic Electronic Spectroscopy, 2nd Edition, Elsevier, Amsterdam, 1984.

[39]. El-Sherif, A. A.; Shoukry, M. M.; Abd-Elgawad, M. M. A. Spectrochim. Acta A 2012, 98, 307-321.

[40]. Nakamoto, K. Infrared and Raman Spectra of Inorganic and Coordination Compounds, Wiley-Interscience, New York, 1986.

[41]. Philip, V.; Suni, V.; Kurup, M. R. P. Polyhedron 2006, 25, 1931-1938.

[42]. Sankaraperumal, A.; Karthikeyan, J.; Shetty, A. N.; Lakshmisundaram, R. Polyhedron 2013, 50, 264-269.

[43]. Suzuki, M.; Kanatomi, H.; Koyama, H.; Murase, I. Bull. Chem. Soc. Japan 1980, 53, 1961-1970.

[44]. Li, Q.; Tang, H.; Li, Y.; Wang, M.; Wang, L.; Xia, C. J. Inorg. Biochem. 2000, 78, 167-178.

[45]. Mohan, M.; Kumar, M. Transit. Met. Chem. 1985, 10, 255-258.

[46]. Singh, V. P.; Katiyar, A. J. Pestic. Biochem. Phys. 2008, 92, 8-14.

[47]. El-Sherif, A. A.; Eldebss, T. M. Spectrochim. Acta A 2011, 79, 1803-1814.

[48]. Niswander, R. H.; St Clair A. K.; Edmondson, S. R.; Taylor, L. T. Inorg. Chem. 1975, 14, 478-482.

[49]. Lever, A. B. P.; Lewis, J.; Nyholm, R. S. J. Chem. Soc. 1963, 2552-2556.

[50]. Ballhausen, C. J. An Introduction to Ligand Field; 3rd Edn., McGraw Hill: Newyork, 1962.

[51]. Hathaway, B. J.; Tomlinson, A. A. G. Coord. Chem. Rev. 1970, 5, 143-207.

[52]. Balasubramanian, B.; Krishnan, C. N. Polyhedron 1986, 5, 669-675.

[53]. Dudley, R. J.; Hathaway, B. J. J. Chem. Soc. A 1970, 1725-1728.

[54]. Ferrari, M. B.; Capacchi, S.; Pelosi, G.; Reffo, G.; Tarasconi, P.; Al-bertini, R.; Pinelli, S.; Helicin, P. L. Inorg. Chim. Acta 1999, 286, 134-141.

[55]. Jayabalakrishnan, C.; Natarjan, K. Synth. React. Inorg. Met. Org. Chem. 2001, 31, 983-988.

[56]. Jeeworth, T.; Wah, H. L. K.; Bhowon, M. G.; Ghoorhoo, D.; Babooram, K. Synth. React. Inorg. Met. Org. Chem. 2002, 30, 1023-1038.

[57]. Dharmaraj, N.; Viswanathamurthi, P.; Natarajan, K. Transit. Met. Chem. 2001, 26, 105-112.

[58]. El-Sherif, A. A. Inorg. Chim. Acta 2009, 362, 4991-5000.

[59]. El-Sherif, A. A.; Shoukry, M. M.; Abobakr, L. O. Spectrochim. Acta A 2013, 112, 290-300.

[60]. El-Sherif, A. A. J. Coord. Chem. 2011, 64(12), 2035-2055.

[61]. Pal, I.; Basuli, F.; Bhattacharya, S. Chem. Sci. 2002, 114(4), 255-268.

[62]. Anjaneyula, Y.; Rao, R. P. Synth. React. Inorg. Met. Org. Chem. 1986, 16, 257-272.

[63]. Aljahdali, M. S. Spectrochim. Acta A 2013, 112, 364-376.

[64]. Chohan, Z. H.; Arif, M.; Akhtar, M. A.; Supuran, C. T. Bioinorg. Chem. Appl. 2006, Vol. 2006, Article ID 83131.

[65]. Chohan, Z. H.; Scozzafava, A.; Supuran, C. T. J. Enzym. Inhib. Med. Ch. 2003, 18(3), 259-263.

[66]. Prasad, K. S.; Kumar, L. S.; Shekar, S. C.; Prasad, M.; Revanasiddappa, H. D. J. Chem. Sci. 2011, 12, 1-10.

[67]. Thangadurai, T. D.; Natarajan, K. Transit. Metal Chem. 2001, 26(4-5), 500-504.

[68]. Dharmaraj, N.; Viswanathamurthi, P.; Natarajan, K. Transit. Metal Chem. 2001, 26(1-2), 105-109.

[69]. Joseyphus, R.; Nair, M. Mycobiology 2008, 36, 93-98.

[70]. Malhota, L.; Kumar, S.; Dhindsa, K. S. Indian J. Chem. A 1993, 32, 457-459.

[71]. Koch, A. L. Clin, Microbiol. Rev. 2003, 16, 673-678.

[72]. Collins, R. C.; Davis, R. E. Acta Crystallogr. B 1978, 34, 283-285.

[73]. Sagdinc, S.; Kpksoy, B.; Kandemirli, F.; Bayari, S. H. J. Mol. Struct. 2009, 917, 63-70.

[74]. Dutta, S.; Basuli, F.; Peng, S. M.; Lee, G. H.; Bhattacharya, S. New J. Chem. 2002, 26, 1607-1613.

[75]. Arjunan, P.; Ramamurthy, V.; Ventakesan, K. Acta Crystallogr. C 1984, 40, 556-558.

[76]. Kraker, A.; Krezoski, S.; Schneider, J.; Minkel, D.; Petering, D. H. J. Biol. Chem. 1985, 260, 13710-13718.

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Northern Borders University, Rafha, The Kingdom of Saudi Arabia
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