European Journal of Chemistry 2014, 5(2), 201-208 | doi: https://doi.org/10.5155/eurjchem.5.2.201-208.952 | Get rights and content

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Synthesis of some transition metal complexes of novel 1-methylpyrazole-3-aldehyde-4-(2-pyridyl) thiosemicarbazone: Spectroscopic and in vitro biological activity studies


Mutlaq Shedeed Aljahdali (1,*) , Yahia Hassan Elmalik (2) , Gaber Mohamed Abu El-Reash (3)

(1) Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, The Kingdom of Saudi Arabia
(2) Department of Chemistry, Faculty of Pharmacy, Northern Borders University, Rafhan City 156, The Kingdom of Saudi Arabia
(3) Department of Chemistry, Faculty of Science, Mansoura University, Mansoura City, 002, Egypt
(*) Corresponding Author

Received: 22 Oct 2013 | Revised: 22 Nov 2013 | Accepted: 26 Nov 2013 | Published: 30 Jun 2014 | Issue Date: June 2014

Abstract


Four new mixed ligand metal(II) complexes with 1-methylpyrazole-3-aldehyde-4-(2-pyridyl)thiosemicarbazone (MPAPT) and 1,10-phenanthroline are reported. These complexes namely Cu(MPAPT)(1,10-phen)(Cl)] (1), [Ni(MPAPT)(1,10-phen)(Cl)] (2), [Mn(MPAPT)(1,10-phen)(Cl)].H2O (3) and [Co(MPAPT)(1,10-phen)(Cl)].H2O (4), were characterized by elemental analysis, spectral (IR, 1H NMR and UV-Vis) and magnetic moment measurements. The magnetic and spectral data indicates octahedral structure for all complexes. Metal complexes have been modeled using parameterized PM3 semi-empirical method. The free ligand and its M(II) chelates have been screened for their antimicrobial activities. The antimicrobial screening demonstrated that, the Cu(II) complex have the maximum and broad activities among the investigated complexes.


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Keywords


Spectra; Synthesis; Antifungal activity; Thiosemicarbazone; Molecular modeling; Antibacterial activity

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DOI: 10.5155/eurjchem.5.2.201-208.952

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Supporting information


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How to cite


Aljahdali, M.; Elmalik, Y.; El-Reash, G. Eur. J. Chem. 2014, 5(2), 201-208. doi:10.5155/eurjchem.5.2.201-208.952
Aljahdali, M.; Elmalik, Y.; El-Reash, G. Synthesis of some transition metal complexes of novel 1-methylpyrazole-3-aldehyde-4-(2-pyridyl) thiosemicarbazone: Spectroscopic and in vitro biological activity studies. Eur. J. Chem. 2014, 5(2), 201-208. doi:10.5155/eurjchem.5.2.201-208.952
Aljahdali, M., Elmalik, Y., & El-Reash, G. (2014). Synthesis of some transition metal complexes of novel 1-methylpyrazole-3-aldehyde-4-(2-pyridyl) thiosemicarbazone: Spectroscopic and in vitro biological activity studies. European Journal of Chemistry, 5(2), 201-208. doi:10.5155/eurjchem.5.2.201-208.952
Aljahdali, Mutlaq, Yahia Hassan Elmalik, & Gaber Mohamed Abu El-Reash. "Synthesis of some transition metal complexes of novel 1-methylpyrazole-3-aldehyde-4-(2-pyridyl) thiosemicarbazone: Spectroscopic and in vitro biological activity studies." European Journal of Chemistry [Online], 5.2 (2014): 201-208. Web. 3 Jun. 2023
Aljahdali, Mutlaq, Elmalik, Yahia, AND El-Reash, Gaber. "Synthesis of some transition metal complexes of novel 1-methylpyrazole-3-aldehyde-4-(2-pyridyl) thiosemicarbazone: Spectroscopic and in vitro biological activity studies" European Journal of Chemistry [Online], Volume 5 Number 2 (30 June 2014)

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