European Journal of Chemistry

Synthesis of some transition metal complexes of novel 1-methylpyrazole-3-aldehyde-4-(2-pyridyl) thiosemicarbazone: Spectroscopic and in vitro biological activity studies

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Published: Jun 30, 2014
DOI: https://doi.org/10.5155/eurjchem.5.2.201-208.952
Keywords:
Spectra, Synthesis, Antifungal activity, Thiosemicarbazone, Molecular modeling, Antibacterial activity
Section
Research Article
Issue
Vol. 5 No. 2 (2014): June 2014
Dates
Received 2013-10-22
Accepted 2013-11-26
Published 2014-06-30


Main Article Content

Mutlaq Shedeed Aljahdali
Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, The Kingdom of Saudi Arabia
Yahia Hassan Elmalik
Department of Chemistry, Faculty of Pharmacy, Northern Borders University, Rafhan City 156, The Kingdom of Saudi Arabia
Gaber Mohamed Abu El-Reash
Department of Chemistry, Faculty of Science, Mansoura University, Mansoura City, 002, Egypt

Abstract

Four new mixed ligand metal(II) complexes with 1-methylpyrazole-3-aldehyde-4-(2-pyridyl)thiosemicarbazone (MPAPT) and 1,10-phenanthroline are reported. These complexes namely Cu(MPAPT)(1,10-phen)(Cl)] (1), [Ni(MPAPT)(1,10-phen)(Cl)] (2), [Mn(MPAPT)(1,10-phen)(Cl)].H2O (3) and [Co(MPAPT)(1,10-phen)(Cl)].H2O (4), were characterized by elemental analysis, spectral (IR, 1H NMR and UV-Vis) and magnetic moment measurements. The magnetic and spectral data indicates octahedral structure for all complexes. Metal complexes have been modeled using parameterized PM3 semi-empirical method. The free ligand and its M(II) chelates have been screened for their antimicrobial activities. The antimicrobial screening demonstrated that, the Cu(II) complex have the maximum and broad activities among the investigated complexes.


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Aljahdali, M. S.; Elmalik, Y. H.; El-Reash, G. M. A. Synthesis of Some Transition Metal Complexes of Novel 1-Methylpyrazole-3-Aldehyde-4-(2-Pyridyl) Thiosemicarbazone: Spectroscopic and in Vitro Biological Activity Studies. Eur. J. Chem. 2014, 5, 201-208.

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