European Journal of Chemistry 2013, 4(4), 434-443. doi:10.5155/eurjchem.4.4.434-443.838

Nickel(II) complexes of novel thiosemicarbazone compounds: Synthesis, characterization, molecular modeling and in vitro antimicrobial activity


Mutlaq Shedeed Aljahdali (1,*)

(1) Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, The Kingdom of Saudi Arabia
(*) Corresponding Author

Received: 30 May 2013, Accepted: 03 Jul 2013, Published: 31 Dec 2013

Abstract


A series of novel thiosemicarbazone compounds, HL1, 2-(1-(2-phenyl-hydrazono)-propan-2-ylidene)hydrazine-carbothioamide (TPHP), HL2, N-methyl-2-(1-(2-phenyl-hydrazono)-propan-2-ylidene)hydrazinecarbothioamide (MTPHP) and, HL3, N-phenyl-2-(1-(2-phenyl-hydrazono)-propan-2-ylidene)hydrazinecarbothioamide (PTPHP) and their Ni(II) complexes have been synthesized and characterized using elemental analysis, magnetic susceptibility, molar conductance and spectral measurements. IR spectra indicate that the free ligands exist in the thione form rather than thiol form in the solid state. In all the studied complexes, all ligands behave as a tridenate anion with coordination involving the two azomethine nitrogens and the thiolate sulfur after deprotonation. The magnetic and spectral data indicates a square planar geometry for Ni(II) complexes. The structures of the free thiosemicarbazone ligands and their Ni(II) complexes have been modelled using parameterized PM3 semiempirical method. The free ligands and their Ni(II) chelates have been screened for their antimicrobial activities.

4_4_434_443

Keywords


Spectra; Antifungal; Hydrazine; Antibacterial; Thiosemicarbazone; Molecular modeling

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DOI: 10.5155/eurjchem.4.4.434-443.838

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How to cite


Aljahdali, M. Eur. J. Chem. 2013, 4(4), 434-443. doi:10.5155/eurjchem.4.4.434-443.838
Aljahdali, M. Nickel(II) complexes of novel thiosemicarbazone compounds: Synthesis, characterization, molecular modeling and in vitro antimicrobial activity. Eur. J. Chem. 2013, 4(4), 434-443. doi:10.5155/eurjchem.4.4.434-443.838
Aljahdali, M. (2013). Nickel(II) complexes of novel thiosemicarbazone compounds: Synthesis, characterization, molecular modeling and in vitro antimicrobial activity. European Journal of Chemistry, 4(4), 434-443. doi:10.5155/eurjchem.4.4.434-443.838
Aljahdali, Mutlaq. "Nickel(II) complexes of novel thiosemicarbazone compounds: Synthesis, characterization, molecular modeling and in vitro antimicrobial activity." European Journal of Chemistry [Online], 4.4 (2013): 434-443. Web. 17 Sep. 2019
Aljahdali, Mutlaq. "Nickel(II) complexes of novel thiosemicarbazone compounds: Synthesis, characterization, molecular modeling and in vitro antimicrobial activity" European Journal of Chemistry [Online], Volume 4 Number 4 (31 December 2013)

DOI Link: https://doi.org/10.5155/eurjchem.4.4.434-443.838

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