European Journal of Chemistry 2014, 5(3), 410-414. doi:10.5155/eurjchem.5.3.410-414.996

Anticancer 4: Anticancer and DNA cleavage studies of some new Schiff base titanium (IV) complexes


Ali Gumaan El-Shekeil (1,*) , Abeer Omer Abubakr (2) , Sama Abdalla Al-Aghbari (3) , Mogahid Yahya Nassar (4)

(1) Chemistry Department, Faculty of Science, Sana’a University, Sana’a, 33000, Yemen
(2) Chemistry Department, Faculty of Science, Sana’a University, Sana’a, 33000, Yemen
(3) Chemistry Department, Faculty of Science, Sana’a University, Sana’a, 33000, Yemen
(4) Pathology Department, Faculty of Medicine, University of Science and Technology, Sana’a, 33000, Yemen
(*) Corresponding Author

Received: 07 Dec 2013, Accepted: 27 Feb 2014, Published: 30 Sep 2014

Abstract


Two metal complexes of Ti(IV) were synthesized with newly prepared biologically active ligands. These ligands and their functional groups were carefully designed and selected from well known anticancer drugs. The ligands were prepared by the condensation of a mixture of sulfamethoxazole and the appropriate aldehyde namely, 3,4-dimethoxybenzaldehyde and 3,4,5-trimethoxybenzaldehyde. The structure of the ligands and their complexes were confirmed by spectroscopic data i.e. IR, 1H NMR,electronic and elemental analysis. All compounds were screened for their in vitro anticancer potential using HELA and PC3 cells. All compounds showed limited cytotoxicity and complete cleavage of calf thymus deoxyribonucleic acid (CT-DNA).


Keywords


Titanium; DNA studies; Sulfamethoxazole; Anti-cancer activity; Schiff base complexes; 3,4-Dimethoxybenzaldehyde

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DOI: 10.5155/eurjchem.5.3.410-414.996

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How to cite


El-Shekeil, A.; Abubakr, A.; Al-Aghbari, S.; Nassar, M. Eur. J. Chem. 2014, 5(3), 410-414. doi:10.5155/eurjchem.5.3.410-414.996
El-Shekeil, A.; Abubakr, A.; Al-Aghbari, S.; Nassar, M. Anticancer 4: Anticancer and DNA cleavage studies of some new Schiff base titanium (IV) complexes. Eur. J. Chem. 2014, 5(3), 410-414. doi:10.5155/eurjchem.5.3.410-414.996
El-Shekeil, A., Abubakr, A., Al-Aghbari, S., & Nassar, M. (2014). Anticancer 4: Anticancer and DNA cleavage studies of some new Schiff base titanium (IV) complexes. European Journal of Chemistry, 5(3), 410-414. doi:10.5155/eurjchem.5.3.410-414.996
El-Shekeil, Ali, Abeer Omer Abubakr, Sama Abdalla Al-Aghbari, & Mogahid Yahya Nassar. "Anticancer 4: Anticancer and DNA cleavage studies of some new Schiff base titanium (IV) complexes." European Journal of Chemistry [Online], 5.3 (2014): 410-414. Web. 22 Sep. 2019
El-Shekeil, Ali, Abubakr, Abeer, Al-Aghbari, Sama, AND Nassar, Mogahid. "Anticancer 4: Anticancer and DNA cleavage studies of some new Schiff base titanium (IV) complexes" European Journal of Chemistry [Online], Volume 5 Number 3 (30 September 2014)

DOI Link: https://doi.org/10.5155/eurjchem.5.3.410-414.996

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