European Journal of Chemistry

Anticancer 4: Anticancer and DNA cleavage studies of some new Schiff base titanium (IV) complexes

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Published: Sep 30, 2014
DOI: https://doi.org/10.5155/eurjchem.5.3.410-414.996
Keywords:
Titanium, DNA studies, Sulfamethoxazole, Anti-cancer activity, Schiff base complexes, 3, 4-Dimethoxybenzaldehyde
Section
Research Article
Issue
Vol. 5 No. 3 (2014): September 2014
Dates
Received 2013-12-07
Accepted 2014-02-27
Published 2014-09-30


Main Article Content

Ali Gumaan El-Shekeil
Chemistry Department, Faculty of Science, Sana’a University, Sana’a, 33000, Yemen
Abeer Omer Abubakr
Chemistry Department, Faculty of Science, Sana’a University, Sana’a, 33000, Yemen
Sama Abdalla Al-Aghbari
Chemistry Department, Faculty of Science, Sana’a University, Sana’a, 33000, Yemen
Mogahid Yahya Nassar
Pathology Department, Faculty of Medicine, University of Science and Technology, Sana’a, 33000, Yemen

Abstract

Two metal complexes of Ti(IV) were synthesized with newly prepared biologically active ligands. These ligands and their functional groups were carefully designed and selected from well known anticancer drugs. The ligands were prepared by the condensation of a mixture of sulfamethoxazole and the appropriate aldehyde namely, 3,4-dimethoxybenzaldehyde and 3,4,5-trimethoxybenzaldehyde. The structure of the ligands and their complexes were confirmed by spectroscopic data i.e. IR, 1H NMR,electronic and elemental analysis. All compounds were screened for their in vitro anticancer potential using HELA and PC3 cells. All compounds showed limited cytotoxicity and complete cleavage of calf thymus deoxyribonucleic acid (CT-DNA).


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El-Shekeil, A. G.; Abubakr, A. O.; Al-Aghbari, S. A.; Nassar, M. Y. Anticancer 4: Anticancer and DNA Cleavage Studies of Some New Schiff Base Titanium (IV) Complexes. Eur. J. Chem. 2014, 5, 410-414.

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References

[1]. Naik, A. D.; Annigeri; Gangadharmath, S. M. U. B.; Ravankar, V. K.; Mahale, V. B.; Reddv, V. K. Ind. J. Chem. A 2002, 41(10), 2046-2053.

[2]. Sen, A. K.; Singh G.; Singh, K.; Handa, R. N.; Dubey, S. N.; Squattirito,P. J. Pro. Ind. Acad. Sci. 1998, 110, 75-81.

[3]. Sen, A. K.; Singh, G.; Singh, K.; Noren, R. K.; Handa, R. N.; Dubey, S. N. Ind. J. Chem. 1997, 36A, 891-894.

[4]. Drabent, K.; Bialoska, A.; Ciunik, Z. Inorg. Chem. Commun. 2004, 7(2), 224-227.
http://dx.doi.org/10.1016/j.inoche.2003.11.008

[5]. Klingele, M. H.; Brooker, S.; Coord. Chem. Rev. 2003, 241 (1-2), 119-132.
http://dx.doi.org/10.1016/S0010-8545(03)00049-3

[6]. Arion, V. B.; Reisner, E.; Jokupec, M. A.; Keppler, B. K.; Kukushkin, V. Y.; Pombeiro, A. J. L. Inorg. Chem. 2003, 42(19), 6024-6031.
http://dx.doi.org/10.1021/ic034605i

[7]. Mashaly, M.; Boyoumi, H. A.; Taha, A. Chem. Papers 1999, 53(5), 299-308.

[8]. Kabeer, A. S.; Baseer, M. A.; Mote, N. A. Asian. J. Chem. 2001, 13(2), 496-500.

[9]. El-Masry, A. H.; Fahmy, H. H.; Abdelwahed, S. H. A. Molecules 2000, 5, 1429-1438.
http://dx.doi.org/10.3390/51201429

[10]. More, P. G.; Bhalvankar, R. B.; Patter, S. C. J. Ind. Chem. Soc. 2001, 78(9), 474-475.

[11]. Pandeya, S. N.; Sriram, D.; Nath, G.; Clereq, E. D. Il Farmaco 1999, 54, 624-628.
http://dx.doi.org/10.1016/S0014-827X(99)00075-0

[12]. Singh, W. M.; Dash, B. C. Pesticide. 1988, 22(11), 33-37.

[13]. Desai, S. B.; Desai, P. B.; Desai, K. R. Heterocycl. Commun. 2001, 7(1), 83-90.
http://dx.doi.org/10.1515/HC.2001.7.1.83

[14]. Pathak, P.; Jolly, V. S.; Sharma, K. P. Orient J. Chem. 2000, 16(1), 161-162.

[15]. Samadhiya, S.; Halve, A. Orient J. Chem. 1988 17(1), 33-37.

[16]. Ferrari, M. B.; Capacchi, S.; Pelosi, G.; Reffo, G.; Tarasconi, P.; Albertini, R.; Pinelli, S.; Lunghi; P. Inorg. Chim. Acta. 1999, 286, 134-141.

[17]. Canpolat, E.; Kaya, M. J. Coord. Chem. 2004, 57, 1217-1223.
http://dx.doi.org/10.1080/00958970412331285913

[18]. Yildiz, M.; Dulger, B.; Koyuncu, S. Y.; Yapici, B. M. J. Indian Chem. Soc. 2004, 81, 7-12.

[19]. Wong, E.; Giandomenico, C. M. Chem. Rev. 1999, 99, 2451-2466.
http://dx.doi.org/10.1021/cr980420v

[20]. Clarke, M. J.; Zhu, F.; Frasca, D. R. Chem. Rev. 1999, 99, 2511-2533.
http://dx.doi.org/10.1021/cr9804238

[21]. Kratz, F.; Schutte, M. T. Cancer J. 1998, 11, 176-182.

[22]. Kopf-Maier, P. Eur. J. Clin Pharmacol. 1994, 47, 1-16.
http://dx.doi.org/10.1007/BF00193472

[23]. Kopf-Maier, P.; Kopf, H. Chem. Rev. 1987, 87, 1137-1152.
http://dx.doi.org/10.1021/cr00081a012

[24]. Melendez, E. Crit. Rev. Oncol. Hemat. 2002, 42, 309-315.
http://dx.doi.org/10.1016/S1040-8428(01)00224-4

[25]. Caruso, F.; Rossi, M.; Pettinari, C. Expert. Opin. Ther. Pat. 2001, 11, 969-979.
http://dx.doi.org/10.1517/13543776.11.6.969

[26]. Kopf-Maier, P.; Kopf, H. Struct. Bonding. 1988, 70, 103-185.
http://dx.doi.org/10.1007/3-540-50130-4_3

[27]. Kelter, G.; Sweeney, N. J.; Strohfeldt, K.; Fiebig, H. H.; Take, M. Anticancer Drugs. 2005, 16, 1091-1098.
http://dx.doi.org/10.1097/00001813-200511000-00008

[28]. Christodoulou, C. V.; Elipoulos, A. G.; Young, L. S.; Hodgkins, L.; Ferry, D. R.; Kerr, D. J. British. J. Cancer. 1998, 77, 2088-2097.
http://dx.doi.org/10.1038/bjc.1998.352

[29]. Keppler, B. K.; Friesen, C.; Moritz, H. G.; Vongerichten; Vogel, H. E., Struct. Bonding. 1991, 78, 97-127.
http://dx.doi.org/10.1007/3-540-54261-2_2

[30]. Caruso, F.; Rossi, M.; Tanski, J.; Sartori, R.; Sariego, R.; Moya, S.; Diez, S.; Navarrete, E.; Cingolani, A.; Marchetti, F.; Pettinari, C. J. Med. Chem. 2000, 43, 3665-3670.
http://dx.doi.org/10.1021/jm990539b

[31]. Majumder, A.; Rosair, G. M.; Mallick, A.; Chattopadhyay, N.; Mitra, S. Polyhedron 2006, 25, 1753-1762.
http://dx.doi.org/10.1016/j.poly.2005.11.029

[32]. Singh, K.; Barwa, M. S.; Tyagi, P. Eur. J. Med. Chem. 2006, 41(1), 147-153.
http://dx.doi.org/10.1016/j.ejmech.2005.06.006

[33]. Korfel, A.; Scheulen, M. E.; Schmoll, H. J.; Grundel, O.; Harstrick, A.; Knoche, M.; Fels, M.; Skorzec, M.; Bach, F.; Baumgart, J.; Sab, G.; Seeber, S.; Thiel, E.; Berdel, W. E. Clin. Cancer Res. 1998, 4, 2701-2708.

[34]. Lummen, G.; Sperling, H.; Luboldt, H.; Otto, T.; Rubben, H. Cancer Chemother. Pharmacol. 1998, 42, 415-417.
http://dx.doi.org/10.1007/s002800050838

[35]. El-Shekeil, A.; Obeid, A. O.; Al-Aghbari, S. Eur. J. Chem. 2012, 3(3), 356-358.
http://dx.doi.org/10.5155/eurjchem.3.3.356-358.621

[36]. Irob, O. N.; Moo-Young, M.; Anderson, W. A. Intl. J. Pharmacogn. 1996, 34, 87-90.
http://dx.doi.org/10.1076/phbi.34.2.87.13201

[37]. Mosmann, T. J. Iimmunol. Methods 1983, 65, 55-63.

[38]. Silverstien, M.; Bassler, G.; Morril, C., Spectrometric Identification of Organic Compounds, 4th edn., p. 133, John Wiley & Sons, New York, 1981.

[39]. Katritzky, A. R.; Pozharskii, A. F. Handbook of Heterocyclic Chemistry, 2nd edn, p. 117, Pergamon, UK, 2000.

[40]. Prasad, K. S; Kumar, L. S; Parasad, M.; Revanasiddappa, H. D. Bioinorg. Chem. Appl. 2010, Article ID: 854514, 1.

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