European Journal of Chemistry 2016, 7(3), 280-282 | doi: https://doi.org/10.5155/eurjchem.7.3.280-282.1431 | Get rights and content






  OPEN ACCESS | PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS

Synthesis, characterization and acute toxicity of new Schiff base derived from L-arginine and vanillin


Wasfi Aboud Al-Masoudi (1,*) , Mohammed Ali Al-Diwan (2) , Orass Saad Khayoon (3)

(1) Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, University of Basrah, Basrah, 61001, Iraq
(2) Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, University of Basrah, Basrah, 61001, Iraq
(3) Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, University of Basrah, Basrah, 61001, Iraq
(*) Corresponding Author

Received: 25 Mar 2016 | Revised: 26 Apr 2016 | Accepted: 29 Apr 2016 | Published: 30 Sep 2016 | Issue Date: September 2016

Abstract


Condensation of L-arginine with 4-hydroxy-3-methoxy benzaldehyde (vanillin) yielded a novel Schiff base derivative of arginine in good yield. This new Schiff base was characterized by elemental analysis, IR and 1H NMR spectroscopy. The toxicity of the compound was also assayed via the determination of their LD50 value by using Dixon method. Studied compound was found to have an LD50 of 718.6 mg/kg of body weight.


Keywords


Vanillin; Schiff base; L-Arginine; Amino acid; Acute toxicity; Median lethal dose

Full Text:

PDF /    /


DOI: 10.5155/eurjchem.7.3.280-282.1431

Links for Article


| | | | | | |

| | | | | | |

| |

Related Articles




Article Metrics

This Abstract was viewed 812 times | PDF Article downloaded 348 times

Funding information


Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, Al-Basrah University, Iraq

References

[1]. Tapiero, H.; Mathe, G.; Couvreur, P.; Tew, K. D. Biomed. Pharmacother. 2002, 56(9), 439-445.
http://dx.doi.org/10.1016/S0753-3322(02)00284-6

[2]. Stechmiller, J. K.; Childress, B.; Cowan, L. Nutr. Clin. Prac. 2005, 20(1), 52-61.
http://dx.doi.org/10.1177/011542650502000152

[3]. Witte, M. B.; Barbul, A. Wound Repair Regen. 2003, 11(6), 419-423.
http://dx.doi.org/10.1046/j.1524-475X.2003.11605.x

[4]. Wascher, T. C.; Graier, W. F.; Dittrich, P.; Hussain, M. A.; Bahadori, B.; Wallner, S.; Toplak, H. Eur. J. Clin. Invest. 1997, 27(8), 690-695.
http://dx.doi.org/10.1046/j.1365-2362.1997.1730718.x

[5]. Lubec, B.; Hayn, M.; Kitzmuller, E.; Vierhapper, H.; Lubec, G. Free Radic. Biol. Med. 1997, 22(1-2), 355-357.
http://dx.doi.org/10.1016/S0891-5849(96)00386-3

[6]. Campbell, B. I.; La-Bounty, P. M.; Roberts, M. J. Int. Soc. Sports. Nutr. 2004, 1(2), 35-38.
http://dx.doi.org/10.1186/1550-2783-1-2-35

[7]. Collier, S. R.; Casey, D. P.; Kanaley, J. A. Growth Horm. IGF. Res. 2005, 15(2), 136-139.
http://dx.doi.org/10.1016/j.ghir.2004.12.004

[8]. Boger, R. H.; Bode-Boger, S. M.; Mugge, A.; Kienke, S.; Brandes, R.; Dwenger, A.; Frölich, J. C. Atherosclerosis 1995, 117(2), 273-284.
http://dx.doi.org/10.1016/0021-9150(95)05582-H

[9]. Grasemann, H.; Kurtz, F.; Ratjen, F. Am. J. Respir. Crit. Care Med. 2006, 174(2), 208-212.
http://dx.doi.org/10.1164/rccm.200509-1439OC

[10]. Angeli, G.; Turibio, L.; Daniel, F.; Marcelo, L. Rev. Bras. Med. Esporte. 2007, 13(2), 112-115.
http://dx.doi.org/10.1590/S1517-86922007000200012

[11]. Sari, N.; Gurkan, P. Z. Naturforsch. B 2004, 59, 692-698.

[12]. Walton, N. J.; Mayer, M. J.; Narbad, A. Phytochemistry 2003, 63, 505-515.
http://dx.doi.org/10.1016/S0031-9422(03)00149-3

[13]. Burrite, J.; Graf, M.; Lambelet, P.; Loliger, J. J. Sci. Food Agric. 1989, 48, 49-56.
http://dx.doi.org/10.1002/jsfa.2740480107

[14]. Kamat, J. P.; Ghosh, A.; Devasagayam, T. P. A. Mol. Cell. Biochem. 2000, 209, 47-53.
http://dx.doi.org/10.1023/A:1007048313556

[15]. Dixon, W. J. Ann. Res. Pharmacol. Toxicol. 1980, 20, 441-462.
http://dx.doi.org/10.1146/annurev.pa.20.040180.002301

How to cite


Al-Masoudi, W.; Al-Diwan, M.; Khayoon, O. Eur. J. Chem. 2016, 7(3), 280-282. doi:10.5155/eurjchem.7.3.280-282.1431
Al-Masoudi, W.; Al-Diwan, M.; Khayoon, O. Synthesis, characterization and acute toxicity of new Schiff base derived from L-arginine and vanillin. Eur. J. Chem. 2016, 7(3), 280-282. doi:10.5155/eurjchem.7.3.280-282.1431
Al-Masoudi, W., Al-Diwan, M., & Khayoon, O. (2016). Synthesis, characterization and acute toxicity of new Schiff base derived from L-arginine and vanillin. European Journal of Chemistry, 7(3), 280-282. doi:10.5155/eurjchem.7.3.280-282.1431
Al-Masoudi, Wasfi, Mohammed Ali Al-Diwan, & Orass Saad Khayoon. "Synthesis, characterization and acute toxicity of new Schiff base derived from L-arginine and vanillin." European Journal of Chemistry [Online], 7.3 (2016): 280-282. Web. 25 Nov. 2020
Al-Masoudi, Wasfi, Al-Diwan, Mohammed, AND Khayoon, Orass. "Synthesis, characterization and acute toxicity of new Schiff base derived from L-arginine and vanillin" European Journal of Chemistry [Online], Volume 7 Number 3 (30 September 2016)

The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item


DOI Link: https://doi.org/10.5155/eurjchem.7.3.280-282.1431

| | | | | | | |

| | | | | |

Save to Zotero Save to Mendeley



European Journal of Chemistry 2016, 7(3), 280-282 | doi: https://doi.org/10.5155/eurjchem.7.3.280-282.1431 | Get rights and content

Refbacks

  • There are currently no refbacks.




Copyright (c)




© Copyright 2010 - 2020  Atlanta Publishing House LLC All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2010-2020 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.