

Synthesis, antimicrobial activity and modelling studies of some new metal complexes of Schiff base derived from sulphonamide drug in vitro
Wasfi Aboud Al-Masoudi (1)




(1) Department of Physiology and Chemistry, College of Veterinary, University of Basrah, Basrah 61001, Iraq
(2) Department of Microbiology, College of Veterinary, University of Basrah, Basrah 61001, Iraq
(3) Department of Chemistry, College of Education for Pure Sciences, University of Basrah, Basrah 61001, Iraq
(4) Department of Basic Sciences, College of Dentistry, University of Basrah, Basrah 61001, Iraq
(*) Corresponding Author
Received: 26 Nov 2015 | Accepted: 02 Jan 2016 | Published: 31 Mar 2016 | Issue Date: March 2016
Abstract
Palladium(II) and cobalt(II) complexes of Schiff base derived from 4-aminobenzene sulfonamide (Sulfonamide drug) were prepared by convenient method. Reaction of sulfonamide with 2-hydroxy-1-naphthaldehyde gave the Schiff base compound 1 in good yield. Treatment of compound 1 with CoCl2.6H2O and PdCl2yielded new metal complexes 2 and 3, respectively. The synthesized compounds were screened for their antibacterial activity against Escherichia coli, Bacillus cereus, Salmonella spp. and Staphylococcus aureus. Additionally, the compounds were tested for antifungal activity against Aspergillus niger and Candida albicans. Some compounds exhibited good antibacterial and antifungal activity. Molecular modeling studies were performed and showed hydrogen binding and hydrophobic interactions.
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.7.1.102-106.1374
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Departments of Physiology and Microbiology, College of Veterinary Medicine, Basrah University, Iraq
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