European Journal of Chemistry

Synthesis, antimicrobial activity and modelling studies of some new metal complexes of Schiff base derived from sulphonamide drug in vitro

Article Sidebar

PDF
Published: Mar 31, 2016
DOI: https://doi.org/10.5155/eurjchem.7.1.102-106.1374
Keywords:
Synthesis, Schiff base, Sulfonamide, Metal complexes, Modeling studies, Antimicrobial activity
Section
Research Article
Issue
Vol. 7 No. 1 (2016): March 2016
Dates
Received 2015-11-26
Accepted 2016-01-02
Published 2016-03-31


Main Article Content

Wasfi Aboud Al-Masoudi
Department of Physiology and Chemistry, College of Veterinary, University of Basrah, Basrah 61001, Iraq
Rana Adnan Faaz
Department of Microbiology, College of Veterinary, University of Basrah, Basrah 61001, Iraq
Rafid Hmedan Al-Asadi
Department of Chemistry, College of Education for Pure Sciences, University of Basrah, Basrah 61001, Iraq
Hazim Saad Jabbar
Department of Basic Sciences, College of Dentistry, University of Basrah, Basrah 61001, Iraq

Abstract

Palladium(II) and cobalt(II) complexes of Schiff base derived from 4-aminobenzene sulfonamide (Sulfonamide drug) were prepared by convenient method. Reaction of sulfonamide with 2-hydroxy-1-naphthaldehyde gave the Schiff base compound 1 in good yield. Treatment of compound 1 with CoCl2.6H2O and PdCl2yielded new metal complexes 2 and 3, respectively. The synthesized compounds were screened for their antibacterial activity against Escherichia coli, Bacillus cereus, Salmonella spp. and Staphylococcus aureus. Additionally, the compounds were tested for antifungal activity against Aspergillus niger and Candida albicans. Some compounds exhibited good antibacterial and antifungal activity. Molecular modeling studies were performed and showed hydrogen binding and hydrophobic interactions.


icon graph This Abstract was viewed 2187 times | icon graph Article PDF downloaded 953 times

How to Cite
(1)
Al-Masoudi, W. A.; Faaz, R. A.; Al-Asadi, R. H.; Jabbar, H. S. Synthesis, Antimicrobial Activity and Modelling Studies of Some New Metal Complexes of Schiff Base Derived from Sulphonamide Drug in Vitro. Eur. J. Chem. 2016, 7, 102-106.

Article Details

Share
Links for Article


Crossref - Scopus - Google - European PMC
Crossref
Scopus
Google Scholar
Europe PMC
References

[1]. Robin, R. C.; Melissa, K. R.; Johanna, M. B.; Joshwa, C. S.; Scott, N. Trans. Metal Chem. 2005, 30, 411-418.
http://dx.doi.org/10.1007/s11243-004-7625-4

[2]. Shivakumar, K.; Shashidhar; Reddy, P. V.; Halli, M. B. J. Coord. Chem. 2008, 61(14), 2274-2287.
http://dx.doi.org/10.1080/00958970801905239

[3]. Shi, L.; Mao, W. J.; Yang, Y.; Zhu, H. L. J. Coord. Chem. 2009, 62(21), 3471-3477.
http://dx.doi.org/10.1080/00958970903093694

[4]. Gupta, M. K.; Har, L. S.; Varshney, S.; Vareshny, A. K. Bioinorg. Chem. Appl. 2003, 1(3-4), 309-320.
http://dx.doi.org/10.1155/S1565363303000244

[5]. Hahn, R. C.; Moratoconciecao, Y. T.; Santos, N. L.; Ferreira, J. F.; Hamdan, J. S. Mycoses 2003, 46, 342-347.
http://dx.doi.org/10.1046/j.1439-0507.2003.00901.x

[6]. Henry, R. J. Bacteriol. Rev. 1943, 7(4), 175-262.

[7]. Mohamed, G. G.; Carmen, M. S. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2007, 66, 949-958.
http://dx.doi.org/10.1016/j.saa.2006.04.033

[8]. Rudzinski, W. E.; Aminabhavie, T. M.; Biradar, N. S.; Patil, C. S. Inorg. Chim. Acta. 1982, 67, 177-182.
http://dx.doi.org/10.1016/S0020-1693(00)85061-6

[9]. Raveendran, R.; Pal, S. J. Organomet. Chem. 2007, 692(4), 824-830.
http://dx.doi.org/10.1016/j.jorganchem.2006.10.026

[10]. Orvig, C.; Abrams, M. J. Chem. Rev. 1999, 99, 2201-2203
http://dx.doi.org/10.1021/cr980419w

[11]. Saha, N.; Muherjee, D. Inorg. Chem. Acta 1987, 137, 161-166.
http://dx.doi.org/10.1016/S0020-1693(00)81160-3

[12]. Shah, S. N; Basser, M. A. Asian J. Pharm. Clin. Res. 2012, 5(3), 146-149.

[13]. Zhan, P.; Liu, X.; Li, Z.; Fang, Z.; Pannecouque, C.; De Clercq, E. Chem. Biodivers. 2010, 7, 1717-1727.
http://dx.doi.org/10.1002/cbdv.200900197

[14]. Onuffer, J. J.; Ton, B. T.; Kleent, I.; Kirsch, J. F. Protein Sci. 1995, 4, 1743-1749.
http://dx.doi.org/10.1002/pro.5560040909

[15]. Seeliger, S.; de Groot, B. L. J. Computer-Aided Mol. Design 2010, 24, 417-422.

[16]. Al-Masoudi, W. A.; Mohmmed, A. L.; Abass, W. H.; Al-Masoudi, N. A. Eur. J. Chem. 2015, 6(2), 127-130.
http://dx.doi.org/10.5155/eurjchem.6.2.127-130.1175

Supporting Agencies

Departments of Physiology and Microbiology, College of Veterinary Medicine, Basrah University, Iraq
Most read articles by the same author(s)
TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2025 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).